Position effects in mice carrying a lacZ transgene in cis with the -globin LCR can be explained by a graded model

GERM-LINE TRANSFORMATION OF MICE

1986 • 1,165 citations

Chromatin as an essential part of the transcriptional mechanim

1992 • 853 citations

The SV40 72 base repair repeat has a striking effect on gene expression both in SV40 and other chimeric recombinants

1981 • 776 citations

Transcription complex stability and chromatin dynamics in vivo

1995 • 488 citations

Position effect variegation at fission yeast centromeres

1994 • 332 citations

Heterochromatin Effects on the Frequency and Duration of LCR-Mediated Gene Transcription

1996 • 328 citations

Definition of the minimal requirements within the human beta-globin gene and the dominant control region for high level expression.

1990 • 322 citations

Importance of globin gene order for correct developmental expression.

1991 • 294 citations

Enhancers increase the probability but not the level of gene expression.

1995 • 293 citations

Human gamma- to beta-globin gene switching in transgenic mice.

1990 • 291 citations

DNA methylation at a CCGG sequence in the large intron of the rabbit β-globin gene: tissue-specific variations

1978 • 268 citations

Each hypersensitive site of the human beta-globin locus control region confers a different developmental pattern of expression on the globin genes.

1993 • 226 citations

Position independence and proper developmental control of gamma-globin gene expression require both a 5' locus control region and a downstream sequence element.

1994 • 194 citations

Human globin locus activation region (LAR): role in temporal control

1990 • 189 citations

Transcriptional enhancers act in cis to suppress position-effect variegation.

1996 • 187 citations

Position-dependent variegation of globin transgene expression in mice.

1995 • 159 citations

Simian virus 40 enhancer increases number of RNA polymerase II molecules on linked DNA

1985 • 138 citations

[28] Application of LacZ gene fusions to postimplantation development

1993 • 125 citations

Separable cis-acting control elements for expression of the white gene of Drosophila.

1985 • 123 citations

Formation of stable transcription complexes as assayed by analysis of individual templates.

1988 • 118 citations

Variegated gene expression in mice

1997 • 116 citations

The human beta-globin locus activation region alters the developmental fate of a human fetal globin gene in transgenic mice.

1989 • 112 citations

Role of Gene Order in Developmental Control of Human γ- and β-Globin Gene Expression

1993 • 107 citations

Developmental regulation of human gamma-globin genes in transgenic mice.

1993 • 100 citations

Transcriptional repression by methylation of CpG

1992 • 93 citations

Position effect and related phenomena

1992 • 91 citations

High-level, erythroid-specific expression of the human alpha-globin gene in transgenic mice and the production of human hemoglobin in murine erythrocytes.

1989 • 83 citations

Simian virus 40 enhancer increases RNA polymerase density within the linked gene

1985 • 79 citations

A Globin Enhancer Acts by Increasing the Proportion of Erythrocytes Expressing a Linked Transgene

1997 • 77 citations

Chromatin domains as potential units of eukaryotic gene function

1994 • 72 citations

Role of gene order in developmental control of human gamma- and beta-globin gene expression.

1993 • 71 citations

The beta-globin locus control region enhances transcription of but does not confer position-independent expression onto the lacZ gene in transgenic mice.

1996 • 69 citations

A single beta-globin locus control region element (5' hypersensitive site 2) is sufficient for developmental regulation of human globin genes in transgenic mice.

1992 • 57 citations

Ectopic expression of Thy-1 in the kidneys of transgenic mice induces functional and proliferative abnormalities

1987 • 55 citations

Variegated Expression of a Globin Transgene Correlates with Chromatin Accessibility But Not Methylation Status

1996 • 49 citations

Cytosine methylation in gene-silencing mechanisms

1991 • 34 citations

Developmental Regulation of Human γ-Globin Genes in Transgenic Mice

1993 • 28 citations

[27] Application of LacZ gene fusions to preimplantation development

1993 • 28 citations

Position Independence and Proper Developmental Control of γ-Globin Gene Expression Require both a 5′ Locus Control Region and a Downstream Sequence Element

1994 • 27 citations

What does the locus control region control?

1992 • 27 citations

Position effect variegation in yeast

1994 • 25 citations

Elevated Hb F Associated with β‐Thalassaemia Trait: Haemoglobin Synthesis in Reticulocytes and in Blood BFU‐E

1981 • 6 citations