Definition of the minimal requirements within the human beta-globin gene and the dominant control region for high level expression.

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

Purification of Mouse Immunoglobulin Heavy‐Chain Messenger RNAs from Total Myeloma Tumor RNA

1980 • 2,696 citations

Position-independent, high-level expression of the human β-globin gene in transgenic mice

1987 • 1,955 citations

Insertion of DNA sequences into the human chromosomal β-globin locus by homologous recombination

1985 • 978 citations

Introns increase transcriptional efficiency in transgenic mice.

1988 • 733 citations

The "beta-like-globin" gene domain in human erythroid cells.

1985 • 634 citations

Protein-Binding Sites in Ig Gene Enhancers Determine Transcriptional Activity and Inducibility

1987 • 619 citations

Evidence for a locus activation region: the formation of developmentally stable hypersensitive sites in globin-expressing hybrids

1987 • 440 citations

Erythroid-specific expression of human beta-globin genes in transgenic mice.

1985 • 436 citations

The human beta-globin gene 3' enhancer contains multiple binding sites for an erythroid-specific protein.

1988 • 362 citations

Comparison of Intron-Dependent and Intron-Independent Gene Expression

1988 • 349 citations

A dominant control region from the human β-globin locus conferring integration site-independent gene expression

1989 • 346 citations

Lineage-specific expression of a human β-globin gene in murine bone marrow transplant recipients reconstituted with retrovirus-transduced stem cells

1988 • 341 citations

The β-globin dominant control region activates homologous and heterologous promoters in a tissue-specific manner

1989 • 302 citations

An erythroid-specific, developmental-stage-independent enhancer far upstream of the human "beta-like globin" genes.

1989 • 280 citations

Regulated expression of human Aγ-, β-, and hybrid γβ-globin genes in transgenic mice: Manipulation of the developmental expression patterns

1986 • 275 citations

A single erythroid-specific DNase I super-hypersensitive site activates high levels of human beta-globin gene expression in transgenic mice.

1989 • 269 citations

Developmental and spatial patterns of expression of the mouse homeobox gene, Hox2.1

1987 • 232 citations

Developmental regulation of a cloned adult β-globin gene in transgenic mice

1985 • 215 citations

The human beta-globin promoter; nuclear protein factors and erythroid specific induction of transcription.

1988 • 211 citations

Two 3' sequences direct adult erythroid-specific expression of human beta-globin genes in transgenic mice.

1987 • 202 citations

Splicing as a requirement for biogenesis of functional 16S mRNA of simian virus 40.

1979 • 185 citations

The human beta-globin gene contains multiple regulatory regions: identification of one promoter and two downstream enhancers.

1988 • 175 citations

The human β-globin gene contains a downstream developmental specific enhancer

1987 • 167 citations

DNA sequences that mediate attenuation of transcription from the mouse protooncogene myc.

1989 • 87 citations

High-level, erythroid-specific expression of the human alpha-globin gene in transgenic mice and the production of human hemoglobin in murine erythrocytes.

1989 • 83 citations

Upstream G gamma-globin and downstream beta-globin sequences required for stage-specific expression in transgenic mice.

1987 • 68 citations

Expression of the human beta-globin gene after retroviral transfer into murine erythroleukemia cells and human BFU-E cells.

1988 • 64 citations

Functional redundancy in the tissue-specific enhancer of the Drosophila Sgs-4 gene.

1988 • 42 citations

Upstream Gℽ-Globin and Downstream β-Globin Sequences Required for Stage-Specific Expression in Transgenic Mice

1987 • 23 citations

Expression of the Human β-Globin Gene After Retroviral Transfer into Murine Erythroleukemia Cells and Human BFU-E Cells

1988 • 15 citations