Cytosine methylation in gene-silencing mechanisms

Introduction of a Chimeric Chalcone Synthase Gene into Petunia Results in Reversible Co-Suppression of Homologous Genes in trans.

1990 • 2,386 citations

DNA Methylation and Gene Function

1980 • 2,069 citations

Sequence specificity of methylation in higher plant DNA

1981 • 719 citations

PREMEIOTIC INSTABILITY OF REPEATED SEQUENCES IN NEUROSPORA CRASSA

1990 • 648 citations

Reversible methylation and inactivation of marker genes in sequentially transformed tobacco plants

1989 • 544 citations

Alternative chromatin structure at CpG islands

1990 • 480 citations

The effect of T-DNA copy number, position and methylation on reporter gene expression in tobacco transformants

1990 • 373 citations

Sp1 transcription factor binds DNA and activates transcription even when the binding site is CpG methylated.

1988 • 308 citations

Methylation of CpG sequences in eukaryotic DNA

1981 • 289 citations

A sequence motif found in aDrosophilaheterochromatin protein is conserved in animals and plants

1991 • 273 citations

In vivo footprint and methylation analysis by PCR-aided genomic sequencing: comparison of active and inactive X chromosomal DNA at the CpG island and promoter of human PGK-1.

1990 • 250 citations

Dependence of position-effect variegation in Drosophila on dose of a gene encoding an unusual zinc-finger protein

1990 • 229 citations

Inactivation of the maize transposable element Activator (Ac) is associated with its DNA modification.

1987 • 228 citations

Non-random X-chromosome inactivation in mouse X-autosome translocation embryos—location of the inactivation centre

1983 • 208 citations

Specific protection of methylated CpGs in mammalian nuclei

1989 • 195 citations

Use of a HpaII-polymerase chain reaction assay to study DNA methylation in the Pgk-1 CpG island of mouse embryos at the time of X-chromosome inactivation.

1990 • 183 citations

DNA methylation and chromatin structure: a view from below

1990 • 166 citations

Targeted transformation of Ascobolus immersus and de novo methylation of the resulting duplicated DNA sequences.

1989 • 158 citations

DNA Methylation and Development

2015 • 135 citations

DNA methylation and late replication probably aid cell memory, and type I DNA reeling could aid chromosome folding and enhancer function

1990 • 133 citations

Establishment of de novo DNA methylation patterns

1990 • 129 citations

Deciphering the protein-DNA recognition code

1980 • 111 citations

Cell-type specific and differential regulation of the human metallothionein genes. Correlation with DNA methylation and chromatin structure.

1990 • 109 citations

A DNA signal from the Thy-1 gene defines de novo methylation patterns in embryonic stem cells.

1990 • 76 citations

In vitro DNA methylation inhibits gene expression in transgenic tobacco.

1990 • 73 citations

A pairing-sensitive element that mediates trans-inactivation is associated with the Drosophila brown gene.

1991 • 72 citations

Patterns of developmental and heritable change in methylation of theSuppressor-mutator transposable element

1989 • 68 citations

Understanding the molecular mechanism by which methylation influences gene expression

1989 • 59 citations

In vitro methylation of the promoter and enhancer of Pro alpha 1(I) collagen gene leads to its transcriptional inactivation

1991 • 59 citations

DNA methylation and cell memory

1989 • 50 citations

Mechanisms for the construction and developmental control of heterochromatin formation and imprinted chromosome domains

1990 • 46 citations

DNA methylation of maize transposable elements is correlated with activity

1990 • 45 citations

The quest for the X-inactivation centre

1991 • 24 citations

DNA methylation and specific protein—DNA interactions

1990 • 21 citations

A nuclear protein that binds preferentially to methylated DNA in vitro may play a role in the inaccessibility of methylated CpGs in mammalian nuclei

1990 • 17 citations

Gene transfer in plant protoplasts Inhibition of gene activity by cytosine methylation and expression of single‐stranded DNA constructs

1989 • 14 citations

Reactivation ofhprt on the inactive X chromosome with DNA demethylating agents

1989 • 11 citations