Ras Signals to the Cell Cycle Machinery via Multiple Pathways To Induce Anchorage-Independent Growth

ras oncogenes in human cancer: a review.

1989 • 5,116 citations

Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation

1995 • 4,589 citations

ras GENES

1987 • 3,818 citations

Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

1990 • 2,129 citations

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

1994 • 1,999 citations

Proteins regulating Ras and its relatives

1993 • 1,930 citations

Cyclin D1 is a nuclear protein required for cell cycle progression in G1.

1993 • 1,605 citations

Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

1995 • 1,499 citations

New functional activities for the p21 family of CDK inhibitors.

1997 • 1,414 citations

Biochemical transfer of single-copy eucaryotic genes using total cellular DNA as donor

1978 • 1,284 citations

Cyclin D1 Expression Is Regulated Positively by the p42/p44 and Negatively by the p38/HOG Pathway

1996 • 1,203 citations

Human Cyclin E, a Nuclear Protein Essential for the G₁-to-S Phase Transition

1995 • 1,132 citations

Role of Phosphoinositide 3-OH Kinase in Cell Transformation and Control of the Actin Cytoskeleton by Ras

1997 • 1,064 citations

Overexpression of mouse D-type cyclins accelerates G1 phase in rodent fibroblasts.

1993 • 1,057 citations

Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway

1997 • 1,050 citations

c-Myc transactivation of LDH-A : Implications for tumor metabolism and growth

1997 • 1,015 citations

Acceleration of the G₁/S Phase Transition by Expression of Cyclins Dl and E with an Inducible System

1994 • 986 citations

An essential role for Rac in Ras transformation

1995 • 895 citations

Cyclin a is required for the onset of DNA replication in mammalian fibroblasts

1991 • 884 citations

Tumorigenicity of virus-transformed cells in nude mice is correlated specifically with anchorage independent growth in vitro.

1975 • 747 citations

Activation of Rac1, RhoA, and Mitogen-Activated Protein Kinases Is Required for Ras Transformation

1995 • 683 citations

Acceleration of the G1/S phase transition by expression of cyclins D1 and E with an inducible system.

1994 • 659 citations

Multiple ras functions can contribute to mammalian cell transformation

1995 • 658 citations

Raf-1 protein kinase is required for growth of induced NIH/3T3 cells

1991 • 489 citations

Adhesion-dependent cell cycle progression linked to the expression of cyclin D1, activation of cyclin E-cdk2, and phosphorylation of the retinoblastoma protein.

1996 • 453 citations

Ras effectors

1996 • 445 citations

Transformation of Chicken Cells by the Gene Encoding the Catalytic Subunit of PI 3-Kinase

1997 • 414 citations

A Link Between Cyclin A Expression and Adhesion-Dependent Cell Cycle Progression

1993 • 399 citations

Stimulation of Membrane Ruffling and MAP Kinase Activation by Distinct Effectors of RAS

1996 • 377 citations

Dependence of Cyclin E-CDK2 Kinase Activity on Cell Anchorage

1996 • 371 citations

Cell cycle expression and p53 regulation of the cyclin-dependent kinase inhibitor p21.

1994 • 363 citations

Oncogenic Ras Activation of Raf/Mitogen-Activated Protein Kinase-Independent Pathways Is Sufficient To Cause Tumorigenic Transformation

1996 • 350 citations

Ral-GTPases mediate a distinct downstream signaling pathway from Ras that facilitates cellular transformation.

1996 • 335 citations

Cdc42 Regulates Anchorage-Independent Growth and Is Necessary for Ras Transformation

1997 • 312 citations

Signal transduction from multiple Ras effectors

1997 • 308 citations

Ras Transformation Results in an Elevated Level of Cyclin D1 and Acceleration of G₁ Progression in NIH 3T3 cells

1995 • 276 citations

Cyclin A-Associated Kinase Activity Is Rate Limiting for Entrance into S Phase and Is Negatively Regulated in G₁ by p27^Kip1

1995 • 252 citations

A Role for the Ral Guanine Nucleotide Dissociation Stimulator in Mediating Ras-induced Transformation

1996 • 245 citations

Definition of the human raf amino-terminal regulatory region by deletion mutagenesis.

1989 • 240 citations

Anchorage-Dependent Transcription of the Cyclin A Gene

1996 • 136 citations

p27^KIP1 Blocks Cyclin E-Dependent Transactivation of Cyclin A Gene Expression

1997 • 119 citations

Protein binding and signaling properties of RIN1 suggest a unique effector function

1997 • 114 citations

Ras Induces Anchorage-Independent Growth by Subverting Multiple Adhesion-Regulated Cell Cycle Events

1996 • 96 citations

p21H-ras-induced morphological transformation and increases in c-myc expression are independent of functional protein kinase C.

1989 • 85 citations

Ice Rhythms—Core Reveals a Plethora of Climate Cycles

1996 • 79 citations

Synergistic activation of c-fos promoter activity by Raf and Ral GDP dissociation stimulator

1997 • 63 citations

Cells Arrested in G1 by the v-Abl Tyrosine Kinase Do Not Express Cyclin A Despite the Hyperphosphorylation of RB

1996 • 42 citations

Adhesion-Dependent Control of Cyclin E/cdk2 Activity and Cell Cycle Progression in Normal Cells but Not inHa-rasTransformed NRK Cells

1996 • 26 citations

Extracellular ATP Induces Anchorage-independent Expression of Cyclin A and Rescues the Transformed Phenotype of a Ras-resistant Mutant Cell Line

1997 • 24 citations

Interaction of Activated Ras with Raf-1 Alone May Be Sufficient for Transformation of rat2 Cells

1997 • 23 citations

Novel revertants of H-ras oncogene-transformed R6-PKC3 cells.

1992 • 18 citations

The RB/p107/p130 phosphorylation pathway is not inhibited in rapamycin-induced G1-prolongation of NIH3T3 cells.

1996 • 17 citations

Dissociation ofras oncogene-induced gene expression and anchorage-independent growth in a series of somatic cell mutants

1996 • 4 citations