Designer dendritic cells for tolerance induction: guided not misguided missiles

Immunobiology of Dendritic Cells

2000 • 6,653 citations

THE NF-κB AND IκB PROTEINS: New Discoveries and Insights

1996 • 5,936 citations

Notch Signaling: Cell Fate Control and Signal Integration in Development

1999 • 5,826 citations

Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products.

1995 • 2,531 citations

Natural adjuvants: Endogenous activators of dendritic cells

1999 • 1,611 citations

Induction of Interleukin 10–Producing, Nonproliferating Cd4+ T Cells with Regulatory Properties by Repetitive Stimulation with Allogeneic Immature Human Dendritic Cells

2000 • 1,577 citations

Antigen-Specific Inhibition of Effector T Cell Function in Humans after Injection of Immature Dendritic Cells

2001 • 1,384 citations

Consequences of Cell Death

2000 • 1,382 citations

Induction of tolerance by IL-10-treated dendritic cells.

1997 • 1,263 citations

1α,25-Dihydroxyvitamin D3 Inhibits Differentiation, Maturation, Activation, and Survival of Dendritic Cells Leading to Impaired Alloreactive T Cell Activation

2000 • 1,253 citations

A Discrete Subpopulation of Dendritic Cells Transports Apoptotic Intestinal Epithelial Cells to T Cell Areas of Mesenteric Lymph Nodes

2000 • 908 citations

Class I–restricted Cross-Presentation of Exogenous Self-Antigens Leads to Deletion of Autoreactive CD8+ T Cells

1997 • 719 citations

Dendritic Cell Survival and Maturation Are Regulated by Different Signaling Pathways

1998 • 685 citations

Freshly Isolated Peyer's Patch, but Not Spleen, Dendritic Cells Produce Interleukin 10 and Induce the Differentiation of T Helper Type 2 Cells

1999 • 656 citations

IL-10 prevents the differentiation of monocytes to dendritic cells but promotes their maturation to macrophages

1998 • 505 citations

Resting Respiratory Tract Dendritic Cells Preferentially Stimulate T Helper Cell Type 2 (Th2) Responses and Require Obligatory Cytokine Signals for Induction of Th1 Immunity

1998 • 480 citations

Immature dendritic cells generated with low doses of GM-CSF in the absence of IL-4 are maturation resistant and prolong allograft survivalin vivo

2000 • 477 citations

Targeted Expression of Major Histocompatibility Complex (MHC) Class II Molecules Demonstrates that Dendritic Cells Can Induce Negative but Not Positive Selection of Thymocytes In Vivo

1997 • 459 citations

COSTIMULATORY MOLECULE-DEFICIENT DENDRITIC CELL PROGENITORS (MHC CLASS II+, CD80dim, CD86-) PROLONG CARDIAC ALLOGRAFT SURVIVAL IN NONIMMUNOSUPPRESSED RECIPIENTS12

1996 • 378 citations

Recombinant Galectin-1 and Its Genetic Delivery Suppress Collagen-Induced Arthritis via T Cell Apoptosis

1999 • 358 citations

Direct and indirect recognition: the role of MHC antigens in graft rejection

1999 • 347 citations

Expanding Dendritic Cells In Vivo Enhances the Induction of Oral Tolerance

1998 • 327 citations

CD4+ T Cell Tolerance to Parenchymal Self-Antigens Requires Presentation by Bone Marrow–derived Antigen-presenting Cells

1998 • 300 citations

The effect of calcineurin inhibitors and corticosteroids on the differentiation of human dendritic cells

2000 • 258 citations

Dendritic Cells Genetically Engineered to Express Fas Ligand Induce Donor-Specific Hyporesponsiveness and Prolong Allograft Survival

2000 • 237 citations

Recombinant Adenovirus Induces Maturation of Dendritic Cells via an NF-κB-Dependent Pathway

2000 • 232 citations

Effective Treatment of Established Murine Collagen-Induced Arthritis by Systemic Administration of Dendritic Cells Genetically Modified to Express IL-4

2001 • 217 citations

BLOCKADE OF THE CD40-CD40 LIGAND PATHWAY POTENTIATES THE CAPACITY OF DONOR-DERIVED DENDRITIC CELL PROGENITORS TO INDUCE LONG-TERM CARDIAC ALLOGRAFT SURVIVAL1,2

1997 • 215 citations

Contrasting Effects of TGF‐β1 and TNF‐α on the Development of Dendritic Cells from Progenitors in Mouse Bone Marrow

1997 • 214 citations

Serrate1-induced Notch signalling regulates the decision between immunity and tolerance made by peripheral CD4+ T cells

2000 • 207 citations

Granulocyte/macrophage colony-stimulating factor-stimulated hepatic dendritic cell progenitors prolong pancreatic islet allograft survival.

1995 • 202 citations

Aspirin Inhibits In Vitro Maturation and In Vivo Immunostimulatory Function of Murine Myeloid Dendritic Cells

2001 • 188 citations

Galectin-1 Specifically Modulates TCR Signals to Enhance TCR Apoptosis but Inhibit IL-2 Production and Proliferation

1999 • 188 citations

Mycophenolate Mofetil Impairs the Maturation and Function of Murine Dendritic Cells

2000 • 185 citations

Immunotherapy of NOD mice with bone marrow-derived dendritic cells.

1999 • 184 citations

Effects of Liver-Derived Dendritic Cell Progenitors on Th1- and Th2-Like Cytokine Responses In Vitro and In Vivo

2000 • 178 citations

RETROVIRAL DELIVERY OF VIRAL INTERLEUKIN-10 INTO MYELOID DENDRITIC CELLS MARKEDLY INHIBITS THEIR ALLOSTIMULATORY ACTIVITY AND PROMOTES THE INDUCTION OF T-CELL HYPORESPONSIVENESS1,2

1998 • 163 citations

Induction of antigen-specific immunosuppression by CD95L cDNA-transfected 'killer' dendritic cells

1999 • 159 citations

CD40 Ligation Ablates the Tolerogenic Potential of Lymphoid Dendritic Cells

2001 • 141 citations

Prolongation of Cardiac Allograft Survival Using Dendritic Cells Treated with NF-κB Decoy Oligodeoxyribonucleotides

2000 • 141 citations

Directed differentiation of dendritic cells from mouse embryonic stem cells

2000 • 140 citations

Transfer of dendritic cells (DC)ex vivostimulated with interferon-gamma (IFN-γ) down-modulates autoimmune diabetes in non-obese diabetic (NOD) mice

1999 • 102 citations

Evidence That an OX-2-Positive Cell Can Inhibit the Stimulation of Type 1 Cytokine Production by Bone Marrow-Derived B7-1 (and B7-2)-Positive Dendritic Cells

1999 • 78 citations

Blockade of T Cell Activation Using a Surface-Linked Single-Chain Antibody to CTLA-4 (CD152)

2000 • 73 citations

Induction of Transplant Tolerance with Immunodominant Allopeptide-pulsed Host Lymphoid and Myeloid Dendritic Cells

2001 • 66 citations

Autoantigen-pulsed dendritic cells induce tolerance to experimental allergic encephalomyelitis (EAE) in Lewis rats

2000 • 61 citations

A DENDRITIC CELL LINE GENETICALLY MODIFIED TO EXPRESS CTLA4-IG AS A MEANS TO PROLONG ISLET ALLOGRAFT SURVIVAL12

2000 • 60 citations

Feasibility of CTLA4Ig gene delivery and expression in vivo using retrovirally transduced myeloid dendritic cells that induce alloantigen-specific T cell anergy in vitro

2000 • 51 citations

Synergy in Induction of Increased Renal Allograft Survival after Portal Vein Infusion of Dendritic Cells Transduced to Express TGFβ and IL-10, along with Administration of CHO Cells Expressing the Regulatory Molecule OX-2

2000 • 50 citations

Prolonged skin allograft survival in mice treated with flt3-ligand-induced dendritic cells and anti-CD154 monoclonal antibody

1999 • 38 citations

Microchimerism, Donor Dendritic Cells, and Alloimmune Reactivity in Recipients of Flt3 Ligand-Mobilized Hemopoietic Cells: Modulation by Tacrolimus

2000 • 32 citations

CD8α+ (lymphoid-related) and CD8α− (myeloid) dendritic cells differentially regulate vascularized organ allograft survival

2001 • 9 citations