CONTROL OF ELECTRON FLUX THROUGH THE RESPIRATORY CHAIN IN MITOCHONDRIA AND CELLS

Coupling of Phosphorylation to Electron and Hydrogen Transfer by a Chemi-Osmotic type of Mechanism

1961 • 4,416 citations

CHEMIOSMOTIC COUPLING IN OXIDATIVE AND PHOTOSYNTHETIC PHOSPHORYLATION

1966 • 3,631 citations

The Respiratory Chain and Oxidative Phosphorylation

1956 • 2,073 citations

Nonequilibrium Thermodynamics in Biophysics

1965 • 1,704 citations

THE MITOCHONDRIAL ELECTRON TRANSPORT AND OXIDATIVE PHOSPHORYLATION SYSTEM

1985 • 1,599 citations

Thermogenic mechanisms in brown fat.

1984 • 1,593 citations

RESPIRATORY ENZYMES IN OXIDATIVE PHOSPHORYLATION

1955 • 1,457 citations

Regulation of Hepatic Fatty Acid Oxidation and Ketone Body Production

1980 • 1,430 citations

A Linear Steady-State Treatment of Enzymatic Chains. General Properties, Control and Effector Strength

1974 • 1,378 citations

OXIDATIVE PHOSPHORYLATIONS: RÔLE OF INORGANIC PHOSPHATE AND ACCEPTOR SYSTEMS IN CONTROL OF METABOLIC RATES

1952 • 744 citations

Gluconeogenesis in the perfused rat liver

1966 • 726 citations

The Influence of Respiration and ATP Hydrolysis on the Proton‐Electrochemical Gradient across the Inner Membrane of Rat‐Liver Mitochondria as Determined by Ion Distribution

1974 • 707 citations

Influence of Thyroid Hormones on l-α-Glycerophosphate Dehydrogenases and Other Dehydrogenases in Various Organs of the Rat

1965 • 638 citations

Metabolite Transport in Mitochondria

1979 • 618 citations

Quantification of the contribution of various steps to the control of mitochondrial respiration.

1982 • 617 citations

Estimation of Membrane Potential and pH Difference across the Cristae Membrane of Rat Liver Mitochondria

1969 • 589 citations

Mitochondria: a historical review.

1981 • 562 citations

Stimulation by calcium ions of pyruvate dehydrogenase phosphate phosphatase

1972 • 519 citations

Mitochondrial calcium transport

1982 • 486 citations

Membranes and ion transport

1970 • 484 citations

Effect of surface active agents on the latent ATPASE of mitochondira

1956 • 455 citations

Molecular Democracy: Who Shares the Controls?

1979 • 454 citations

Hormonal effects on calcium homeostasis in isolated hepatocytes.

1980 • 441 citations

Regulation of cellular energy metabolism

1982 • 433 citations

The effects of calcium ions and adenine nucleotides on the activity of pig heart 2-oxoglutarate dehydrogenase complex

1979 • 431 citations

Adenine Nucleotide Translocation of Mitochondria

1968 • 417 citations

On the role of the calcium transport cycle in heart and other mammalian mitochondria

1980 • 375 citations

Changes in free cytosolic Ca2+ in hepatocytes following alpha 1-adrenergic stimulation. Studies on Quin-2-loaded hepatocytes.

1983 • 375 citations

Molecular and physiological aspects of adenine nucleotide trasport in mitochondria

1976 • 373 citations

Brown adipose tissue mitochondria

1979 • 369 citations

Relation between mitochondrial calcium transport and control of energy metabolism

1985 • 362 citations

The oxygen dependence of cellular energy metabolism

1979 • 360 citations

Calcium ions and the regulation of NAD+-linked isocitrate dehydrogenase from the mitochondria of rat heart and other tissues

1978 • 359 citations

Relationship between inositol polyphosphate production and the increase of cytosolic free Ca2+ induced by vasopressin in isolated hepatocytes.

1984 • 358 citations

Reversible Inhibition of Mitochondrial Adenosine Diphosphate Phosphorylation by Long Chain Acyl Coenzyme A Esters

1971 • 357 citations

Metabolic Effects of Ethanol in Perfused Rat Liver

1969 • 327 citations

Role of calcium in the hormonal regulation of liver metabolism

1981 • 317 citations

Regulation of Hepatic Metabolism

1976 • 314 citations

Uncoupling activity of long-chian fatty acids

1962 • 310 citations

Role of calcium ions in the regulation of intramitochondrial metabolism. Effects of Na+, Mg2+ and ruthenium red on the Ca2+-stimulated oxidation of oxoglutarate and on pyruvate dehydrogenase activity in intact rat heart mitochondria

1980 • 292 citations

MITOCHONDRIA AND THE CONTROL OF INTRACELLULAR CALCIUM

1978 • 278 citations

Cellular Thermogenesis

1976 • 274 citations

Hormonal regulation of hepatic gluconeogenesis.

1984 • 272 citations

The role of malonyl-coa in the coordination of fatty acid synthesis and oxidation in isolated rat hepatocytes.

1978 • 269 citations

Determination of the mitochondrial protonmotive force in isolated hepatocytes.

1980 • 263 citations

Vectorial reactions in electron and ion transport in mitochondria and bacteria

1981 • 249 citations

Electron transfer Chains and oxidative phosphorylation

1976 • 248 citations

Ca2+ transport by mammalian mitochondria and its role in hormone action

1985 • 242 citations

Effect of glucagon on metabolite compartmentation in isolated rat liver cells during gluconeogenesis from lactate

1977 • 234 citations

Control Mechanisms of Gluconeogenesis and Ketogenesis

1969 • 230 citations

Respiratory Control and the Proton Electrochemical Gradient in Mitochondria

1973 • 228 citations

The metabolic significance of anion transport in mitochondria

1974 • 225 citations

THE RELATIONSHIP BETWEEN THE STRUCTURE AND ACTIVITY OF RAT SKELETAL MUSCLE MITOCHONDRIA AFTER THYROIDECTOMY AND THYROID HORMONE TREATMENT

1965 • 214 citations

Control of mitochondrial respiration

1983 • 210 citations

Thyroid Hormone Action at the Cell Level

1979 • 206 citations

A minimal hypothesis for membrane-linked free-energy transduction

1984 • 204 citations

Cytochrome oxidase: A synthesis

1982 • 201 citations

Studies on alpha-adrenergic activation of hepatic glucose output. The role of mitochondrial calcium release in alpha-adrenergic activation of phosphorylase in perfused rat liver.

1979 • 201 citations

Metabolic compartmentation

1983 • 199 citations

The interactions of coupling ATPases with nucleotides

1978 • 187 citations

Norepinephrine, vasopressin, glucagon, and A23187 induce efflux of calcium from an exchangeable pool in isolated rat hepatocytes

1978 • 186 citations

The inhibition of adenine nucleotide translocase activity by oleoyl CoA and its reversal in rat liver mitochondria

1971 • 185 citations

Subcellular Metabolite Concentrations

1978 • 182 citations

Modern theories of metabolic control and their applications

1984 • 179 citations

Energy-linked nicotinamide nucleotide transhydrogenases

1977 • 176 citations

Fully delocalised chemiosmotic or localised proton flow pathways in energy coupling?

1985 • 173 citations

Factors controlling the rate of fatty acid β-oxidation in rat liver mitochondria

1972 • 171 citations

Regulation of the citric acid cycle in mammalian systems

1980 • 171 citations

Regulation of respiration and ATP synthesis in higher organisms: Hypothesis

1986 • 170 citations

Thyroid Hormone Action: The Mitochondrial Pathway

1977 • 170 citations

Non-ohmic proton conductance of mitochondria and liposomes

1984 • 170 citations

Quantitative dependence of mitochondrial oxidative phosphorylation on oxygen concentration: A mathematical model

1979 • 168 citations

Metabolic control analysis of moiety‐conserved cycles

1986 • 165 citations

THE STIMULATION BY TREATMENT IN VIVO WITH TRI-IODOTHYRONINE OF AMINO ACID INCORPORATION INTO PROTEIN BY ISOLATED RAT-LIVER MITOCHONDRIA

1965 • 165 citations

Hepatic Sulfite Oxidase

1972 • 163 citations

Proton Electrochemical Gradients and Energy-Transduction Processes

1982 • 163 citations

Non-equilibrium thermodynamics of energy conversion in bioenergetics

1979 • 162 citations

Effect of long-chain fatty acids and acyl-CoA on mitochondrial permeability, transport, and energy-coupling processes

1976 • 162 citations

The Regulation of Metabolism

1973 • 161 citations

Involvement of intramitochondrial protons in redox reactions of cytochrome a

1978 • 158 citations

Role of calcium ions in the regulation of intramitochondrial metabolism. Properties of the Ca2+-sensitive dehydrogenases within intact uncoupled mitochondria from the white and brown adipose tissue of the rat

1980 • 157 citations

The Biogenesis of Mitochondria in Microorganisms

1972 • 157 citations

Role of Ca2+ ions in the regulation of intramitochondrial metabolism in rat heart. Evidence from studies with isolated mitochondria that adrenaline activates the pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase complexes by increasing the intramitochondrial concentration of Ca2+

1984 • 151 citations

Control of Mitochondrial Substrate Oxidation

1980 • 151 citations

Control of mitochondrial respiration: A quantitative evaluation of the roles of cytochrome c and oxygen

1977 • 150 citations

Mitochondrial functions under hypoxic conditions: The steady states of cytochrome c reduction and of energy metabolism

1974 • 149 citations

Effect of nicotinamide adenine dinucleotide on the membrane-associated reduced nicotinamide adenine dinucleotide oxidase of Mycobacterium phlei.

1975 • 145 citations

Mitochondrial function under hypoxic conditions: The steady states of cytochrome a+a3 and their relation to mitochondrial energy states

1974 • 145 citations

Calcium ion fluxes induced by the action of α-adrenergic agonists in perfused rat liver

1982 • 144 citations

Determination of the matrix free Ca2+ concentration and kinetics of Ca2+ efflux in liver and heart mitochondria.

1982 • 144 citations

Inhibition of Glucagon Effects in Perfused Rat Liver by (+)Decanoylcarnitine

1969 • 140 citations

Glucagon stimulation of mitochondrial respiration.

1975 • 139 citations

Oxygen pressure gradients in isolated cardiac myocytes.

1985 • 139 citations

Characterization of the effects of Ca2+ on the intramitochondrial Ca2+-sensitive enzymes from rat liver and within intact rat liver mitochondria

1985 • 139 citations

Regulation of cellular metabolism by intracellular phosphate

1977 • 134 citations

Phosphorylation state of cytosolic and mitochondrial adenine nucleotides and of pyruvate dehydrogenase in isolated rat liver cells

1976 • 133 citations

The Effective Proton Conductance of the Inner Membrane of Mitochondria from Brown Adipose Tissue

1977 • 133 citations

Molecular slipping in redox and ATPase H+ pumps

1983 • 131 citations

Evidence for mitochondrial localization of the hormone-responsive pool of Ca2+ in isolated hepatocytes.

1979 • 128 citations

Energy relationships between cytosolic metabolism and mitochondrial respiration in rat heart

1978 • 127 citations

Physiological and bioenergetic aspects of mitochondrial calcium transport

1983 • 122 citations

Mitochondrial Thyroid Hormone Receptor: Localization and Physiological Significance

1978 • 121 citations

Ruthenium Red inhibits the activation of pyruvate dehydrogenase caused by positive inotropic agents in the perfused rat heart

1983 • 119 citations

Stimulation of pyruvate transport in metabolizing mitochondria through changes in the transmembrane pH gradient induced by glucagon treatment of rats

1978 • 118 citations

Evaluation of oxidative phosphorylation in hearts from euthyroid, hypothyroid, and hyperthyroid rats

1978 • 117 citations

Rapid Effect of Triiodothyronine on the Mitochondrial Pathway in Rat Liver in Vivo

1980 • 117 citations

Biochemical and Ultrastructural Evaluation of Isolated Rat Liver Systems Perfused with a Hemoglobin-Free Medium

1978 • 117 citations

Biomedical and clinical aspects of coenzyme Q

1987 • 116 citations

Intrinsic uncoupling of mitochondrial proton pumps. 1. Nonohmic conductance cannot account for the nonlinear dependence of static head respiration on .DELTA.~.mu.H

1986 • 114 citations

The Thermodynamic Description of Enzyme-Catalyzed Reactions

1973 • 114 citations

Mitochondrial Function in the Heart

1979 • 114 citations

Cytosolic free Ca²⁺ in isolated rat hepatocytes as measured by quin2

1984 • 111 citations

Biochemical and stereological analysis of rat liver mitochondria in different thyroid states

1978 • 111 citations

Homeostatic regulation of cellular energy metabolism: experimental characterization in vivo and fit to a model

1978 • 110 citations

Thermodynamic control of electron flux through mitochondrial cytochrome bc1 complex

1985 • 109 citations

Mitochondrial and cytosolic ATP/ADP ratios in rat liver in vivo

1981 • 109 citations

CONTROL OF MITOCHONDRIAL TURNOVER UNDER THE INFLUENCE OF THYROID HORMONE

1971 • 106 citations

Changes in permeability to protons and other cations at high proton motive force in rat liver mitochondria

1986 • 106 citations

Electron flux through the mitochondrial ubiquinone

1980 • 103 citations

Proton electrochemical gradient and rate of controlled respiration in mitochondria

1978 • 102 citations

Phosphate dependence and atractyloside inhibition of mitochondrial oxidative phosphorylation. The ADP-ATP carrier is rate-limiting.

1979 • 101 citations

Control of the rate of reverse electron transport in submitochondrial particles by the free energy

1977 • 101 citations

Control of mitochondrial respiration. The contribution of the adenine nucleotide translocator depends on the ATP- and ADP-consuming enzymes

1983 • 100 citations

The effects of ammonium chloride and glucagon on the metabolism of glutamine in isolated liver cells from starved rats

1978 • 99 citations

Measurement of steady-state values of respiration rate and oxidation levels of respiratory pigments at low oxygen tensions. A new technique

1971 • 99 citations

The origin, quantitation, and kinetics of intracellular calcium mobilization by vasopressin and phenylephrine in hepatocytes.

1983 • 97 citations

Regulation of oxidative phosphorylation in mitochondria by external free Ca2+ concentrations.

1985 • 94 citations

Proton electrochemical gradient and phosphate potential in mitochondria

1978 • 94 citations

The stimulatory effect of glucagon and dibutyryl cyclic AMP on ureogenesis and gluconeogenesis in relation to the mitochondrial ATP contnet

1977 • 94 citations

Stable changes to calcium fluxes in mitochondria isolated from rat livers perfused with α-adrenergic agonists and with glucagon

1980 • 93 citations

Factors determining the relative contribution of the adenine‐nucleotide translocator and the ADP‐regenerating system to the control of oxidative phosphorylation in isolated rat‐liver mitochondria

1984 • 92 citations

Effects of thyroid hormone on mitochondrial oxidative phosphorylation

1985 • 91 citations

Measurement of the intramitochondrial volume in hepatocytes without cell disruption and its elevation by hormones and valinomycin

1983 • 89 citations

Effects of thyroxin on ultrastructure of rat myocardial cells: A stereological study

1973 • 89 citations

Stable enhancement of calcium retention in mitochondria isolated from rat liver after the administration of glucagon to the intact animal

1978 • 89 citations

Studies on the activation of rat liver pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase by adrenaline and glucagon. Role of increases in intramitochondrial Ca2+ concentration

1985 • 84 citations

Hormonal regulation of liver mitochondrial pyruvate carrier in relation to gluconeogenesis and lipogenesis

1976 • 84 citations

Relationship between chemiosmotic flows and thermodynamic forces in oxidative phosphorylation

1980 • 84 citations

Effects of glucagon and N6O2′-dibutyryladenosine 3′:5′-cyclic monophosphate on calcium transport in isolated rat liver mitochondria

1978 • 83 citations

The Calorigenic Nature of Hepatic Ketogenesis: An Explanation for the Stimulation of Respiration Induced by Fatty Acid Substrates

1983 • 83 citations

Relationship between Oxygen Uptake of Perifused Rat-Liver Cells and the Cytosolic Phosphorylation State Calculated from Indicator Metabolites and a Redetermined Equilibrium Constant

1978 • 81 citations

Differences between the Reactivity of Endogenous and Exogenous Adenine Nucleotides in Mitochondria as Studied at Low Temperature

1968 • 80 citations

A hypothesis for the mechanism of respiratory-chain phosphorylation not involving the electrochemical gradient of protons as obligatory intermediate

1985 • 80 citations

Relations between extramitochondrial and intramitochondrial adenine nucleotide systems

1981 • 78 citations

Thyroid control over biomembranes

1977 • 77 citations

The thyroid hormones A thesis concerning their action

1978 • 77 citations

Subcellular distribution of phosphagens in isolated perfused rat heart

1980 • 76 citations

Hormone-induced changes in NADH fluorescence and O2 consumption of rat hepatocytes

1982 • 75 citations

The hormonal stimulation of ureogenesis in isolated hepatocytes through increases in mitochondrial ATP production

1980 • 75 citations

Glucagon effects on the membrane potential and calcium uptake rate of rat liver mitochondria.

1984 • 74 citations

Insulin inhibition of α-adrenergic actions in liver

1981 • 73 citations

Quantification of fatty acid activation of the uncoupling protein in brown adipocytes and mitochondria from the guinea-pig

1986 • 72 citations

Studies on alpha-adrenergic-induced respiration and glycogenolysis in perfused rat liver.

1982 • 70 citations

Influence of fatty acids on energy metabolism

1984 • 70 citations

Influence of fatty acids on energy metabolism

1984 • 69 citations

Regulation of palmitoylcarnitine oxidation in isolated rat liver mitochondria. Role of the redox state of NAD(H)

1986 • 69 citations

Thyroid Hormone: Effects on Electron Transport

1966 • 69 citations

Stimulation of Mitochondrial Adenosine Diphosphate Uptake by Thyroid Hormones

1973 • 69 citations

The mitochondrial pyruvate carrier, its exchange properties and its regulation by glucagon

1976 • 69 citations

Metabolic responses of perfused rat livers to alpha- and beta-adrenergic agonists, glucagon and cyclic AMP

1975 • 69 citations

Effect of micromolar concentrations of free Ca2+ ions on pyruvate dehydrogenase interconversion in intact rat heart mitochondria

1981 • 69 citations

The α-adrenergic-mediated activation of the cardiac mitochondrial Ca2+ uniporter and its role in the control of intramitochondrial Ca2+in vivo

1983 • 68 citations

Effect of micromolar concentrations of free calcium ions on the reduction of heart mitochondrial NAD(P) by 2-oxoglutarate

1981 • 68 citations

Regulation of the degree of coupling of oxidative phosphorylation in intact rat liver

1985 • 68 citations

The stoichiometry of the exchange catalysed by the mitochondrial calcium/sodium antiporter

1985 • 68 citations

Thyrotoxicosis as a Disease of Mitochondria

1962 • 68 citations

Affinity and Reaction Rate Close to Equilibrium

1948 • 66 citations

Control of oxidative phosphorylations in yeast mitochondria. Role of the phosphate carrier

1986 • 66 citations

The effect of energization on the apparent Michaelis–Menten constant for oxyge in nmitochondrial respiration

1974 • 66 citations

The contribution of hepatic metabolism to diet-induced thermogenesis

1985 • 65 citations

Evidence for the existence of regulatory sites for Ca2+ on the Na+/Ca2+ carrier of cardiac mitochondria

1982 • 64 citations

Oxidative phosphorylation accompanying oxidation of short-chain fatty acids by rat-liver mitochondria

1966 • 64 citations

The mechanism of the hormonal activation of respiration in isolated hepatocytes and its importance in the regulation of gluconeogenesis

1986 • 64 citations

Adenine nucleotide translocation in liver mitochondria of hypothyroid rats

1977 • 64 citations

Localization of 3,5,3′-L-triiodothyronine receptor in rat kidney mitochondrial membranes

1982 • 63 citations

Control of energy transformation in mitochondria. Analysis by a quantitative model

1981 • 62 citations

The nature of the stimulation of the respiratory chain of rat liver mitochondria by glucagon pretreatment of animals

1982 • 61 citations

Rapid thyroid-hormone effect on mitochondrial and cytosolic ATP/ADP ratios in the intact liver cell

1985 • 61 citations

Role of Ca2+ ions in the regulation of intramitochondrial metabolism in rat epididymal adipose tissue. Evidence against a role for Ca2+ in the activation of pyruvate dehydrogenase by insulin

1984 • 60 citations

Mitochondrial transmembrane pH and electrical gradients: evaluation of their energy relationships with respiratory rate and ATP synthesis

1982 • 60 citations

Effect of membrane potential and pH gradient on electron transfer in cytochrome oxidase

1984 • 59 citations

Evidence for the rapid direct control both in vivo and in vitro of the efficiency of oxidative phosphorylation by 3,5,3′-tri-iodo-<scp>l</scp>-thyronine in rats

1979 • 59 citations

Efficiency of energy conversion in model biological pumps

1983 • 59 citations

Increased activity of phosphate-dependent glutaminase in liver mitochondria as a result of glucagon treatment of rats

1981 • 59 citations

Rate-controlling steps of oxidative phosphorylation in rat liver mitochondria. A synoptic approach of model and experiment

1982 • 59 citations

The nature of the changes in liver mitochondrial function induced by glucagon treatment of rats. The effects of intramitochondrial volume, aging and benzyl alcohol

1982 • 58 citations

Effect of phenylephrine on pyruvate dehydrogenase activity in rat hepatocytes and its interaction with insulin and glucagon

1983 • 57 citations

Dependence of mitochondrial oxidative phosphorylation on activity of the adenine nucleotide translocase.

1983 • 56 citations

The rôle of mitochondrial pyruvate transport in the stimulation by glucagon and phenylephrine of gluconeogenesis from <scp>l</scp>-lactate in isolated rat hepatocytes

1981 • 55 citations

The contribution of both extracellular and intracellular calcium to the action of α-adrenergic agonists in perfused rat liver

1984 • 55 citations

Studies of the effects of beta-adrenergic agonists on the regulation of pyruvate dehydrogenase in the perfused rat heart.

1980 • 55 citations

The effect of hormones on proton compartmentation in hepatocytes.

1984 • 54 citations

Activation of pyruvate dehydrogenase in the perfused rat liver by vasopressin

1978 • 54 citations

A model study of intracellular oxygen gradients in a myoglobin-containing skeletal muscle fiber

1986 • 54 citations

Hormones and liver mitochondria: Influence of growth hormone, thyroxine, testosterone, and insulin on thermotropic effects of respiration and fatty acid composition of membranes

1980 • 54 citations

ATP binding to bovine heart cytochrome c oxidase. A photoaffinity labelling study

1986 • 54 citations

Alterations in liver mitochondrial function as a result of fasting and exhaustive exercise

1984 • 53 citations

Effects of Glucagon on Glutamate Metabolism in the Perfused Rat Liver

1973 • 52 citations

Stimulation of the respiratory chain of rat liver mitochondria between cytochrome c1 and cytochrome c by glucagon treatment of rats

1978 • 52 citations

Regulation of the uncoupling protein in brown adipose tissue.

1986 • 52 citations

Evidence that Glucagon Stabilizes rather than Activates Mitochondrial Functions in Rat Liver

1981 • 51 citations

Effect of long-chain fatty acyl-CoA on mitochondrial and cytosolic ATP/ADP ratios in the intact liver cell

1984 • 50 citations

Glucagon-induced stimulation of 2-oxoglutarate metabolism in mitochondria from rat liver

1978 • 49 citations

Kinetics of Pi-Pi exchange in rat liver mitochondria. Rapid filtration experiments in the millisecond time range

1985 • 49 citations

The Stimulation of the Mitochondrial Uncoupler-Dependent ATPase in Isolated Hepatocytes by Catecholamines and Glucagon and Its Relationship to Gluconeogenesis

1979 • 49 citations

Glucagon-Stimulated Phosphorylation of Mitochondrial and Lysosomal Membranes of Rat Liver In Vivo

1972 • 48 citations

A re-evaluation of the role of mitochondrial pyruvate transport in the hormonal control of rat liver mitochondrial pyruvate metabolism

1984 • 47 citations

Thyroid hormone action on mitochondria

1968 • 47 citations

The control of uncoupler-activated ATPase activity in rat liver mitochondria by adenine nucleotide transport. The effect of glucagon treatment.

1980 • 47 citations

Early Kinetics of Glucagon Action in Isolated Hepatocytes at the Mitochondrial Level

1980 • 46 citations

Time course of alpha1-adrenergic and vasopressin actions on phosphorylase activation, calcium efflux, pyridine nucleotide reduction, and respiration in hepatocytes.

1983 • 46 citations

Stimulation of mitochondrial functions by glucagon treatment. Evidence that effects are not artifacts of mitochondrial isolation

1983 • 46 citations

The malate/aspartate shuttle and pyruvate kinase as targets involved in the stimulation of gluconeogenesis by phenylephrine

1986 • 46 citations

Thyrotoxicosis as a Disease of Mitochondria

1962 • 45 citations

The effects of glucagon, phenylephrine and insulin on the phosphorylation of cytoplasmic, mitochondrial and membrane-bound proteins of intact liver cells from starved rats

1982 • 45 citations

Thyroxine-induced changes in rat liver mitochondrial cytochromes

1985 • 45 citations

Evidence for β-adrenergic activation of Na+-dependent efflux of Ca2+ from isolated liver mitochondria

1982 • 44 citations

Activation of Succinate Dehydrogenase by Anions and pH

1974 • 44 citations

The influence of thyroxine administered in vivo on the transmembrane protonic electrochemical potential difference in rat liver mitochondria

1979 • 43 citations

Effects of Octanoate and Oleate on Energy Metabolism in the Perfused Rat Liver

1974 • 43 citations

Regulation of biosynthesis of the rat liver inner mitochondrial membrane by thyroid hormone

1984 • 43 citations

Stimulation of [1‐¹⁴C]oleate oxidation to ¹⁴CO₂ in isolated rat hepatocytes by vasopressin: effects of Ca²⁺

1980 • 42 citations

Intracellular Redox State and Stimulation of Gluconeogenesis by Glucagon and Norepinephrine in the Perfused Rat Liver

1980 • 42 citations

Respiration in Isolated Fat Cells and the Effects of Epinephrine

1968 • 42 citations

cis-Unsaturated fatty acids uncouple mitochondria and stimulate glycolysis in intact lymphocytes

1984 • 42 citations

The phosphate potential maintained by mitochondria in State 4 is proportional to the proton‐motive force

1985 • 41 citations

Rate control of phosphorylation-coupled respiration by rat liver mitochondria

1984 • 41 citations

Redox‐linked proton translocation in the b–c₁ complex from beef‐heart mitochondria reconstituted into phospholipid vesicles

1983 • 40 citations

The Control of Pyruvate Oxidation in a Cell-free Rat Heart Preparation by Phosphate Acceptors

1951 • 40 citations

Glucocorticoid-stimulated utilization of substrates in hepatic mitochondria

1977 • 40 citations

Investigation of the dependence of the intramitochondrial [ATP]/[ADP] ratio on the respiration rate

1980 • 39 citations

Partial uncoupling, or inhibition of electron transport rate, have equivalent effects on the relationship between the rate of ATP synthesis and proton‐motive force in submitochondrial particles

1985 • 39 citations

Interaction of Ca2+ and H+ with heme A in cytochrome oxidase

1980 • 39 citations

The α-adrenergic-mediated activation of Ca2+ influx into cardiac mitochondria. A possible mechanism for the regulation of intramitochondrial free CA2+

1981 • 39 citations

The effect of glucagon on hepatic respiratory capacity.

1984 • 39 citations

Rat liver mitochondria prepared in mannitol media demonstrate increased mitochondrial volumes compared with mitochondria prepared in sucrose media. Relationship to the effect of glucagon on mitochondrial function

1984 • 39 citations

Interaction between F1-ATPase and its naturally occurring inhibitor protein. Studies using a specific anti-inhibitor antibody

1985 • 38 citations

The activation of Na+-dependent efflux of Ca2+ from liver mitochondria by glucagon and β-adrenergic agonists

1983 • 38 citations

Electroneutral efflux of Ca2+ from liver mitochondria

1985 • 38 citations

Rapid action of glucagon on hepatic mitochondrial calcium metabolism and respiratory rates

1980 • 37 citations

Hormone-initiated maturation of rat liver mitochondria after birth

1980 • 37 citations

Decreased flux through pyruvate dehydrogenase during calcium ion movements induced by vasopressin, α-adrenergic agonists and the ionophore A23187 in perfused rat liver

1983 • 37 citations

Short‐term control of mitochondrial adenine nucleotide translocator by thyroid hormone

1984 • 37 citations

Glucagon stimulation of mitochondrial ATPase and potassium ion transport

1977 • 36 citations

Influence of Isolation Media on the Preservation of Mitochondrial Functions

1983 • 35 citations

The role of malate in exercise-induced enhancement of mitochondrial respiration

1986 • 35 citations

The function of energy‐dependent redox reactions in cell metabolism

1980 • 35 citations

The effects of alpha-adrenergic agonists on the regulation of the branched chain alpha-ketoacid oxidation in the perfused rat liver.

1982 • 34 citations

Effect of Growth Hormone on Mitochondrial Protein Synthesis

1973 • 34 citations

Hormonal control of pyruvate dehydrogenase activity in rat liver

1984 • 34 citations

Comparative Studies on the Influence of Hormones on Metabolite Compartmentation in Isolated Liver Cells during Gluconeogenesis from Lactate

1978 • 34 citations

Evidence that adrenaline activates key oxidative enzymes in rat liver by increasing intramitochondrial [Ca²⁺]

1985 • 33 citations

Mechanism of activation of pyruvate dehydrogenase by mitogens in pig lymphocytes

1983 • 33 citations

Thyroid hormone-divalent cation interactions

1978 • 32 citations

Isolated hepatocytes as a model for the study of stable glucagon effects on mitochondrial respiratory functions

1979 • 32 citations

The Influence of the Ionic Conductance on the Relation between Electron Transport and Proton‐Motive Force in Intact Cells of Rhodopseudomonas capsulata

1983 • 32 citations

Metabolic control by pump slippage and proton leakage in ‘delocalized’ and more localized chemiosmotic energy-coupling schemes

1983 • 32 citations

α-adrenergic stimulation of respiration in isolated rat hepatocytes

1983 • 31 citations

Steady-state H+/O stoichiometry of liver mitochondria

1981 • 31 citations

Mechanism of the stimulation of respiration by fatty acids in rat liver

1985 • 31 citations

Multiple relationships between rate of oxidative phosphorylation and Δµ̃H in rat liver mitochondria

1985 • 30 citations

cis-Unsaturated fatty acids inhibit cap formation on lymphocytes by depleting cellular ATP.

1980 • 30 citations

Hormonal stimulation of mitochondrial pyruvate carboxylation in filipin-treated hepatocytes

1983 • 30 citations

Control of electron transfer in the cytochrome system of mitochondria by pH, transmembrane pH gradient and electrical potential. The cytochromes b-c segment

1981 • 30 citations

Hormones and liver mitochondria: Effects of growth hormone and thyroxine on respiration, fluorescence of 1-anilino-8-naphthalene sulfonate and enzyme activities of complex I and II of submitochondrial particles

1981 • 29 citations

Reversibility of Energy Transformations in the Respiratory Chain

1964 • 28 citations

The influence of thyroid hormone on the degree of control of oxidative phosphorylation exerted by the adenine nucleotide translocator

1984 • 28 citations

Ca²⁺‐dependent inhibition by trifluoperazine of the Na⁺‐Ca²⁺ carrier in mitoplasts derived from heart mitochondria

1985 • 27 citations

Effect of thyroidectomy on the kinetics of ADP-ATP translocation in liver mitochondria

1983 • 27 citations

Mechanisms involved in hormone signal transduction across the mitochondrial membrane

1985 • 26 citations

The relationship between the rate of respiration and the protonmotive force. The role of proton conductivity

1984 • 26 citations

Glucagon treatment stimulates the oxidation of durohydroquinone by rat liver mitochondria

1979 • 25 citations

Effects of glucagon on the redox states of cytochromes in mitochondria insitu in perfused rat liver

1984 • 25 citations

The oxidation-state-dependent ATP-binding site of cytochrome c. A possible physiological significance

1986 • 24 citations

Regulation of H+-ATPases in oxidative- and photophosphorylation

1986 • 24 citations

Free energy coupling between H⁺‐generating and H⁺‐consuming pumps

1986 • 23 citations

Effect of growth hormone on fatty acid oxidation: Growth hormone increases the activity of 2,4-dienoyl-CoA reductase in mitochondria

1986 • 22 citations

The steady state activity of succinate dehydrogenase in the presence of opposing effectors

1975 • 22 citations

Kinetic analysis of short‐term effects of α‐agonists on gluconeogenesis in isolated rat hepatocytes

1985 • 22 citations

Ca2+ -dependent activation of oxoglutarate dehydrogenase by vasopressin in isolated hepatocytes

1985 • 21 citations

The thermodynamic basis for the partial control of oxidative phosphorylation by the adenine-nucleotide translocator

1983 • 21 citations

Possible role of Pi supply in mitochondrial actions of glucagon

1984 • 20 citations

Reconstruction of steady state in cell-free systems

1983 • 20 citations

Glucagon stimulation of liver mitochondrial CO2 fixation utilizing pyruvate generated inside the mitochondria.

1979 • 20 citations

The effect of β-adrenergic agonists on the membrane potential of fat-cell mitochondria in situ

1982 • 20 citations

The stimulation of tricarboxylic acid-cycle flux by α-adrenergic agonists in perfused rat liver

1986 • 19 citations

The role of malate in hormone-induced enhancement of mitochondrial respiration

1986 • 19 citations

α‐Adrenergic Stimulation of Glycolysis and Na⁺, K⁺‐Transport in Perfused Rat Liver

1982 • 18 citations

On the nature of the stimulation by glucagon on citrulline synthesis in rat‐liver mitochondria

1982 • 18 citations

Evidence that glucagon acts on the liver to decrease mitochondrial calcium stores

1983 • 18 citations

A critical appraisal of evidence for localized energy coupling. Kinetic studies on liposomes containing bacteriorhodopsin and ATP synthase

1985 • 17 citations

The efficiency of oxidative phosphorylation and the rapid control by thyroid hormone of nicotinamide nucleotide reduction and transhydrogenation in intact rat liver mitochondria

1984 • 17 citations

The thyroid gland and the liver mitochondrial protonic electrochemical potential difference: A novel hormone action?

1980 • 17 citations

Ion transport in liver mitochondria from normal and thyroxine-treated rats

1980 • 16 citations

On the stimulation of respiration by α‐adrenergic agonists in perfused rat liver

1986 • 15 citations

Measurement of ketone bodies in subcellular fractions using a spectrophotometric iron-chelate assay

1982 • 15 citations

Triphenylmethylphosphonium cation distribution as a measure of hormone-induced alterations in white adipocyte membrane potential

1982 • 14 citations

DNA polymerase γ, cytochrome c oxidase and mitochondrial integrity in rabbit spleen lymphocytes stimulated with concanavalin A

1980 • 13 citations

The Calcium Carriers of Mitochondria

1985 • 12 citations

Glucagon‐stimulated respiration and intracellular Ca²⁺

1986 • 12 citations

The effect of glucagon and adrenergic agonists on intracellular pH of isolated rat hepatocytes.

1985 • 11 citations

Different Actions of Mono- and Disaccharides on Rat Liver Mitochondria

1983 • 11 citations

A second site of vasopressin action on [1-14C]oleate metabolism in isolated rat hepatocytes: Increased formation of 14CO2

1980 • 11 citations

On the hormonal control of heart mitochondrial Ca2+.

1985 • 10 citations

Mechanism of the stimulation of respiration by added substrate in hepatocytes

1986 • 10 citations

α,β-Bidentate CrADP abolishes the negative cooperativity of yeast mitochondrial F1-ATPase

1985 • 10 citations

Alterations of oxidative phosphorylation reactions in mitochondria isolated from hypothyroid rat liver

1984 • 9 citations

Effect of thyroidectomy on oxidative phosphorylation mechanisms in rat liver mitochondria

1982 • 9 citations

On the question of stable activation by glucagon of mitochondrial functions

1985 • 7 citations

Control of respiration in sonicated cytochrome oxidase proteoliposomes by gated and ungated ionophores

1985 • 7 citations

Increased adenine nucleotides in liver mitochondria after mannoheptulose injection in vivo

1986 • 6 citations

Comparative effects of thyroid hormone analogs on the activities of brain and liver mitochondria and nuclei in thyroidectomized rats

1984 • 5 citations

Thyroid-hormone control of nicotinamide nucleotide redox reactions in liver mitochondria

1983 • 4 citations

The control of electron flux through cytochrome oxidase

1986 • 4 citations

Association of glycolytic enzymes with the erythrocyte membrane

1981 • 3 citations

The rapid physiological control of rat liver oxidative phosphorylation by tri-iodo-<scp>l</scp>-thyronine

1985 • 3 citations

Thermodynamic Analysis of Biomembrane Energy Transduction

1982 • 3 citations

The mitochondrial protonic electrochemical potential difference as a point of hormone action. II. New proposals for the activity of glucagon

1981 • 3 citations

Control of Mitochondrial Respiration

1985 • 2 citations

The measurement of liver mitochondrial electrochemical potential in situ and the effects of glucagon

1985 • 2 citations

EFFECTS OF GLUCAGON AND PHENYLEPHRINE ON ΔpH AND Δψ IN INTACT HEPATOCYTES AND ISOLATED LIVER MITOCHONDRIA IN RELATION TO Ca2+ TRANSPORT

1981 • 2 citations

Vasopressin and glucagon activate key oxidative enzymes in rat liver by increasing intramitochondrial [Ca2+]

1985 • 1 citations

Cytochrome changes in control and concanavalin A-stimulated lymphocytes

1982 • 1 citations