Tumor necrosis factor-α regulation of CD4⁺C25⁺T cell levels in NOD mice

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

2010 • 5,969 citations

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

1995 • 5,124 citations

CD4+CD25+ Immunoregulatory T Cells Suppress Polyclonal T Cell Activation In Vitro by Inhibiting Interleukin 2 Production

1998 • 2,658 citations

Cytotoxic T Lymphocyte–Associated Antigen 4 Plays an Essential Role in the Function of Cd25+Cd4+ Regulatory Cells That Control Intestinal Inflammation

2000 • 2,211 citations

Immunologic Self-Tolerance Maintained by Cd25+Cd4+Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4

2000 • 2,207 citations

CTLA-4 can function as a negative regulator of T cell activation

1994 • 2,107 citations

B7/CD28 Costimulation Is Essential for the Homeostasis of the CD4+CD25+ Immunoregulatory T Cells that Control Autoimmune Diabetes

2000 • 2,090 citations

Regulatory T Cells

2000 • 1,827 citations

Stimulation of CD25+CD4+ regulatory T cells through GITR breaks immunological self-tolerance

2002 • 1,745 citations

CD4+CD25+ Immunoregulatory T Cells

2002 • 1,434 citations

CD4+CD25+ T Cells Inhibit Both the Induction and Effector Function of Autoreactive T Cells and Represent a Unique Lineage of Immunoregulatory Cells

1998 • 893 citations

Multiple immuno-regulatory defects in type-1 diabetes

2002 • 645 citations

Multiple immuno-regulatory defects in type-1 diabetes

2002 • 548 citations

Certified Professionals

2001 • 533 citations

Protein Expression and Functional Difference of Membrane-Bound and Soluble Receptor Activator of NF-κB Ligand: Modulation of the Expression by Osteotropic Factors and Cytokines

2000 • 491 citations

Generation and characterization of hamster monoclonal antibodies that neutralize murine tumor necrosis factors.

1989 • 385 citations

Prevention of diabetes in nonobese diabetic mice by tumor necrosis factor (TNF): similarities between TNF-alpha and interleukin 1.

1990 • 356 citations

Regulation of surface and intracellular expression of CTLA4 on mouse T cells.

1996 • 340 citations

Pancreatic Lymph Node-Derived CD4+CD25+ Treg Cells

2002 • 312 citations

Effect of tumor necrosis factor alpha on insulin-dependent diabetes mellitus in NOD mice. I. The early development of autoimmunity and the diabetogenic process.

1994 • 300 citations

Chronic Tumor Necrosis Factor Alters T Cell Responses by Attenuating T Cell Receptor Signaling

1997 • 287 citations

Autoimmune-prone mice share a promoter haplotype associated with reduced expression and function of the Fc receptor FcγRII

2000 • 214 citations

Local expression of transgene encoded TNF alpha in islets prevents autoimmune diabetes in nonobese diabetic (NOD) mice by preventing the development of auto-reactive islet-specific T cells.

1996 • 162 citations

A Dual Role for TNF-α in Type 1 Diabetes: Islet-Specific Expression Abrogates the Ongoing Autoimmune Process When Induced Late but Not Early During Pathogenesis

2001 • 152 citations

The Temporal Importance of TNFα Expression in the Development of Diabetes

2000 • 99 citations

Constitutive synthesis of tumor necrosis factor in the thymus.

1992 • 93 citations

Tumor necrosis factor-a and the progression of diabetes in non-obese diabetic mice

1999 • 70 citations

The role of TNFα and related cytokines in the development and function of the autoreactive T-cell repertoire

1997 • 70 citations

Thymus reticulum of autoimmune mice. 3. Ultrastructural study of NOD (non-obese diabetic) mouse thymus.

1991 • 17 citations

Thymic reticulum of autoimmune mice II: Ultrastructural studies of mice with lupus-like syndrome (NZB, BXSB, MRLl)

1990 • 9 citations