Protein phosphatase 1 can modulate alternative 5′ splice site selection in a HeLa splicing extract

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DNA sequencing with chain-terminating inhibitors

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1992 • 766 citations

Regulation of alternative pre-mRNA splicing by hnRNP A1 and splicing factor SF2

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ALTERNATIVE SPLICING IN THE CONTROL OF GENE EXPRESSION

1989 • 701 citations

Functional expression of cloned human splicing factor SF2: homology to rna-binding proteins, U1 70K, and drosophila splicing regulators

1991 • 508 citations

A protein factor, ASF, controls cell-specific alternative splicing of SV40 early pre-mRNA in vitro

1990 • 500 citations

The essential pre-mRNA splicing factor SF2 influences 5′ splice site selection by activating proximal sites

1990 • 454 citations

Distinct Functions of SR Proteins in Alternative pre-mRNA Splicing

1993 • 407 citations

Structure of spliceosomal snRNPs and their role in pre-mRNA splicing

1990 • 407 citations

Primary structure of the human splicing factor asf reveals similarities with drosophila regulators

1991 • 357 citations

A conserved family of nuclear phosphoproteins localized to sites of polymerase II transcription.

1991 • 344 citations

General splicing factors SF2 and SC35 have equivalent activities in vitro, and both affect alternative 5' and 3' splice site selection.

1992 • 241 citations

Ser/Thr-specific protein phosphatases are required for both catalytic steps of pre-mRNA splicing

1992 • 209 citations

Pre-mRNA Splicing in Yeast

1989 • 209 citations

A monoclonal antibody that recognizes a phosphorylated epitope stains lampbrush chromosome loops and small granules in the amphibian germinal vesicle.

1990 • 193 citations

Inhibitor‐2 functions like a chaperone to fold three expressed isoforms of mammalian protein phosphatase‐1 into a conformation with the specificity and regulatory properties of the native enzyme

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Thiophosphorylation of U1-70K protein inhibits pre-mRNA splicing

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Targeted snRNP depletion reveals an additional role for mammalian U1 snRNP in spliceosome assembly

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Two members of a conserved family of nuclear phosphoproteins are involved in pre-mRNA splicing.

1992 • 131 citations

Probing the structure and function of U2 snRNP with antisense oligonucleotides made of 2′-OMe RNA

1989 • 115 citations

Phosphorylation of human hnRNP protein A1 abrogatesin vitrostrand annealing activity

1993 • 91 citations

The Spliceosome

1993 • 80 citations

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1993 • 71 citations

Sequence of human protein serine/threonine phosphatase 1 gamma and localization of the gene (PPP1CC) encoding it to chromosome bands 12q24.1–q24.2

1993 • 61 citations

Adenosine phosphorothioates (ATP alpha S and ATP tau S) differentially affect the two steps of mammalian pre-mRNA splicing.

1992 • 53 citations