The interactions of dendritic cells with antigen-specific, regulatory T cells that suppress autoimmunity

Innate Immune Recognition

2002 • 8,157 citations

Control of Regulatory T Cell Development by the Transcription Factor Foxp3

2003 • 7,902 citations

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

2003 • 7,470 citations

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

2010 • 5,969 citations

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

1995 • 5,124 citations

A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis

1997 • 3,625 citations

N<scp>aturally</scp>A<scp>rising</scp>CD4⁺R<scp>egulatory</scp>T C<scp>ells for</scp>I<scp>mmunologic</scp>S<scp>elf</scp>-T<scp>olerance and</scp>N<scp>egative</scp>C<scp>ontrol of</scp>I<scp>mmune</scp>R<scp>esponses</scp>

2003 • 3,323 citations

The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

2001 • 3,260 citations

Tolerogenic Dendritic Cells

2003 • 3,131 citations

Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self

2005 • 2,667 citations

CD4+CD25+ Immunoregulatory T Cells Suppress Polyclonal T Cell Activation In Vitro by Inhibiting Interleukin 2 Production

1998 • 2,658 citations

The Effect of Infections on Susceptibility to Autoimmune and Allergic Diseases

2002 • 2,592 citations

Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse

2001 • 2,503 citations

CD4+CD25+ suppressor T cells: more questions than answers

2002 • 2,202 citations

B7/CD28 Costimulation Is Essential for the Homeostasis of the CD4+CD25+ Immunoregulatory T Cells that Control Autoimmune Diabetes

2000 • 2,090 citations

Toll Pathway-Dependent Blockade of CD4 ⁺ CD25 ⁺ T Cell-Mediated Suppression by Dendritic Cells

2003 • 2,023 citations

Dendritic Cells Induce Peripheral T Cell Unresponsiveness under Steady State Conditions in Vivo

2001 • 1,845 citations

Loss of Functional Suppression by CD4+CD25+ Regulatory T Cells in Patients with Multiple Sclerosis

2004 • 1,835 citations

X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy

2001 • 1,831 citations

Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene

1993 • 1,762 citations

CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity

2002 • 1,733 citations

Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide

2001 • 1,659 citations

Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state.

1998 • 1,579 citations

Immature, semi-mature and fully mature dendritic cells: which signals induce tolerance or immunity?

2002 • 1,343 citations

Efficient Targeting of Protein Antigen to the Dendritic Cell Receptor DEC-205 in the Steady State Leads to Antigen Presentation on Major Histocompatibility Complex Class I Products and Peripheral CD8+ T Cell Tolerance

2002 • 1,296 citations

Regulatory T Cells in Autoimmmunity

2000 • 1,267 citations

Inducing and expanding regulatory T cell populations by foreign antigen

2005 • 1,245 citations

Compromised Function of Regulatory T Cells in Rheumatoid Arthritis and Reversal by Anti-TNFα Therapy

2004 • 1,242 citations

In Vitro–expanded Antigen-specific Regulatory T Cells Suppress Autoimmune Diabetes

2004 • 1,192 citations

Homeostatic maintenance of natural Foxp3+ CD25+ CD4+ regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization

2005 • 1,189 citations

THE NOD MOUSE: A Model of Immune Dysregulation

2004 • 1,080 citations

Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment

1995 • 1,079 citations

Natural regulatory T cells in infectious disease

2005 • 1,035 citations

Cutting Edge: Cure of Colitis by CD4+CD25+ Regulatory T Cells

2003 • 933 citations

Direct Expansion of Functional CD25+ CD4+ Regulatory T Cells by Antigen-processing Dendritic Cells

2003 • 893 citations

Deregulated T Cell Activation and Autoimmunity in Mice Lacking Interleukin-2 Receptor β

1995 • 868 citations

Tolerance, not immunity, crucially depends on IL-2

2004 • 826 citations

Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cells

2004 • 805 citations

Interleukin-10 induces a long-term antigen-specific anergic state in human CD4+ T cells.

1996 • 788 citations

CD4 Regulatory T Cells Prevent Lethal Autoimmunity in IL-2Rβ-Deficient Mice

2002 • 783 citations

Hassall's corpuscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymus

2005 • 743 citations

CD25+ CD4+ T Cells, Expanded with Dendritic Cells Presenting a Single Autoantigenic Peptide, Suppress Autoimmune Diabetes

2004 • 741 citations

In Vivo Instruction of Suppressor Commitment in Naive T Cells

2004 • 726 citations

Tumor cells convert immature myeloid dendritic cells into TGF-β–secreting cells inducing CD4+CD25+ regulatory T cell proliferation

2005 • 716 citations

Following a diabetogenic T cell from genesis through pathogenesis

1993 • 708 citations

Activation of Natural Killer T Cells by α-Galactosylceramide Rapidly Induces the Full Maturation of Dendritic Cells In Vivo and Thereby Acts as an Adjuvant for Combined CD4 and CD8 T Cell Immunity to a Coadministered Protein

2003 • 698 citations

Other Functions, Other Genes

1999 • 686 citations

Cutting Edge: CD28 Controls Peripheral Homeostasis of CD4+CD25+ Regulatory T Cells

2003 • 674 citations

Efficient Presentation of Phagocytosed Cellular Fragments on the Major Histocompatibility Complex Class II Products of Dendritic Cells

1998 • 649 citations

The CD8+ Dendritic Cell Subset Selectively Endocytoses Dying Cells in Culture and In Vivo

2002 • 641 citations

Antigen-dependent Proliferation of CD4+ CD25+ Regulatory T Cells In Vivo

2003 • 600 citations

CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2

2005 • 591 citations

Cutting Edge: IL-2 Is Critically Required for the In Vitro Activation of CD4+CD25+ T Cell Suppressor Function

2004 • 572 citations

Transforming Growth Factor-β Production and Myeloid Cells Are an Effector Mechanism through Which CD1d-restricted T Cells Block Cytotoxic T Lymphocyte–mediated Tumor Immunosurveillance

2003 • 539 citations

Resting dendritic cells induce peripheral CD8+ T cell tolerance through PD-1 and CTLA-4

2005 • 532 citations

Continuous Activation of Autoreactive CD4+ CD25+ Regulatory T Cells in the Steady State

2003 • 523 citations

Control of intestinal inflammation by regulatory T cells

2001 • 496 citations

Essential role for CD103 in the T cell–mediated regulation of experimental colitis

2005 • 474 citations

The CD8α+ Dendritic Cell Is Responsible for Inducing Peripheral Self-Tolerance to Tissue-associated Antigens

2002 • 468 citations

Immune Tolerance After Delivery of Dying Cells to Dendritic Cells In Situ

2002 • 466 citations

CD4+CD25+ T Regulatory Cells Dependent on ICOS Promote Regulation of Effector Cells in the Prediabetic Lesion

2004 • 443 citations

Functional defect of regulatory CD4+CD25+ T cells in the thymus of patients with autoimmune myasthenia gravis

2004 • 420 citations

Induction of CD4+/CD25+ regulatory T cells by targeting of antigens to immature dendritic cells

2003 • 392 citations

In vivodynamics of antigen-specific regulatory T cells not predicted from behaviorin vitro

2003 • 384 citations

The Subpopulation of CD4+CD25+ Splenocytes That Delays Adoptive Transfer of Diabetes Expresses L-Selectin and High Levels of CCR7

2002 • 383 citations

Physiological β Cell Death Triggers Priming of Self-reactive T Cells by Dendritic Cells in a Type-1 Diabetes Model

2003 • 345 citations

Pancreatic Lymph Node-Derived CD4+CD25+ Treg Cells

2002 • 312 citations

Inducible Transgenic Mice Reveal Resting Dendritic Cells as Potent Inducers of CD8+ T Cell Tolerance

2003 • 309 citations

Effect of tumor necrosis factor alpha on insulin-dependent diabetes mellitus in NOD mice. I. The early development of autoimmunity and the diabetogenic process.

1994 • 300 citations

Peripheral Autoantigen Induces Regulatory T Cells that Prevent Autoimmunity

1999 • 284 citations

Specificity requirements for selection and effector functions of CD25⁺4⁺regulatory T cells in anti-myelin basic protein T cell receptor transgenic mice

2002 • 267 citations

Prevention of Type I Diabetes in NOD Mice by Adjuvant Immunotherapy

1990 • 264 citations

Expansion of Functional Endogenous Antigen-Specific CD4+CD25+ Regulatory T Cells from Nonobese Diabetic Mice

2005 • 254 citations

Generation of CD4+CD25+ Regulatory T Cells from Autoreactive T Cells Simultaneously with Their Negative Selection in the Thymus and from Nonautoreactive T Cells by Endogenous TCR Expression

2002 • 253 citations

Tumor necrosis factor-α regulation of CD4⁺C25⁺T cell levels in NOD mice

2002 • 252 citations

Dynamics of Pathogenic and Suppressor T Cells in Autoimmune Diabetes Development

2003 • 243 citations

Essential role for interleukin-2 for CD4+CD25+ T regulatory cell development during the neonatal period

2005 • 237 citations

CD4+ CD25+ Regulatory T Cells Control T Helper Cell Type 1 Responses to Foreign Antigens Induced by Mature Dendritic Cells In Vivo

2003 • 230 citations

Regulatory T cells in autoimmunity

2007 • 228 citations

Control of Foxp3+ CD25+CD4+ regulatory cell activation and function by dendritic cells

2004 • 226 citations

Immunological Unresponsiveness Characterized by Increased Expression of CD5 on Peripheral T Cells Induced by Dendritic Cells In Vivo

2004 • 222 citations

Identification of MHC Class II-Restricted Peptide Ligands, Including a Glutamic Acid Decarboxylase 65 Sequence, that Stimulate Diabetogenic T Cells from Transgenic BDC2.5 Nonobese Diabetic Mice

2001 • 213 citations

Single cell analysis shows decreasing FoxP3 and TGFβ1 coexpressing CD4+CD25+ regulatory T cells during autoimmune diabetes

2005 • 210 citations

Dendritic cells constitutively present self antigens in their immature state in vivo and regulate antigen presentation by controlling the rates of MHC class II synthesis and endocytosis

2003 • 203 citations

Dendritic cells are the principal cells in mouse spleen bearing immunogenic fragments of foreign proteins.

1990 • 193 citations

Effective expansion of alloantigen-specific Foxp3⁺CD25⁺CD4⁺regulatory T cells by dendritic cells during the mixed leukocyte reaction

2006 • 189 citations

Control of T cell hyperactivation in IL-2-deficient mice by CD4+CD25- and CD4+CD25+ T cells: evidence for two distinct regulatory mechanisms

2001 • 183 citations

Immunostimulation circumvents diabetes in NODLt mice

1989 • 182 citations

Continuous control of autoimmune disease by antigen-dependent polyclonal CD4+CD25+ regulatory T cells in the regional lymph node

2005 • 180 citations

A comprehensive guide to antibody and T‐cell responses in type 1 diabetes

2003 • 166 citations

Generalized Resistance to Thymic Deletion in the NOD Mouse

2004 • 157 citations

Defective maturation and function of antigen-presenting cells in type 1 diabetes

1995 • 147 citations

Failure to Censor Forbidden Clones of CD4 T Cells in Autoimmune Diabetes

2002 • 140 citations

The stages of type 1A diabetes: 2005

2005 • 127 citations

Specific T Regulatory Cells Display Broad Suppressive Functions against Experimental Allergic Encephalomyelitis upon Activation with Cognate Antigen

2005 • 125 citations

Early social mixing and childhood Type 1 diabetes mellitus: a case–control study in Yorkshire, UK

2000 • 120 citations

The role of TNF-α in the pathogenesis of type 1 diabetes in the nonobese diabetic mouse: Analysis of dendritic cell maturation

2005 • 103 citations

The Stages of Type 1A Diabetes

2005 • 96 citations

Effector and regulatory cells in autoimmune oophoritis elicited by neonatal thymectomy.

1991 • 96 citations

Unmasking immunosurveillance against a syngeneic colon cancer by elimination of CD4+ NKT regulatory cells and IL-13

2004 • 88 citations

Induction of Regulatory Properties in Dendritic Cells by Vα14 NKT Cells

2005 • 86 citations

Persistence of Physiological Self Antigen Is Required for the Regulation of Self Tolerance

2000 • 83 citations

BCG Vaccination Prevents Insulin-Dependent Diabetes Mellitus (IDDM) in NOD Mice after Disease Acceleration with Cyclophosphamide

1997 • 76 citations

Prevention of type I diabetes in NOD mice by adjuvant immunotherapy

1990 • 76 citations

Generalized Resistance to Thymic Deletion in the NOD MouseA Polygenic Trait Characterized by Defective Induction of Bim

2004 • 48 citations

Characterization of the Extracellular Matrix—Containing Giant Perivascular Spaces in the NOD Mouse Thymus

1993 • 46 citations

Cell‐intrinsic effects of non‐MHC NOD genes on dendritic cell generation in vivo

2002 • 43 citations

Regulatory T‐cell, endogenous antigen and neonatal environment in the prevention and induction of autoimmune disease

2001 • 39 citations

Disorganization of Thymic Medulla Precedes Evolution Towards Diabetes in Female NOD Mice

1999 • 28 citations

Genetic Control of Giant Perivascular Space Formation in the Thymus of NOD Mice

1996 • 26 citations

Intrinsic in vitro abnormalities in dendritic cell generation caused by non‐MHC non‐obese diabetic genes

2002 • 21 citations

Characterization of the extracellular matrix-containing giant perivascular spaces in the NOD mouse thymus

1993 • 20 citations

Genetic control of giant perivascular space formation in the thymus of NOD mice

1996 • 12 citations