Characterization of Downstream Ras Signals That Induce Alternative Protease-dependent Invasive Phenotypes

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

The stress-activated protein kinase subfamily of c-Jun kinases

1994 • 2,616 citations

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

1994 • 1,999 citations

The small GTP-binding proteins Rac1 and Cdc42regulate the activity of the JNK/SAPK signaling pathway

1995 • 1,653 citations

Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

1995 • 1,499 citations

Transfer of purified herpes virus thymidine kinase gene to cultured mouse cells

1977 • 1,411 citations

Transformation of Mammalian Cells by Constitutively Active MAP Kinase Kinase

1994 • 1,370 citations

Biology and biochemistry of proteinases in tumor invasion

1993 • 1,264 citations

The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1

1988 • 1,256 citations

Differential Activation of ERK and JNK Mitogen-Activated Protein Kinases by Raf-1 and MEKK

1994 • 1,092 citations

Physiological consequences of loss of plasminogen activator gene function in mice

1994 • 1,051 citations

Solubilization and Purification of Enzymatically Active Glutathione S-Transferase (pGEX) Fusion Proteins

1993 • 891 citations

The Ets family of transcription factors

1993 • 848 citations

The activities of two Ets-related transcription factors required for drosophila eye development are modulated by the Ras/MAPK pathway

1994 • 690 citations

Endogenous Activation of Latent Collagenase by Rheumatoid Synovial Cells

1977 • 686 citations

Multiple ras functions can contribute to mammalian cell transformation

1995 • 658 citations

Cdc42 and PAK-mediated Signaling Leads to Jun Kinase and p38 Mitogen-activated Protein Kinase Activation

1995 • 639 citations

Regulation and properties of extracellular signal-regulated protein kinases 1 and 2 in vitro.

1993 • 503 citations

The collagenase gene promoter contains a TPA and oncogene-responsive unit encompassing the PEA3 and AP-1 binding sites.

1990 • 450 citations

Urokinase and urokinase receptor: A paracrine/autocrine system regulating cell migration and invasiveness

1993 • 402 citations

Microtubule‐associated‐protein (MAP) kinase activated by nerve growth factor and epidermal growth factor in PC12 cells

1990 • 386 citations

The c-Ets oncoprotein activates the stromelysin promoter through the same elements as several non-nuclear oncoproteins.

1991 • 380 citations

The Ras signal transduction pathway

1994 • 345 citations

Identification of the major phosphorylation sites of the Raf-1 kinase

1993 • 337 citations

Signal transduction within the nucleus by mitogen-activated protein kinase.

1992 • 323 citations

Ras target proteins in eukaryotic cells

1995 • 316 citations

SPARC, a secreted protein associated with morphogenesis and tissue remodeling, induces expression of metalloproteinases in fibroblasts through a novel extracellular matrix-dependent pathway.

1993 • 274 citations

Mechanisms of placental invasion of the uterus and their control

1992 • 242 citations

Mitogen-activated protein kinase/extracellular signal-regulated protein kinase activation by oncogenes, serum, and 12-O-tetradecanoylphorbol-13-acetate requires Raf and is necessary for transformation.

1994 • 237 citations

Suppression of oncogene-induced transformation by a deletion mutant of c-jun.

1993 • 227 citations

A requirement for extracellular signal-regulated kinase (ERK) function in the activation of AP-1 by Ha-Ras, phorbol 12-myristate 13-acetate, and serum.

1994 • 214 citations

Expression of cathepsin L in human tumors.

1991 • 208 citations

Extracellular Matrix‐Degrading Proteinases in the Nervous System

1994 • 208 citations

Mechanism of action of a dominant-negative mutant of c-Jun.

1994 • 207 citations

Mitogen-activated Protein Kinase Pathway and AP-1 Are Activated during cAMP-induced Melanogenesis in B-16 Melanoma Cells

1995 • 200 citations

Transformation suppressor activity of a Jun transcription factor lacking its activation domain

1991 • 190 citations

Oncogenic Ras activates c-Jun via a separate pathway from the activation of extracellular signal-regulated kinases.

1994 • 185 citations

Plasminogen activator dependent pathways inthe dissemination of human tumor cells in the chick embryo

1988 • 181 citations

Essential AP-1 and PEA3 binding elements in the human urokinase enhancer display cell type-specific activity.

1991 • 168 citations

Activation of human breast carcinoma collagenase through plasminogen activator

1980 • 160 citations

Mechanism of action of angiostatic steroids: Suppression of plasminogen activator activity via stimulation of plasminogen activator inhibitor synthesis

1993 • 144 citations

Transcription factor PEA3 participates in the induction of urokinase plasminogen activator transcription in murine keratinocytes stimulated with epidermal growth factor or phorbol-ester

1990 • 143 citations

Participation of cathepsin L on bone resorption

1993 • 130 citations

Jun is phosphorylated by several protein kinases at the same sites that are modified in serum-stimulated fibroblasts.

1992 • 123 citations

Expression of Human Recombinant Plasminogen Activators Enhances Invasion and Experimental Metastasis of H-ras-Transformed NIH 3T3 Cells

1989 • 120 citations

Heterodimerization of c-Jun with ATF-2 and c-Fos is required for positive and negative regulation of the human urokinase enhancer.

1995 • 119 citations

Experimental metastasis in nude mice of NIH 3T3 cells containing various ras genes.

1986 • 119 citations

Ovulation efficiency is reduced in mice that lack plasminogen activator gene function: functional redundancy among physiological plasminogen activators.

1995 • 116 citations

An upstream enhancer and a negative element in the 5' flanking region of the human urokinase plasminogen activator gene

1988 • 112 citations

“In vitro” Study of Basement Membrane Degradation by the Cysteine Proteinases, Cathepsins B, B-Like and L. Digestion of Collagen IV, Laminin, Fibronectin, and Release of Gelatinase Activities front Basement Membrane Fibronectin

1993 • 108 citations

Relationship between secreted urokinase plasminogen activator activity and metastatic potential in murine B16 cells transfected with human urokinase sense and antisense genes.

1990 • 99 citations

Transforming growth factor‐β1 stimulates macrophage urokinase expression and release of matrix‐bound basic fibroblast growth factor

1993 • 97 citations

[24] Biological assays for cellular transformation

1994 • 95 citations

Signaling through transforming G protein-coupled receptors in NIH 3T3 cells involves c-Raf activation. Evidence for a protein kinase C-independent pathway.

1994 • 88 citations

Elucidation of a signaling pathway induced by FGF-2 leading to uPA gene expression in NIH 3T3 fibroblasts.

1995 • 82 citations

Involvement of a Mitogen-activated Protein Kinase Signaling Pathway in the Regulation of Urokinase Promoter Activity by c-Ha-ras

1995 • 72 citations

Reversion of Ras transformed cells by Ets transdominant mutants.

1994 • 69 citations

Mature Cathepsin L Is Substantially Active in the Ionic Milieu of the Extracellular Medium

1995 • 62 citations

The murine urokinase-type plasminogen activator gene

1987 • 54 citations

[35] Methods for analyzing c-Jun kinase

1995 • 52 citations

ERM, a PEA3 Subfamily of Ets Transcription Factors, Can Cooperate with c-Jun

1995 • 52 citations

Multi‐step processing of procathepsin L in vitro

1994 • 49 citations

Secretion of a latent, acid activatable cathepsin L precursor by human non- small cell lung cancer cell lines

1995 • 44 citations

Quantitative analysis of mutually competitive binding of human Raf-1 and yeast adenylyl cyclase to Ras proteins.

1994 • 44 citations

Okadaic acid-dependent induction of the urokinase-type plasminogen activator gene associated with stabilization and autoregulation of c-Jun.

1994 • 35 citations

Fibroblasts transformed by different ras oncogenes show dissimilar patterns of protease gene expression and regulation.

1992 • 25 citations

Plasminogen activator activity and fertilizing ability of human spermatozoa

1993 • 14 citations

Tumorigenic and metastatic properties of two ras-oncogene transfected rat fibrosarcoma cell lines defective in c-jun.

1994 • 12 citations

[28] Mitogen-activated protein kinase activation by scrape loading of p2lras

1995 • 12 citations

Purification and characterization of collagenolytic property of renal cathepsin L from arthritic rat

1992 • 9 citations

Carcinological fauna of Japan

1977 • 3 citations