Anthrax toxin lethal factor contains a zinc metalloprotease consensus sequence which is required for lethal toxin activity

Basic local alignment search tool

1990 • 87,358 citations

Tetanus and botulinum-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevin

1992 • 1,792 citations

Zinc coordination, function, and structure of zinc enzymes and other proteins

1990 • 1,731 citations

Gene Splicing by Overlap Extension: Tailor-Made Genes Using the Polymerase Chain Reaction

2013 • 1,306 citations

Anthrax toxin edema factor: a bacterial adenylate cyclase that increases cyclic AMP concentrations of eukaryotic cells.

1982 • 929 citations

Bestatin, an inhibitor of aminopeptidase B, produced by actinomycetes.

1976 • 706 citations

Macrophages are sensitive to anthrax lethal toxin through an acid-dependent process.

1986 • 586 citations

Sourcebook of bacterial protein toxins

1991 • 537 citations

Cellubrevin is a ubiquitous tetanus-toxin substrate homologous to a putative synaptic vesicle fusion protein

1993 • 504 citations

Bacterial toxins and cell membranes

1978 • 471 citations

Anthrax toxin protective antigen is activated by a cell surface protease with the sequence specificity and catalytic properties of furin.

1992 • 457 citations

A unique signature identifies a family of zinc‐dependent metallopeptidases

1989 • 453 citations

Active-site zinc ligands and activated H2O of zinc enzymes.

1990 • 432 citations

Advances in Cyclic Nucleotide and Protein Phosphorylation Research

1975 • 373 citations

Contribution of individual toxin components to virulence of Bacillus anthracis

1991 • 363 citations

The PROSITE dictionary of sites and patterns in proteins, its current status

1993 • 353 citations

The Conformation of Thermolysin

1974 • 332 citations

Botulinum neurotoxin serotype F is a zinc endopeptidase specific for VAMP/synaptobrevin.

1993 • 300 citations

Tetanus toxin is a zinc protein and its inhibition of neurotransmitter release and protease activity depend on zinc.

1992 • 299 citations

Botulinum neurotoxin serotype F is a zinc endopeptidase specific for VAMP/synaptobrevin

1993 • 283 citations

Bacterial extracellular zinc-containing metalloproteases

1993 • 264 citations

Botulinum neurotoxins are zinc proteins.

1992 • 249 citations

Botulinum neurotoxins are zinc proteins.

1992 • 243 citations

Bacterial Protein Toxins

1985 • 237 citations

Molecular characterization and nucleotide sequence of the Pseudomonas aeruginosa elastase structural gene

1988 • 232 citations

Three-dimensional structure of the elastase of Pseudomonas aeruginosa at 1.5-A resolution.

1991 • 201 citations

Three-dimensional structure of the elastase of Pseudomonas aeruginosa at 1.5-A resolution.

1991 • 177 citations

Residues 1-254 of anthrax toxin lethal factor are sufficient to cause cellular uptake of fused polypeptides.

1993 • 172 citations

The complete nucleotide sequence of tetanus toxin

1986 • 159 citations

Characterization of macrophage sensitivity and resistance to anthrax lethal toxin

1993 • 153 citations

Immunoelectrophoretic analysis, toxicity, and kinetics of in vitro production of the protective antigen and lethal factor components of Bacillus anthracis toxin

1984 • 144 citations

Cloning and expression of the Bacillus anthracis protective antigen gene in Bacillus subtilis

1986 • 133 citations

Molecular cloning, sequencing, and identification of a metalloprotease gene from Listeria monocytogenes that is species specific and physically linked to the listeriolysin gene

1991 • 132 citations

Fusions of anthrax toxin lethal factor to the ADP-ribosylation domain of Pseudomonas exotoxin A are potent cytotoxins which are translocated to the cytosol of mammalian cells.

1992 • 127 citations

Nucleotide sequence and analysis of the lethal factor gene (lef) from Bacillus anthracis

1989 • 125 citations

Crystal structure of neutral protease from Bacillus cereus refined at 3.0A˚resolution and comparison with the homologous but more thermostable enzyme thermolysin

1988 • 117 citations

Amino Acid Sequence Deduced from a Rat Kidney cDNA Suggests It Encodes the Zn-Peptidase Aminopeptidase N

1989 • 116 citations

Nucleotide sequence of the gene encodingClostridium botulinumneurotoxin type D

1990 • 115 citations

Construction and characterization of a protective antigen‐deficient Bacillus anthracis strain

1990 • 114 citations

The chemical basis of the virulence of Bacillus anthracis. V. The specific toxin produced by B. Anthracis in vivo.

1955 • 107 citations

Molecular cloning and expression in Escherichia coli of the lethal factor gene of Bacillus anthracis

1986 • 96 citations

Molecular Mechanisms of Bacterial Virulence

1994 • 93 citations

Functional mapping of anthrax toxin lethal factor by in-frame insertion mutagenesis.

1991 • 83 citations

The Three Factors of Anthrax Toxin: their Immunogenicity and Lack of Demonstrable Enzymic Activity

1963 • 82 citations

Cloning and Nucleotide Sequence of the Highly Thermostable Neutral Protease Gene from Bacillus stearothermophilus

1988 • 82 citations

THE CHEMICAL BASIS OF THE VIRULENCE OF BACILLUS ANTHRACIS. IX. ITS AGGRESSINS AND THEIR MODE OF ACTION.

1963 • 73 citations

Identification and partial characterization of a low affinity metal-binding site in the light chain of tetanus toxin.

1992 • 67 citations

Virulence and Immunogenicity in Experimental Animals of Bacillus anthracis Strains Harbouring or Lacking 110 MDa and 60 MDa Plasmids

1986 • 59 citations

Complete nucleotide sequence of the structural gene for alkaline proteinase from Pseudomonas aeruginosa IFO 3455

1990 • 58 citations

The role of the pro-sequence in the processing and secretion of the thermolysin-like neutral protease from Bacillus cereus

1992 • 57 citations

Purification of anthrax-toxin components by high-performance anion-exchange, gel-filtration and hydrophobic-interaction chromatography

1988 • 52 citations

Quantitative Assay for Crude Anthrax Toxins

1965 • 47 citations

Purification of the Third Factor of Anthrax Toxin

1962 • 47 citations

The metalloprotease gene ofSerratia marcescens strain SM6

1990 • 46 citations

Production in vitro of the Toxin of Bacillus anthracis Previously Recognized in vivo

1958 • 43 citations

The role of proline 345 in diphtheria toxin translocation.

1993 • 37 citations

Transformation of vegetative cells of Bacillus anthracis with plasmid DNA

1990 • 34 citations