Suppression of ras-mediated transformation and inhibition of tumor growth and angiogenesis by anthrax lethal factor, a proteolytic inhibitor of multiple MEK pathways

PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo

1995 • 3,456 citations

Identification of a Novel Inhibitor of Mitogen-activated Protein Kinase Kinase

1998 • 3,026 citations

A synthetic inhibitor of the mitogen-activated protein kinase cascade.

1995 • 2,723 citations

Signal Transduction through MAP Kinase Cascades

1998 • 1,762 citations

Transformation of Mammalian Cells by Constitutively Active MAP Kinase Kinase

1994 • 1,370 citations

Proteolytic Inactivation of MAP-Kinase-Kinase by Anthrax Lethal Factor

1998 • 1,003 citations

Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo

1999 • 970 citations

Anthrax toxin edema factor: a bacterial adenylate cyclase that increases cyclic AMP concentrations of eukaryotic cells.

1982 • 929 citations

p38 MAP kinase activation by vascular endothelial growth factor mediates actin reorganization and cell migration in human endothelial cells

1997 • 847 citations

Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumors

1999 • 688 citations

Hyperexpression of mitogen-activated protein kinase in human breast cancer.

1997 • 454 citations

Anthrax Lethal Factor Cleaves the N-Terminus of MAPKKs and Induces Tyrosine/Threonine Phosphorylation of MAPKs in Cultured Macrophages

1998 • 402 citations

Integrin αvβ3 Requirement for Sustained Mitogen-activated Protein Kinase Activity during Angiogenesis

1998 • 397 citations

VEGF Prevents Apoptosis of Human Microvascular Endothelial Cells via Opposing Effects on MAPK/ERK and SAPK/JNK Signaling

1999 • 374 citations

Enhanced Tumorigenicity and Invasion-Metastasis by Hepatocyte Growth Factor/Scatter Factor-Met Signalling in Human Cells Concomitant with Induction of the Urokinase Proteolysis Network

1996 • 312 citations

Anthrax toxin lethal factor contains a zinc metalloprotease consensus sequence which is required for lethal toxin activity

1994 • 310 citations

Anthrax lethal factor cleaves MKK3 in macrophages and inhibits the LPS/IFNγ‐induced release of NO and TNFα

1999 • 296 citations

Differences in susceptibility of inbred mice to Bacillus anthracis

1986 • 282 citations

MAP kinases, phosphatidylinositol 3-kinase, and p70 S6 kinase mediate the mitogenic response of human endothelial cells to vascular endothelial growth factor

1999 • 213 citations

Purification of Factor I and Recognition of a Third Factor of the Anthrax Toxin

1961 • 202 citations

RAPID LETHAL EFFECT IN RATS OF A THIRD COMPONENT FOUND UPON FRACTIONATING THE TOXIN OF BACILLUS ANTHRACIS

1962 • 199 citations

Signaling pathways in Ras-mediated tumorigenicity and metastasis

1998 • 194 citations

Platelet-derived Growth Factor and Fibronectin-stimulated Migration Are Differentially Regulated by the Rac and Extracellular Signal-regulated Kinase Pathways

1997 • 173 citations

Immunoelectrophoretic analysis, toxicity, and kinetics of in vitro production of the protective antigen and lethal factor components of Bacillus anthracis toxin

1984 • 144 citations

Anthrax lethal factor cleaves the N-terminus of MAPKKS and induces tyrosine/threonine phosphorylation of MAPKS in cultured macrophages

1999 • 142 citations

Characterization and molecular cloning of a putative binding protein for heparin-binding growth factors.

1991 • 135 citations

Ras-responsive genes and tumor metastasis.

1993 • 127 citations

Tumor growth and angiogenesis induced by a secreted binding protein for fibroblast growth factors.

1994 • 125 citations

In Situ Visualization of Intratumor Growth Factor Signaling

1998 • 125 citations

Synergy between the Mos/Mitogen-Activated Protein Kinase Pathway and Loss of p53 Function in Transformation and Chromosome Instability

1997 • 119 citations

A Specific Activation of the Mitogen-Activated Protein Kinase Kinase 1 (Mek1) Is Required for Golgi Fragmentation during Mitosis

2000 • 99 citations

Angiostatin Diminishes Activation of the Mitogen-Activated Protein Kinases ERK-1 and ERK-2 in Human Dermal Microvascular Endothelial Cells

1999 • 89 citations

Genes that regulate metastasis and angiogenesis.

2000 • 86 citations

Induction of the Angiogenic Modulator Fibroblast Growth Factor-binding Protein by Epidermal Growth Factor Is Mediated through Both MEK/ERK and p38 Signal Transduction Pathways

2000 • 83 citations

PRODUCTION OF TOXIN IN VITRO BY BACILLUS ANTHRACIS AND ITS SEPARATION INTO TWO COMPONENTS

1960 • 67 citations

Ras Signals to the Cell Cycle Machinery via Multiple Pathways To Induce Anchorage-Independent Growth

1998 • 63 citations

CENP-E is an essential kinetochore motor in maturing oocytes and is masked during Mos-dependent, cell cycle arrest at metaphase II

1997 • 62 citations

Role of Mitogen-activated Protein Kinases and c-Jun/AP-1 trans-Activating Activity in the Regulation of Protease mRNAs and the Malignant Phenotype in NIH 3T3 Fibroblasts

1999 • 61 citations

Anthrax toxins

1999 • 59 citations

Purification of Factors I and II of the Anthrax Toxin Produced in vivo

1960 • 58 citations

U0126 reverses Ki-ras-mediated transformation by blocking both mitogen-activated protein kinase and p70 S6 kinase pathways.

2000 • 57 citations

Characterization of Downstream Ras Signals That Induce Alternative Protease-dependent Invasive Phenotypes

1997 • 52 citations

Inhibition of MAP Kinase Kinase Causes Morphological Reversion and Dissociation between Soft Agar Growth and in Vivo Tumorigenesis in Angiosarcoma Cells

2000 • 46 citations

Differential cyclin-dependent kinase expression and activation in human colon cancer.

1999 • 19 citations