A single beta-globin locus control region element (5' hypersensitive site 2) is sufficient for developmental regulation of human globin genes in transgenic mice.

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Position-independent, high-level expression of the human β-globin gene in transgenic mice

1987 • 1,955 citations

Identification of two distinct regulatory regions adjacent to the human β-interferon gene

1983 • 1,076 citations

The "beta-like-globin" gene domain in human erythroid cells.

1985 • 634 citations

Evidence for a locus activation region: the formation of developmentally stable hypersensitive sites in globin-expressing hybrids

1987 • 440 citations

Review: Stratton Lecture 1990. Clinical implications of positive and negative hematopoietic stem cell regulators

1991 • 369 citations

Developmental regulation of human fetal-to-adult globin gene switching in transgenic mice

1990 • 364 citations

A dominant control region from the human β-globin locus conferring integration site-independent gene expression

1989 • 346 citations

The molecular basis of blood diseases

1988 • 341 citations

A major positive regulatory region located far upstream of the human alpha-globin gene locus.

1990 • 337 citations

Developmental regulation of β-globin gene switching

1988 • 328 citations

Definition of the minimal requirements within the human beta-globin gene and the dominant control region for high level expression.

1990 • 322 citations

Detailed analysis of the site 3 region of the human beta-globin dominant control region.

1990 • 320 citations

The β-globin dominant control region activates homologous and heterologous promoters in a tissue-specific manner

1989 • 302 citations

The beta-globin dominant control region: hypersensitive site 2.

1990 • 295 citations

Importance of globin gene order for correct developmental expression.

1991 • 294 citations

Human gamma- to beta-globin gene switching in transgenic mice.

1990 • 291 citations

Regulated expression of human Aγ-, β-, and hybrid γβ-globin genes in transgenic mice: Manipulation of the developmental expression patterns

1986 • 275 citations

A single erythroid-specific DNase I super-hypersensitive site activates high levels of human beta-globin gene expression in transgenic mice.

1989 • 269 citations

Rapid reprogramming of globin gene expression in transient heterokaryons

1986 • 246 citations

The 5′HS2 of the globin locus control region enhances transcription through the interaction of a multimeric complex binding at two functionally distinct NF-E2 binding sites.

1991 • 231 citations

Molecular analysis of the human beta-globin locus activation region.

1989 • 218 citations

Developmental regulation of a cloned adult β-globin gene in transgenic mice

1985 • 215 citations

An embryonic pattern of expression of a human fetal globin gene in transgenic mice

1986 • 204 citations

Two 3' sequences direct adult erythroid-specific expression of human beta-globin genes in transgenic mice.

1987 • 202 citations

Human γ-globin genes silenced independently of other genes in the β-globin locus

1991 • 191 citations

A point mutation in the Aγ-globin gene promoter in Greek hereditary persistence of fetal haemoglobin

1985 • 189 citations

DNasel hypersensitive sites 1, 2 and 3 of the human β-globin dominant control region direct position-independent expression

1990 • 186 citations

Regulated Expression of Globin Chains and the Erythroid Transcription Factor GATA-1 during Erythropoiesis in the Developing Mouse

1990 • 153 citations

Hypersensitive site 4 of the human β globin locus control region

1991 • 141 citations

The beta-globin stage selector element factor is erythroid-specific promoter/enhancer binding protein NF-E4.

1989 • 126 citations

Human beta-globin gene expression in transgenic mice is enhanced by a distant DNase I hypersensitive site.

1989 • 122 citations

Human beta-globin locus control region: analysis of the 5' DNase I hypersensitive site HS 2 in transgenic mice.

1991 • 121 citations

Conservation of the primary structure, organization, and function of the human and mouse beta-globin locus-activating regions.

1990 • 112 citations

The human beta-globin locus activation region alters the developmental fate of a human fetal globin gene in transgenic mice.

1989 • 112 citations

Regulated expression of globin chains and the erythroid transcription factor GATA-1 during erythropoiesis in the developing mouse.

1990 • 105 citations

Selective activation of human β - but not γ-globin gene in human fibroblast × mouse erythroleukaemia cell hybrids

1979 • 99 citations

Analysis of human hemoglobin switching in MEL × human fetal erythroid cell hybrids

1986 • 84 citations

Beta-globin locus activation regions: conservation of organization, structure, and function.

1990 • 75 citations

Negative Regulation of Globin Gene Expression during Megakaryocytic Differentiation of a Human Erythroleukemic Cell Line

1991 • 54 citations

Structure and function of the enhancer 3′ to the human^Aγ, globin gene

1990 • 46 citations

Activation of human beta-globin genes from nonerythroid cells by fusion with murine erythroleukemia cells.

1980 • 37 citations

Regulation of human fetal and adult globin genes in mouse erythroleukemia cells

1991 • 33 citations

DNase I super-hypersensitive sites direct high level erythroid expression of human alpha-, beta- and beta s- globin genes in transgenic mice.

1989 • 32 citations

Negative regulation of globin gene expression during megakaryocytic differentiation of a human erythroleukemic cell line.

1991 • 27 citations

Primary structure of the goat β-globin locus control region

1991 • 25 citations

Postnatal transition of γ‐globin gene expression in normal Japanese population

1991 • 6 citations