Induction of Transplant Tolerance with Immunodominant Allopeptide-pulsed Host Lymphoid and Myeloid Dendritic Cells

The Dendritic Cell System and its Role in Immunogenicity

1991 • 4,733 citations

T cell tolerance by clonal elimination in the thymus

1987 • 2,248 citations

Improved technique of heart transplantation in rats

1969 • 1,338 citations

Generation of mature dendritic cells from human blood An improved method with special regard to clinical applicability

1996 • 1,138 citations

Peptide-pulsed dendritic cells induce antigen-specific CTL-mediated protective tumor immunity.

1996 • 746 citations

Dendritic cells pulsed with protein antigens in vitro can prime antigen-specific, MHC-restricted T cells in situ.

1990 • 670 citations

The Role of the T Cell Receptor in Positive and Negative Selection of Developing T Cells

1990 • 589 citations

Targeted Expression of Major Histocompatibility Complex (MHC) Class II Molecules Demonstrates that Dendritic Cells Can Induce Negative but Not Positive Selection of Thymocytes In Vivo

1997 • 459 citations

Clonal Deletion Versus Clonal Anergy: The Role of the Thymus in Inducing Self Tolerance

1990 • 380 citations

Induction of antitumor immunity using bone marrow-generated dendritic cells.

1996 • 323 citations

Peptide contributes to the specificity of positive selection of CD8+ T cells in the thymus

1993 • 266 citations

Reentry of T cells to the adult thymus is restricted to activated T cells.

1991 • 263 citations

Positive selection of CD8+ T cells induced by major histocompatibility complex binding peptides in fetal thymic organ culture.

1993 • 221 citations

Generation of immunostimulatory dendritic cells from human CD34+ hematopoietic progenitor cells of the bone marrow and peripheral blood.

1995 • 175 citations

Effector T lymphocyte line cells migrate to the thymus and persist there

1982 • 165 citations

THYMIC RECOGNITION OF CLASS II MAJOR HISTOCOMPATIBILITY COMPLEX ALLOPEPTIDES INDUCES DONOR-SPECIFIC UNRESPONSIVENESS TO RENAL ALLOGRAFTS

1993 • 141 citations

STUDIES OF THE ROLE OF THE THYMIC ENVIRONMENT IN THE INDUCTION OF TOLERANCE TO MHC ANTIGENS

1985 • 127 citations

Mechanisms of acquired thymic tolerance in experimental autoimmune encephalomyelitis: thymic dendritic-enriched cells induce specific peripheral T cell unresponsiveness in vivo.

1995 • 121 citations

Lymphocytes selected in allogeneic thymic epithelium mediate dominant tolerance toward tissue grafts of the thymic epithelium haplotype.

1995 • 109 citations

Generation of Dendritic Cells In Vitro From Peripheral Blood Mononuclear Cells With Granulocyte-Macrophage-Colony-Stimulating Factor, Interleukin-4, and Tumor Necrosis Factor-α for Use in Cancer Immunotherapy

1997 • 108 citations

CD28 expression is not essential for positive and negative selection of thymocytes or peripheral T cell tolerance.

1996 • 105 citations

Induction of Neonatal Tolerance to Mls^aAntigens by CD8⁺T Cells

1990 • 103 citations

T cell recognition of allo-peptides in context of syngeneic MHC

1991 • 98 citations

INDIRECT ALLORECOGNITION IN ACQUIRED THYMIC TOLERANCE: INDUCTION OF DONOR-SPECIFIC TOLERANCE TO RAT CARDIAC ALLOGRAFTS BY ALLOPEPTIDE-PULSED HOST DENDRITIC CELLS1,2

1999 • 87 citations

Regulation of activation-induced cell death of mature T-lymphocyte populations

2000 • 87 citations

MECHANISMS OF ALLO-RECOGNITION

1994 • 85 citations

MAJOR HISTOCOMPATIBILITY COMPLEX CLASS I PEPTIDE-PULSED HOST DENDRITIC CELLS INDUCE ANTIGEN-SPECIFIC ACQUIRED THYMIC TOLERANCE TO ISLET CELLS 1,2

2000 • 82 citations

T cell recognition of allopeptides in context of syngeneic MHC.

1992 • 78 citations

Mechanisms of Acquired Thymic Tolerance In Vivo: Intrathymic Injection of Antigen Induces Apoptosis of Thymocytes and Peripheral T Cell Anergy

1998 • 59 citations

Thymus Requirement and Antigen Dependency in the “Infectious” Tolerance Pathway in Transplant Recipients

1998 • 59 citations

ACQUIRED SYSTEMIC TOLERANCE TO RAT CARDIAC ALLOGRAFTS INDUCED BY INTRATHYMIC INOCULATION OF SYNTHETIC POLYMORPHIC MHC CLASS I ALLOPEPTIDES1,2

1996 • 52 citations

Cross-presentation: inducing CD8 T cell immunity and tolerance

2000 • 48 citations

COMPARATIVE STUDIES OF SPECIFIC ACQUIRED SYSTEMIC TOLERANCE INDUCED BY INTRATHYMIC INOCULATION OF A SINGLE SYNTHETIC WISTAR-FURTH (RT1U) ALLO-MHC CLASS I (RT1.AU) PEPTIDE OR WAG (RT1U)-DERIVED CLASS I PEPTIDE1

1998 • 39 citations

Regulatory T cells in thymic epithelium‐induced tolerance. I. Suppression of mature peripheral non‐tolerant T cells

1995 • 38 citations

INDUCTION OF ALLOGRAFT NONRESPONSIVENESS AFTER INTRATHYMIC INOCULATION WITH DONOR CLASS I ALLOPEPTIDES

1997 • 35 citations

INDUCTION OF DONOR-SPECIFIC UNRESPONSIVENESS TO RAT CARDIAC ALLOGRAFTS BY PRETREATMENT WITH INTRATHYMIC DONOR MHC CLASS I ANTIGENS

1993 • 35 citations

In vitro characterization of rat bone marrow-derived dendritic cells and their precursors

1996 • 34 citations

In VivoMechanisms of Acquired Thymic Tolerance

1997 • 32 citations

MECHANISM OF ACQUIRED THYMIC TOLERANCE INDUCED BY A SINGLE MAJOR HISTOCOMPATIBILITY COMPLEX CLASS I PEPTIDE WITH THE DOMINANT EPITOPE: DIFFERENTIAL ANALYSIS OF REGULATORY CYTOKINES IN THE LYMPHOID AND INTRAGRAFT COMPARTMENTS1

1999 • 24 citations

MECHANISMS OF ACQUIRED THYMIC TOLERANCE: INDUCTION OF TRANSPLANT TOLERANCE BY ADOPTIVE TRANSFER OF IN VIVO ALLOMHC PEPTIDE ACTIVATED SYNGENEIC T CELLS 1

2001 • 22 citations

Migration patterns of dendritic cells in the rat: Comparison of the effects of γ and UV-B irradiation on the migration of dendritic cells and lymphocytes

1991 • 20 citations

Regulatory T Cells Maintain Peripheral Tolerance to Islet Allografts Induced by Intrathymic Injection of MHC Class I Allopeptides

1999 • 17 citations

Quantitative Analysis of Unidirectional 2-D Tissue Formation of Endothelial Cells

1992 • 6 citations

Deleted Work

1955 • 0 citations