Mitochondrial Function in the Heart

The Influence of Respiration and ATP Hydrolysis on the Proton‐Electrochemical Gradient across the Inner Membrane of Rat‐Liver Mitochondria as Determined by Ion Distribution

1974 • 707 citations

Regulation of pyruvate dehydrogenase in rat heart. Mechanism of regulation of proportions of dephosphorylated and phosphorylated enzyme by oxidation of fatty acids and ketone bodies and of effects of diabetes: role of coenzyme A, acetyl-coenzyme A and reduced and oxidized nicotinamide-adenine dinucleotide

1976 • 399 citations

α-KETO ACID DEHYDROGENASE COMPLEXES, XI. COMPARATIVE STUDIES OF REGULATORY PROPERTIES OF THE PYRUVATE DEHYDROGENASE COMPLEXES FROM KIDNEY, HEART, AND LIVER MITOCHONDRIA

1969 • 355 citations

Control of fatty acid metabolism in ischemic and hypoxic hearts.

1978 • 328 citations

Acetoacetate as fuel of respiration in the perfused rat heart

1961 • 298 citations

Control of the tricarboxylate cycle and its interactions with glycolysis during acetate utilization in rat heart

1970 • 270 citations

Acyl-CoA inhibition of adenine nucleotide translocation in ischemic myocardium

1975 • 267 citations

Changes in tissue levels of carnitine and other metabolites during myocardial ischemia and anoxia

1978 • 249 citations

Regulation of Fatty Acid Utilization in Isolated Perfused Rat Hearts

1973 • 222 citations

The phosphorylation potential generated by respiring mitochondria

1973 • 212 citations

Relation between the Gradient of the ATP/ADP Ratio and the Membrane Potential across the Mitochondrial Membrane

1977 • 210 citations

Pyridine nucleotide distributions and enzyme mass action ratios in hepatocytes from fed and starved rats

1977 • 208 citations

Feedback Interactions in the Control of Citric Acid Cycle Activity in Rat Heart Mitochondria

1972 • 179 citations

Regulation of Glutamate Metabolism and Interactions with the Citric Acid Cycle in Rat Heart Mitochondria

1973 • 158 citations

Electrogenic Characteristics of the Mitochondrial Glutamate-Aspartate Antiporter

1974 • 153 citations

31P nuclear magnetic resonance studies of isolated rat liver cells

1978 • 152 citations

Re-evaluation of the H+/site ratio of mitochondrial electron transport with the oxygen pulse technique.

1976 • 140 citations

Inhibition of bovine heart Na+,K+-ATPase by palmitylcarnitine and palmityl-CoA

1977 • 133 citations

Thermodynamic relationships between the oxidation-reduction reactions and the ATP synthesis in suspensions of isolated pigeon heart mitochondria

1974 • 126 citations

Interconversion of pyruvate dehydrogenase in rat heart muscle upon perfusion with fatty acids or ketone bodies

1971 • 120 citations

Studies on the effects of coenzyme A-SH: acetyl coenzyme A, nicotinamide adenine dinucleotide: reduced nicotinamide adenine dinucleotide, and adenosine diphosphate: adenosine triphosphate ratios on the interconversion of active and inactive pyruvate dehydrogenase in isolated rat heart mitochondria.

1976 • 117 citations

Control of respiration in isolated mitochondria: Quantitative evaluation of the dependence of respiratory rates on [ATP], [ADP], and [Pi]

1977 • 116 citations

Evaluation of the H+/site ratio of mitochondrial electron transport from rate measurements.

1976 • 115 citations

Homeostatic regulation of cellular energy metabolism: experimental characterization in vivo and fit to a model

1978 • 110 citations

Inter-Relationships between Proton Electrochemical Gradient, Adenine-Nucleotide Phosphorylation Potential and Respiration, during Substrate-Level and Oxidative Phosphorylation by Mitochondria from Brown Adipose Tissue of Cold-Adapted Guinea-Pigs

1977 • 105 citations

Proton electrochemical gradient and rate of controlled respiration in mitochondria

1978 • 102 citations

Coordination of citric acid cycle activity with electron transport flux.

1976 • 97 citations

Proton electrochemical gradient and phosphate potential in mitochondria

1978 • 94 citations

Studies with Isolated Surviving Rat Hearts

1973 • 93 citations

Control of mitochondrial metabolism by the ATPADP ratio

1978 • 90 citations

Effects of mechanical activity and hormones on myocardial glucose and fatty acid utilization.

1976 • 85 citations

Conformational changes in cytochromeaa 3 and ATP synthetase of the mitochondrial membrane and their role in mitochondrial energy transduction

1976 • 42 citations

Respiratory acidosis and its reversibility in perfused rat heart: regulation of citric acid cycle activity

1978 • 37 citations

The nature of controlled respiration and its relationship to protonmotive force and proton conductance in blowfly flight-muscle mitochondria

1977 • 28 citations

FEEDBACK CONTROL OF THE CITRIC ACID CYCLE

1972 • 21 citations

Structure, Function and Regulation of the Mammalian Pyruvate Dehydrogenase Complex

1974 • 16 citations

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