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Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

1997 • 71,835 citations

MicroRNAs

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Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes

2002 • 18,672 citations

The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14

1993 • 12,238 citations

Prediction of Mammalian MicroRNA Targets

2003 • 5,070 citations

The nuclear RNase III Drosha initiates microRNA processing

2003 • 4,966 citations

Identification of Novel Genes Coding for Small Expressed RNAs

2001 • 4,834 citations

The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans

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Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans

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MicroRNAs Modulate Hematopoietic Lineage Differentiation

2003 • 3,241 citations

An Abundant Class of Tiny RNAs with Probable Regulatory Roles in Caenorhabditis elegans

2001 • 3,225 citations

An Extensive Class of Small RNAs in Caenorhabditis elegans

2001 • 2,806 citations

MicroRNA maturation: stepwise processing and subcellular localization

2002 • 2,410 citations

Computational Identification of Plant MicroRNAs and Their Targets, Including a Stress-Induced miRNA

2004 • 2,226 citations

bantam Encodes a Developmentally Regulated microRNA that Controls Cell Proliferation and Regulates the Proapoptotic Gene hid in Drosophila

2003 • 2,012 citations

TRANSFAC(R): transcriptional regulation, from patterns to profiles

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A uniform system for microRNA annotation

2003 • 1,841 citations

MicroRNAs in plants

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MicroRNA-Directed Cleavage of HOXB8 mRNA

2004 • 1,680 citations

Micro RNAs are complementary to 3′ UTR sequence motifs that mediate negative post-transcriptional regulation

2002 • 1,426 citations

Non–coding RNA genes and the modern RNA world

2001 • 1,407 citations

Identifying DNA and protein patterns with statistically significant alignments of multiple sequences.

1999 • 1,272 citations

CARPEL FACTORY, a Dicer Homolog, and HEN1, a Novel Protein, Act in microRNA Metabolism in Arabidopsis thaliana

2002 • 1,243 citations

The microRNAs ofCaenorhabditis elegans

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MicroRNA Pathways in Flies and Worms

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Vertebrate MicroRNA Genes

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An extensive network of coupling among gene expression machines

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Predictive Identification of Exonic Splicing Enhancers in Human Genes

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The Genome Sequence of Caenorhabditis briggsae: A Platform for Comparative Genomics

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The Small RNA Profile during Drosophila melanogaster Development

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Endogenous and Silencing-Associated Small RNAs in Plants[W]

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New microRNAs from mouse and human

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The Cold Shock Domain Protein LIN-28 Controls Developmental Timing in C. elegans and Is Regulated by the lin-4 RNA

1997 • 844 citations

Both Natural and Designed Micro RNAs Can Inhibit the Expression of Cognate mRNAs When Expressed in Human Cells

2002 • 824 citations

A microRNA controlling left/right neuronal asymmetry in Caenorhabditis elegans

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Novel small RNA-encoding genes in the intergenic regions of Escherichia coli

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Computational identification of DrosophilamicroRNA genes

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MicroRNAs and Other Tiny Endogenous RNAs in C. elegans

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Unsupervised learning of multiple motifs in biopolymers using expectation maximization

1995 • 680 citations

The expanding snoRNA world

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Synergistic activation by the glutamine-rich domains of human transcription factor Sp1

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Sequence requirements for micro RNA processing and function in human cells

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Computational analysis of core promoters in the Drosophila genome

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The Caenorhabditis elegans hunchback-like Gene lin-57/hbl-1 Controls Developmental Time and Is Regulated by MicroRNAs

2003 • 370 citations

A computational analysis of sequence features involved in recognition of short introns

2001 • 368 citations

RNA-binding protein Nrd1 directs poly(A)-independent 3′-end formation of RNA polymerase II transcripts

2001 • 365 citations

The C. elegans hunchback Homolog, hbl-1, Controls Temporal Patterning and Is a Probable MicroRNA Target

2003 • 354 citations

Temporal regulation of microRNA expression in Drosophila melanogaster mediated by hormonal signals and Broad-Complex gene activity

2003 • 316 citations

Computational and Experimental Identification of C. elegans microRNAs

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Ensembl 2002: accommodating comparative genomics

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Comparative Analysis of Noncoding Regions of 77 Orthologous Mouse and Human Gene Pairs

1999 • 218 citations

Tissue-specific expression of the human growth hormone gene is conferred in part by the binding of a specific trans-acting factor.

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A statistical method for finding transcription factor binding sites.

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Identification and analysis of eukaryotic promoters: recent computational approaches

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The time of appearance of the C. elegans let-7 microRNA is transcriptionally controlled utilizing a temporal regulatory element in its promoter

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Bayesian adaptive sequence alignment algorithms.

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WormBase: a cross-species database for comparative genomics

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Analysis of similarity within 142 pairs of orthologous intergenic regions of Caenorhabditis elegans and Caenorhabditis briggsae

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