Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumors

ras GENES

1987 • 3,818 citations

The MAPK signaling cascade

1995 • 3,300 citations

Protein kinases and phosphatases: The Yin and Yang of protein phosphorylation and signaling

1995 • 2,907 citations

Protein modules and signalling networks

1995 • 2,447 citations

The mitogen-activated protein kinase signal transduction pathway

1993 • 2,174 citations

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

1994 • 1,999 citations

ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF

1991 • 1,901 citations

How MAP Kinases Are Regulated

1995 • 1,742 citations

Autocrine Secretion and Malignant Transformation of Cells

1980 • 1,370 citations

Transformation of Mammalian Cells by Constitutively Active MAP Kinase Kinase

1994 • 1,370 citations

MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo

1993 • 1,169 citations

The MAP kinase cascade is essential for diverse signal transduction pathways

1993 • 1,091 citations

Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II

1988 • 1,032 citations

The ras gene family and human carcinogenesis

1988 • 786 citations

Raf meets Ras: completing the framework of a signal transduction pathway

1994 • 591 citations

The ins and outs of Raf kinases

1994 • 537 citations

Oncoprotein Networks

1997 • 532 citations

Characterization of 21 newly established esophageal cancer cell lines

1992 • 490 citations

Three human transforming genes are related to the viral ras oncogenes.

1983 • 379 citations

The Tumor Suppressor Protein p16INK4a

1997 • 332 citations

Control of MAP kinase activation by the mitogen-induced threonine/tyrosine phosphatase PAC1

1994 • 331 citations

Signal integration at the level of protein kinases, protein phosphatases and their substrates

1992 • 314 citations

Diverse Mitogenic Agents Induce the Phosphorylation of Two Related 42,000-Dalton Proteins on Tyrosine in Quiescent Chick Cells

1984 • 159 citations

Enhanced expression of c-myc and epidermal growth factor receptor (C-erbB-1) genes in primary human renal cancer.

1988 • 126 citations

Diverse mitogenic agents induce rapid phosphorylation of a common set of cellular proteins at tyrosine in quiescent mammalian cells.

1985 • 125 citations

The phorbol ester-dependent activator of the mitogen-activated protein kinase p42mapk is a kinase with specificity for the threonine and tyrosine regulatory sites.

1992 • 111 citations

Cloning of genes developmentally regulated during plant embryogenesis

1987 • 105 citations

Characterization of the Bone Morphogenetic Protein-2 as a Neurotrophic Factor

1996 • 100 citations

Activation of the 41/43 kDa mitogen-activated protein kinase signaling pathway is required for hepatocyte growth factor-induced cell scattering

1998 • 95 citations

Distribution and Characterization of Specific Cellular Binding Proteins for Bone Morphogenetic Protein-2

1995 • 89 citations

Germ-line mutations of thep16INK4(MTS1) gene occur in a subset of patients with hepatocellular carcinoma

1997 • 85 citations

Cell Type-specific Modulation of Cell Growth by Transforming Growth Factor β1 Does Not Correlate with Mitogen-activated Protein Kinase Activation

1995 • 43 citations

Competitive NMDA receptor antagonists raise electrically kindled generalized seizure thresholds

1992 • 34 citations

Mitogen-induced tyrosine-phosphorylated 41- and 43-kDa proteins are family members of extracellular signal-regulated kinases/microtubule-associated protein 2 kinases.

1992 • 30 citations

Mutation analysis of the coding sequences of MEK-1 and MEK-2 genes in human lung cancer cell lines

1997 • 26 citations

Up‐regulation of p27^Kip1 Correlates Inversely with Anchorage‐independent Growth of Human Cancer Cell Lines

1998 • 19 citations

Structure of the Activated c-raf-1 Gene from Human Stomach Cancer

1986 • 14 citations

Expression of Fas-estrogen receptor fusion protein induces cell death in pancreatic cancer cell lines

1997 • 9 citations