A Globin Enhancer Acts by Increasing the Proportion of Erythrocytes Expressing a Linked Transgene

Position-independent, high-level expression of the human β-globin gene in transgenic mice

1987 • 1,955 citations

GERM-LINE TRANSFORMATION OF MICE

1986 • 1,165 citations

DNA methylation and gene activity

1988 • 904 citations

Two distinct enhancers with different cell specificities coexist in the regulatory region of polyoma

1984 • 891 citations

The SV40 72 base repair repeat has a striking effect on gene expression both in SV40 and other chimeric recombinants

1981 • 776 citations

Expansions of transgene repeats cause heterochromatin formation and gene silencing in Drosophila

1994 • 506 citations

The Trithorax-like gene encodes the Drosophila GAGA factor

1994 • 409 citations

Locus Control Region Function and Heterochromatin-Induced Position Effect Variegation

1996 • 373 citations

The Molecular Basis of Blood Diseases

1994 • 370 citations

A major positive regulatory region located far upstream of the human alpha-globin gene locus.

1990 • 337 citations

Enhancers increase the probability but not the level of gene expression.

1995 • 293 citations

A yeast artificial chromosome covering the tyrosinase gene confers copy number-dependent expression in transgenic mice

1993 • 275 citations

Overcoming telomeric silencing: a trans-activator competes to establish gene expression in a cell cycle-dependent way.

1994 • 267 citations

Distal regulatory elements from the mouse metallothionein locus stimulate gene expression in transgenic mice.

1993 • 214 citations

Transcriptional enhancers act in cis to suppress position-effect variegation.

1996 • 187 citations

Conversion of Normal Behavior to Shiverer by Myelin Basic Protein Antisense cDNA in Transgenic Mice

1988 • 182 citations

Characterization of the Major Regulatory Element Upstream of the Human a-Globin Gene Cluster

1991 • 175 citations

Genes and genomes

1990 • 170 citations

The vagaries of variegating transgenes

1996 • 165 citations

Cis-acting sequences regulating expression of the human α-globin cluster lie within constitutively open chromatin

1992 • 162 citations

Position-dependent variegation of globin transgene expression in mice.

1995 • 159 citations

Simian virus 40 enhancer increases number of RNA polymerase II molecules on linked DNA

1985 • 138 citations

White gene expression, repressive chromatin domains and homeotic gene regulation in Drosophila

1994 • 126 citations

Formation of stable transcription complexes as assayed by analysis of individual templates.

1988 • 118 citations

Alpha-thalassemia caused by a large (62 kb) deletion upstream of the human alpha globin gene cluster

1990 • 112 citations

Conservation of the primary structure, organization, and function of the human and mouse beta-globin locus-activating regions.

1990 • 112 citations

The human beta-globin locus activation region alters the developmental fate of a human fetal globin gene in transgenic mice.

1989 • 112 citations

Characterization of the major regulatory element upstream of the human alpha-globin gene cluster.

1991 • 107 citations

Site-independent expression of the chicken βA-globin gene in transgenic mice

1990 • 106 citations

Developmental regulation of human gamma-globin genes in transgenic mice.

1993 • 100 citations

High-level erythroid expression of human alpha-globin genes in transgenic mice.

1989 • 96 citations

In vivo footprinting of the human alpha-globin locus upstream regulatory element by guanine and adenine ligation-mediated polymerase chain reaction.

1992 • 95 citations

Copy Number and Orientation Determine the Susceptibility of a Gene to Silencing by Nearby Heterochromatin in Drosophila

1996 • 94 citations

Age-dependent silencing of globin transgenes in the mouse

1996 • 93 citations

Position effect and related phenomena

1992 • 91 citations

An Enhancer/Locus Control Region Is Not Sufficient To Open Chromatin

1993 • 90 citations

High-level, erythroid-specific expression of the human alpha-globin gene in transgenic mice and the production of human hemoglobin in murine erythrocytes.

1989 • 83 citations

Simian virus 40 enhancer increases RNA polymerase density within the linked gene

1985 • 79 citations

Developmental Regulation of Human Globin Genes in Transgenic Mice

1985 • 74 citations

Analysis of the human alpha globin upstream regulatory element (HS-40) in transgenic mice.

1992 • 73 citations

Analysis of the human alpha-globin gene cluster in transgenic mice.

1993 • 65 citations

Inactivation of human alpha-globin gene expression by a de novo deletion located upstream of the alpha-globin gene cluster.

1990 • 61 citations

Do transgene arrays form heterochromatin in vertebrates?

1997 • 58 citations

A single beta-globin locus control region element (5' hypersensitive site 2) is sufficient for developmental regulation of human globin genes in transgenic mice.

1992 • 57 citations

Mosaic expression of a tyrosinase fusion gene in albino mice yields a heritable striped coat color pattern in transgenic homozygotes.

1991 • 52 citations

Random activation of a transgene under the control of a hybrid hCD2 locus control region/Ig enhancer regulatory element.

1995 • 52 citations

The LCR-like α-globin positive regulatory element functions as an enhancer in transiently transfected cells during erythroid differentiation

1992 • 48 citations

Clonal coat color variation due to a transforming gene expressed in melanocytes of transgenic mice.

1991 • 42 citations

Alpha-thalassemia resulting from deletion of regulatory sequences far upstream of the alpha-globin structural genes

1991 • 41 citations

Role of upstream DNase I hypersensitive sites in the regulation of human alpha globin gene expression

1993 • 31 citations

Mosaic expression of an Hprt transgene integrated in a region of Y heterochromatin

1994 • 25 citations

Position effect variegation in yeast

1994 • 25 citations

The major regulatory element upstream of the alpha-globin gene has classical and inducible enhancer activity

1993 • 25 citations

Macromolecular Synthesis and Degradation during Terminal Erythroid Cell Development

1990 • 9 citations