Dicing and slicing

MicroRNAs

2004 • 33,206 citations

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

1998 • 14,674 citations

The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14

1993 • 12,238 citations

Role for a bidentate ribonuclease in the initiation step of RNA interference

2001 • 4,804 citations

Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans

1993 • 4,021 citations

RNA interference is mediated by 21- and 22-nucleotide RNAs

2001 • 3,271 citations

MicroRNAs Modulate Hematopoietic Lineage Differentiation

2003 • 3,241 citations

An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells

2000 • 2,945 citations

Asymmetry in the Assembly of the RNAi Enzyme Complex

2003 • 2,761 citations

The Microprocessor complex mediates the genesis of microRNAs

2004 • 2,625 citations

A Cellular Function for the RNA-Interference Enzyme Dicer in the Maturation of the let-7 Small Temporal RNA

2001 • 2,623 citations

Argonaute2 Is the Catalytic Engine of Mammalian RNAi

2004 • 2,620 citations

Processing of primary microRNAs by the Microprocessor complex

2004 • 2,617 citations

RNAi

2000 • 2,596 citations

Functional siRNAs and miRNAs Exhibit Strand Bias

2003 • 2,516 citations

MicroRNA biogenesis: coordinated cropping and dicing

2005 • 2,443 citations

RNA silencing in plants

2004 • 2,393 citations

c-Myc-regulated microRNAs modulate E2F1 expression

2005 • 2,371 citations

The Drosha-DGCR8 complex in primary microRNA processing

2004 • 2,096 citations

Dicer is essential for mouse development

2003 • 1,896 citations

Human Argonaute2 Mediates RNA Cleavage Targeted by miRNAs and siRNAs

2004 • 1,887 citations

Genes and Mechanisms Related to RNA Interference Regulate Expression of the Small Temporal RNAs that Control C. elegans Developmental Timing

2001 • 1,847 citations

Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans

2001 • 1,761 citations

Argonaute2, a Link Between Genetic and Biochemical Analyses of RNAi

2001 • 1,492 citations

Single-Stranded Antisense siRNAs Guide Target RNA Cleavage in RNAi

2002 • 1,422 citations

Inhibition of Translational Initiation by Let-7 MicroRNA in Human Cells

2005 • 1,408 citations

Crystal Structure of Argonaute and Its Implications for RISC Slicer Activity

2004 • 1,406 citations

Decapping and Decay of Messenger RNA Occur in Cytoplasmic Processing Bodies

2003 • 1,323 citations

Regulation by let-7 and lin-4 miRNAs Results in Target mRNA Degradation

2005 • 1,311 citations

The rde-1 Gene, RNA Interference, and Transposon Silencing in C. elegans

1999 • 1,286 citations

Distinct Roles for Drosophila Dicer-1 and Dicer-2 in the siRNA/miRNA Silencing Pathways

2004 • 1,254 citations

MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies

2005 • 1,210 citations

ATP Requirements and Small Interfering RNA Structure in the RNA Interference Pathway

2001 • 1,008 citations

Single Processing Center Models for Human Dicer and Bacterial RNase III

2004 • 985 citations

A Role for the RNase III Enzyme DCR-1 in RNA Interference and Germ Line Development in Caenorhabditis elegans

2001 • 853 citations

Targeted mRNA degradation by double-stranded RNA in vitro

1999 • 845 citations

Distinct roles for Argonaute proteins in small RNA-directed RNA cleavage pathways

2004 • 831 citations

The Human DiGeorge Syndrome Critical Region Gene 8 and Its D. melanogaster Homolog Are Required for miRNA Biogenesis

2004 • 815 citations

Purified Argonaute2 and an siRNA form recombinant human RISC

2005 • 736 citations

Structural basis for overhang-specific small interfering RNA recognition by the PAZ domain

2004 • 717 citations

R2D2, a Bridge Between the Initiation and Effector Steps of the Drosophila RNAi Pathway

2003 • 690 citations

Fragile X-related protein and VIG associate with the RNA interference machinery

2002 • 646 citations

Argonaute 2/RISC resides in sites of mammalian mRNA decay known as cytoplasmic bodies

2005 • 631 citations

Structural basis for 5′-end-specific recognition of guide RNA by the A. fulgidus Piwi protein

2005 • 629 citations

Human Dicer preferentially cleaves dsRNAs at their termini without a requirement for ATP

2002 • 622 citations

A Protein Sensor for siRNA Asymmetry

2004 • 584 citations

A Drosophila fragile X protein interacts with components of RNAi and ribosomal proteins

2002 • 573 citations

The crystal structure of the Argonaute2 PAZ domain reveals an RNA binding motif in RNAi effector complexes

2003 • 569 citations

RNA as a target of double-stranded RNA-mediated genetic interference in Caenorhabditis elegans

1998 • 561 citations

Recognition and cleavage of primary microRNA precursors by the nuclear processing enzyme Drosha

2004 • 554 citations

The dsRNA Binding Protein RDE-4 Interacts with RDE-1, DCR-1, and a DExH-Box Helicase to Direct RNAi in C. elegans

2002 • 538 citations

Normal microRNA Maturation and Germ-Line Stem Cell Maintenance Requires Loquacious, a Double-Stranded RNA-Binding Domain Protein

2005 • 537 citations

Structural insights into mRNA recognition from a PIWI domain–siRNA guide complex

2005 • 518 citations

Purification and Properties of Ribonuclease III from Escherichia coli

1968 • 473 citations

Structure and conserved RNA binding of the PAZ domain

2003 • 468 citations

A micrococcal nuclease homologue in RNAi effector complexes

2003 • 451 citations

Structure and nucleic-acid binding of the Drosophila Argonaute 2 PAZ domain

2003 • 442 citations

Double-Stranded RNA as a Template for Gene Silencing

2000 • 421 citations

Processing of Pre-microRNAs by the Dicer-1–Loquacious Complex in Drosophila Cells

2005 • 421 citations

A Dicer-2-Dependent 80S Complex Cleaves Targeted mRNAs during RNAi in Drosophila

2004 • 417 citations

RISC is a 5′ phosphomonoester-producing RNA endonuclease

2004 • 409 citations

RISC Assembly Defects in the Drosophila RNAi Mutant armitage

2004 • 377 citations

Crystal structure of a PIWI protein suggests mechanisms for siRNA recognition and slicer activity

2004 • 342 citations

Nucleic acid 3′-end recognition by the Argonaute2 PAZ domain

2004 • 342 citations

Biochemical identification of Argonaute 2 as the sole protein required for RNA-induced silencing complex activity

2004 • 317 citations

Efficient Processing of Primary microRNA Hairpins by Drosha Requires Flanking Nonstructured RNA Sequences

2005 • 297 citations

The RNA-Induced Silencing Complex Is a Mg2+-Dependent Endonuclease

2004 • 261 citations

Crystallographic and Modeling Studies of RNase III Suggest a Mechanism for Double-Stranded RNA Cleavage

2001 • 230 citations

Short-Interfering-RNA-Mediated Gene Silencing in Mammalian Cells Requires Dicer and eIF2C Translation Initiation Factors

2003 • 224 citations

Patterns of flanking sequence conservation and a characteristic upstream motif for microRNA gene identification

2004 • 192 citations

RNAi: A Guide to Gene Silencing

2003 • 141 citations

Noncatalytic Assembly of Ribonuclease III with Double-Stranded RNA

2004 • 122 citations

An siRNA ribonucleoprotein is found associated with polyribosomes in Trypanosoma brucei

2003 • 57 citations

Thirty-Three Years Later, a Glimpse at the Ribonuclease III Active Site

2001 • 35 citations