Enhanced Tumorigenicity and Invasion-Metastasis by Hepatocyte Growth Factor/Scatter Factor-Met Signalling in Human Cells Concomitant with Induction of the Urokinase Proteolysis Network

THE PREPARATION OF 131I-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITY

1963 • 10,322 citations

Matrix Metalloproteinases: A Review

1993 • 2,998 citations

Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter.

1982 • 2,753 citations

Tumor Cell Interactions with the Extracellular Matrix During Invasion and Metastasis

1993 • 1,523 citations

Scatter factor/hepatocyte growth factor is essential for liver development

1995 • 1,398 citations

Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth.

1992 • 1,345 citations

Scatter factor is a fibroblast-derived modulator of epithelial cell mobility

1987 • 1,333 citations

Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud

1995 • 1,278 citations

Identification of a fibroblast-derived epithelial morphogen as hepatocyte growth factor

1991 • 1,176 citations

Placental defect and embryonic lethality in mice lacking hepatocyte growth factor/scatter factor

1995 • 1,039 citations

Molecular cloning of a new transforming gene from a chemically transformed human cell line

1984 • 966 citations

Cell-Associated Plasminogen Activation: Regulation and Physiological Functions

1988 • 826 citations

Scatter factor/hepatocyte growth factor and its receptor, the c-met tyrosine kinase, can mediate a signal exchange between mesenchyme and epithelia during mouse development.

1993 • 707 citations

Scatter factor induces blood vessel formation in vivo.

1993 • 704 citations

Scatter factor: molecular characteristics and effect on the invasiveness of epithelial cells.

1990 • 695 citations

Extracellular proteolytic cleavage by urokinase is required for activation of hepatocyte growth factor/scatter factor.

1992 • 571 citations

Sequence of MET protooncogene cDNA has features characteristic of the tyrosine kinase family of growth-factor receptors.

1987 • 567 citations

An endothelial cell receptor for plasminogen/tissue plasminogen activator. I. Identity with annexin II.

1994 • 509 citations

Urokinase and urokinase receptor: A paracrine/autocrine system regulating cell migration and invasiveness

1993 • 402 citations

Amiloride selectively inhibits the urokinase‐type plasminogen activator

1987 • 378 citations

Invasiveness and metastasis of NIH 3T3 cells induced by Met-hepatocyte growth factor/scatter factor autocrine stimulation.

1994 • 363 citations

Autocrine saturation of pro-urokinase receptors on human A431 cells

1986 • 361 citations

An endothelial cell receptor for plasminogen/tissue plasminogen activator (t-PA). II. Annexin II-mediated enhancement of t-PA-dependent plasminogen activation.

1994 • 341 citations

Hepatocyte growth factor: molecular structure, roles in liver regeneration, and other biological functions.

1992 • 327 citations

Tumorigenicity of the met proto-oncogene and the gene for hepatocyte growth factor.

1992 • 316 citations

Roles of hepatocyte growth factor/scatter factor and the met receptor in the early development of the metanephros.

1995 • 309 citations

Hepatocyte growth factor/scatter factor and its receptor, the c-met proto-oncogene product

1993 • 281 citations

The Met/HGF receptor is over-expressed in human osteosarcomas and is activated by either a paracrine or an autocrine circuit.

1995 • 281 citations

The met Proto-Oncogene Receptor and Lumen Formation

1992 • 246 citations

Plasminogen activator inhibitor from human fibrosarcoma cells binds urokinase-type plasminogen activator, but not its proenzyme.

1986 • 232 citations

Identification of a Competitive HGF Antagonist Encoded by an Alternative Transcript

1991 • 224 citations

A functional domain in the heavy chain of scatter factor/hepatocyte growth factor binds the c-Met receptor and induces cell dissociation but not mitogenesis.

1992 • 222 citations

Hepatocyte growth factor increases urokinase-type plasminogen activator (u-PA) and u-PA receptor expression in Madin-Darby canine kidney epithelial cells.

1992 • 219 citations

The Met Proto-Oncogene Mesenchymal to Epithelial Cell Conversion

1994 • 215 citations

Plasminogen

1992 • 214 citations

Hepatocyte growth factor/scatter factor effects on epithelia. Regulation of intercellular junctions in transformed and nontransformed cell lines, basolateral polarization of c-met receptor in transformed and natural intestinal epithelia, and induction of rapid wound repair in a transformed model epithelium.

1994 • 209 citations

Involvement of Hepatocyte Growth Factor in Kidney Development

1994 • 200 citations

Urokinase‐type plasminogen activator mediates basic fibroblast growth factor‐induced bovine endothelial cell migration independent of its proteolytic activity

1992 • 183 citations

Requirement for receptor‐bound urokinase in plasmin‐dependent cellular conversion of latent TGF‐β to TGF‐β

1994 • 176 citations

Creation of an hepatocyte growth factor/scatter factor autocrine loop in carcinoma cells induces invasive properties associated with increased tumorigenicity.

1994 • 171 citations

The Urokinase Receptor: Involvement in Cell Surface Proteolysis and Cancer Invasion

1992 • 165 citations

Transfer of motogenic and invasive response to scatter factor/hepatocyte growth factor by transfection of human MET protooncogene.

1993 • 159 citations

Met expression and sarcoma tumorigenicity.

1993 • 144 citations

Scatter factor and hepatocyte growth factor: activities, properties, and mechanism.

1992 • 136 citations

New Method for Detecting Cellular Transforming Genes

1982 • 131 citations

Roles of HGF as a pleiotropic factor in organ regeneration.

1993 • 131 citations

A role for HGF/SF in neural induction and its expression in Hensen’s node during gastrulation

1995 • 106 citations

Tumorigenesis induced by coexpression of human hepatocyte growth factor and the human met protooncogene leads to high levels of expression of the ligand and receptor.

1993 • 90 citations

Scatter factor modulates the metastatic phenotype of the EMT6 mouse mammary tumor

1994 • 88 citations

Urokinase-Type and Tissue-Type Plasminogen Activators as Growth Factors of Human Fibroblasts

1994 • 78 citations

Hepatocyte growth factor/scatter factor (HGF/SF), the c-met receptor and the behaviour of epithelial cells.

1993 • 66 citations

Structural polypeptides of mammalian type C RNA viruses. Isolation and immunologic characterization of a low molecular weight polypeptide, p10.

1976 • 64 citations

Urokinase and urokinase receptor: a paracrinelautocrine system regulating cell migration and invasiveness

1993 • 56 citations

Met proto-oncogene product is overexpressed in tumors of p53-deficient mice and tumors of Li-Fraumeni patients.

1995 • 54 citations

Bimodal relationship between invasion of the amniotic membrane and plasminogen activator activity

1990 • 45 citations

The presence of scatter factor in patients with metastatic spread to the pleura

1992 • 34 citations

Tumor cytotoxic activity of HGF-SF.

1993 • 13 citations