Chromatin domains as potential units of eukaryotic gene function

Position-independent, high-level expression of the human β-globin gene in transgenic mice

1987 • 1,955 citations

Chromosomal Subunits in Active Genes Have an Altered Conformation

1976 • 1,842 citations

Expression of a β-globin gene is enhanced by remote SV40 DNA sequences

1981 • 1,677 citations

A positive role for histone acetylation in transcription factor access to nucleosomal DNA

1993 • 1,116 citations

Structure of the nucleosome core particle at 7 Å resolution

1984 • 1,028 citations

A 5′ element of the chicken β-globin domain serves as an insulator in human erythroid cells and protects against position effect in Drosophila

1993 • 858 citations

The SV40 72 base repair repeat has a striking effect on gene expression both in SV40 and other chimeric recombinants

1981 • 776 citations

DNA methylation inhibits transcription indirectly via a methyl-CpG binding protein

1991 • 722 citations

A position-effect assay for boundaries of higher order chromosomal domains

1991 • 616 citations

A nuclear DNA attachment element mediates elevated and position-independent gene activity

1989 • 597 citations

A deletion of the human beta-globin locus activation region causes a major alteration in chromatin structure and replication across the entire beta-globin locus.

1990 • 477 citations

Silent domains are assembled continuously from the telomere and are defined by promoter distance and strength, and by SIR3 dosage.

1993 • 463 citations

Transcription factor access is mediated by accurately positioned nucleosomes on the mouse mammary tumor virus promoter.

1991 • 372 citations

Mapping polycomb-repressed domains in the bithorax complex using in vivo formaldehyde cross-linked chromatin

1993 • 360 citations

Decoding the nucleosome

1993 • 342 citations

An active tissue-specific enhancer and bound transcription factors existing in a precisely positioned nucleosomal array

1993 • 336 citations

Detailed analysis of the site 3 region of the human beta-globin dominant control region.

1990 • 320 citations

Importance of globin gene order for correct developmental expression.

1991 • 294 citations

The su(Hw) protein insulates expression of the Drosophila melanogaster white gene from chromosomal position-effects.

1993 • 280 citations

A yeast artificial chromosome covering the tyrosinase gene confers copy number-dependent expression in transgenic mice

1993 • 275 citations

The size of chromatin loops in HeLa cells.

1990 • 246 citations

Effects of histone H4 depletion on the cell cycle and transcription of Saccharomyces cerevisiae.

1988 • 225 citations

Nucleosomes are positioned with base pair precision adjacent to the alpha 2 operator in Saccharomyces cerevisiae.

1991 • 203 citations

Structure of the 30 nm chromatin fiber

1986 • 190 citations

Transcriptional regulation of multigene loci: multilevel control

1993 • 187 citations

Nucleosome disruption at the yeast PHO5 promoter upon PHO5 induction occurs in the absence of DNA replication

1992 • 159 citations

Z* DNA, the left-handed helical form of poly[d(G-C)] in MgCl2-ethanol, is biologically active.

1982 • 155 citations

A leucine zipper domain of the suppressor of Hairy-wing protein mediates its repressive effect on enhancer function.

1993 • 124 citations

A model for chromatin opening: stimulation of topoisomerase II and restriction enzyme cleavage of chromatin by distamycin.

1993 • 120 citations

Nucleosomes are phased along the mouse β-major globin gene in erythroid and nonerythroid cells

1986 • 119 citations

Germ Line Transmission of a Yeast Artificial Chromosome Spanning the Murine α ₁ (I) Collagen Locus

1993 • 118 citations

The immunoglobulin mu enhancer core establishes local factor access in nuclear chromatin independent of transcriptional stimulation.

1993 • 112 citations

The minimal requirements for activity in transgenic mice of hypersensitive site 3 of the beta globin locus control region.

1993 • 103 citations

Chromatin structure of the chicken beta-globin gene region. Sensitivity to DNase I, micrococcal nuclease, and DNase II.

1982 • 92 citations

Decoding the nucleosome

1993 • 83 citations

Structure of the chromatin axis during transcription

1988 • 72 citations

The ultrastructure of upstream and downstream regions of an active Balbiani ring gene

1989 • 43 citations

An ectopic copy of the Drosophila ftz associated SAR neither reorganizes local chromatin structure nor hinders elution of a chromatin fragment from isolated nuclei.

1991 • 25 citations

The regulatory domain organization of eukaryotic genomes: implications for stable gene transfer.

1992 • 7 citations