Recombinant Galectin-1 and Its Genetic Delivery Suppress Collagen-Induced Arthritis via T Cell Apoptosis

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The proto-oncogene Bcl-2 and its role in regulating apoptosis

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Galectins. Structure and function of a large family of animal lectins.

1994 • 1,487 citations

Dominant interfering fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome

1995 • 1,477 citations

Apoptosis of T cells mediated by galectin-1

1995 • 1,056 citations

Anti-tumor necrosis factor ameliorates joint disease in murine collagen-induced arthritis.

1992 • 1,002 citations

Rheumatoid Arthritis

1996 • 960 citations

Expression of galectin-3 modulates T-cell growth and apoptosis.

1996 • 771 citations

The family of metazoan metal-independent β-galactoside-binding lectins: structure, function and molecular evolution

1993 • 504 citations

Unequal Death in T Helper Cell (Th)1 and Th2 Effectors: Th1, but not Th2, Effectors Undergo Rapid Fas/FasL-mediated Apoptosis

1997 • 460 citations

Relationship between Th1/Th2 cytokine patterns and the arthritogenic response in collagen‐induced arthritis

1996 • 317 citations

Galectin-1, an Endogenous Lectin Produced by Thymic Epithelial Cells, Induces Apoptosis of Human Thymocytes

1997 • 298 citations

Human thymic epithelial cells express an endogenous lectin, galectin-1, which binds to core 2 O-glycans on thymocytes and T lymphoblastoid cells.

1995 • 260 citations

Identification of an autocrine negative growth factor: Mouse β-galactoside-binding protein is a cytostatic factor and cell growth regulator

1991 • 239 citations

β-Galactoside-binding protein secreted by activated T cells inhibits antigen-induced proliferation of T cells

1998 • 237 citations

Normal development of mice carrying a null mutation in the gene encoding the L14 S-type lectin

1993 • 215 citations

Recombinant human β-galactoside binding lectin suppresses clinical and histological signs of experimental autoimmune encephalomyelitis

1990 • 203 citations

Amelioration of collagen-induced arthritis by CD95 (Apo-1/Fas)-ligand gene transfer.

1997 • 196 citations

Galectin-1 Specifically Modulates TCR Signals to Enhance TCR Apoptosis but Inhibit IL-2 Production and Proliferation

1999 • 188 citations

Differential ability of T cell subsets to undergo activation-induced cell death

1997 • 188 citations

Suppression of antigen-induced arthritis in rabbits by ex vivo gene therapy.

1996 • 188 citations

Activated Rat Macrophages Produce a Galectin-1-Like Protein That Induces Apoptosis of T Cells: Biochemical and Functional Characterization

1998 • 178 citations

Long-term control of erythropoietin secretion by doxycycline in mice transplanted with engineered primary myoblasts

1997 • 173 citations

Metastasis of human colon cancer is altered by modifying expression of the β-galactoside-binding protein galectin 3

1998 • 172 citations

T-cell apoptosis in autoimmune diseases: termination of inflammation in the nervous system and other sites with specialized immune-defense mechanisms

1997 • 165 citations

Expression of a transgenic class II Ab gene confers susceptibility to collagen‐induced arthritis

1994 • 160 citations

Apoptosis, fas and systemic autoimmunity: the MRL-Ipr/Ipr model

1994 • 151 citations

Amelioration of collagen-induced arthritis and suppression of interferon-?, interleukin-12, and tumor necrosis factor ? production by interferon-? gene therapy

1999 • 137 citations

Prevention and therapy with electrolectin of experimental autoimmune myasthenia gravis in rabbits

1983 • 137 citations

Synthesis of an endogeneous lectin, galectin-1, by human endothelial cells is up-regulated by endothelial cell activation

1995 • 121 citations

Bisindolylmaleimide VIII facilitates Fas-mediated apoptosis and inhibits T cell-mediated autoimmune diseases

1999 • 120 citations

Galectin-1 Modulates Human Melanoma Cell Adhesion to Laminin

1995 • 116 citations

Collagen-Induced Arthritis as a Model of Rheumatoid Arthritis

1994 • 111 citations

Introduction to Galectins.

1997 • 108 citations

Galectin-3 Down-Regulates IL-5 Gene Expression on Different Cell Types

1998 • 101 citations

Induction of apoptosis in the rheumatoid synovium by Fas ligand gene transfer

1998 • 99 citations

Apoptosis in the rheumatic diseases

1997 • 94 citations

Beta-galactoside-binding protein (beta GBP) alters the cell cycle, up-regulates expression of the alpha- and beta-chains of the IFN-gamma receptor, and triggers IFN-gamma-mediated apoptosis of activated human T lymphocytes.

1998 • 81 citations

Regulated expression of a 16-kd galectin-like protein in activated rat macrophages

1996 • 79 citations

Inhibition of transfer of collagen-induced arthritis into SCID mice by ex vivo infection of spleen cells with retroviruses expressing soluble tumor necrosis factor receptor.

1995 • 73 citations

Prevention of collagen-induced arthritis by gene delivery of soluble p75 tumour necrosis factor receptor

1998 • 65 citations

Specific Inhibition of Lymphocyte Proliferation and Induction of Apoptosis by CLL-I, a -Galactoside-Binding Lectin

1997 • 61 citations

β-Galactoside-Binding Protein (βGBP) Alters the Cell Cycle, Up-Regulates Expression of the α- and β-Chains of the IFN-γ Receptor, and Triggers IFN-γ-Mediated Apoptosis of Activated Human T Lymphocytes

1998 • 60 citations

Production and purification of a recombinant human 14 kDa β‐galactoside‐binding lectin

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Role of galaptin in ovarian carcinoma adhesion to extracellular matrix in vitro

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Pathways to gene therapy in rheumatoid arthritis

1996 • 44 citations

Galectin‐1 from ovine placenta

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Cloning and expression of murine IFNβ and a TNF antagonist for gene therapy of experimental allergic encephalomyelitis

1998 • 35 citations

Gene therapy in osteoarticular diseases: where are we?

1998 • 32 citations

Autologous hemopoietic stem cell transplantation. A possible cure for rheumatoid arthritis?

1997 • 31 citations

Bone marrow transplantation for multiple sclerosis: returning to Pandora's box

1997 • 26 citations

Apoptosis: potential for disease therapies

1998 • 24 citations

Gene therapy of rheumatoid arthritis via cytokine regulation: future perspectives

1995 • 24 citations

Amelioration of Autoimmune Reactions by Antigen-Induced Apoptosis of T Cells

1995 • 19 citations

Gene Therapy for Rheumatoid Arthritis

1998 • 17 citations

Antigenic determinants encoded by alternatively spliced exons of CD45 are determined by the polypeptide but influenced by glycosylation

1994 • 13 citations