High-level, erythroid-specific expression of the human alpha-globin gene in transgenic mice and the production of human hemoglobin in murine erythrocytes.

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2001 • 133,517 citations

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

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1989 • 6,833 citations

Manipulating the mouse embryo: A laboratory manual

1986 • 4,548 citations

Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of S1 endonuclease-digested hybrids

1977 • 3,019 citations

Purification of Mouse Immunoglobulin Heavy‐Chain Messenger RNAs from Total Myeloma Tumor RNA

1980 • 2,696 citations

Position-independent, high-level expression of the human β-globin gene in transgenic mice

1987 • 1,955 citations

Mapping of RNA by a modification of the Berk-Sharp procedure: the 5′ termini of 15 S β-globin mRNA precursor and mature 10 S β-globin mRNA have identical map coordinates

1979 • 1,286 citations

Changes in size and secondary structure of the ribosomal transcription unit during vertebrate evolution

1975 • 1,188 citations

The Thalassæmia Syndromes.

1973 • 820 citations

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1997 • 765 citations

The Molecular Basis of Blood Diseases.

1987 • 648 citations

The "beta-like-globin" gene domain in human erythroid cells.

1985 • 634 citations

Evidence for a locus activation region: the formation of developmentally stable hypersensitive sites in globin-expressing hybrids

1987 • 440 citations

Human CD2 3′-flanking sequences confer high-level, T cell-specific, position-independent gene expression in transgenic mice

1989 • 385 citations

A dominant control region from the human β-globin locus conferring integration site-independent gene expression

1989 • 346 citations

Recombination at the human α-globin gene cluster: Sequence features and topological constraints

1987 • 345 citations

Differences in human α- and β-globin gene expression in mouse erythroleukemia cells: The role of intragenic sequences

1984 • 312 citations

THE MOLECULAR GENETICS OF HUMAN HEMOGLOBINS

1980 • 306 citations

The β-globin dominant control region activates homologous and heterologous promoters in a tissue-specific manner

1989 • 302 citations

A single erythroid-specific DNase I super-hypersensitive site activates high levels of human beta-globin gene expression in transgenic mice.

1989 • 269 citations

β-Globin gene inactivation by DNA translocation in γβ-thalassaemi

1983 • 266 citations

cis and trans activation of globin gene transcription in transient assays.

1983 • 257 citations

γ-β-Thalassaemia studies showing that deletion of the γ- and δ-genes influences β-globin gene expression in man

1980 • 184 citations

A distant gene deletion affects beta-globin gene function in an atypical gamma delta beta-thalassemia.

1985 • 106 citations

High-level erythroid expression of human alpha-globin genes in transgenic mice.

1989 • 96 citations

γδβ-Thalassaemias 1 and 2 are the result of a 100 kbp deletion in the human β-globin cluster

1986 • 95 citations

Haemoglobin Synthesis in β-Thalassaemia

1968 • 79 citations

Sequence organization and genomic complexity of primate θ1 globin gene, a novel α-globin-like gene

1986 • 70 citations

The gene for θ-globin is transcribed in human fetal erythroid tissues

1987 • 41 citations

Transcriptional promiscuity of the human alpha-globin gene.

1989 • 36 citations

Three mouse models of human thalassemia.

1981 • 36 citations

Evidence that the recently discovered θ1-globin gene is functional in higher primates

1987 • 28 citations