Protein kinase C activity modulates myelin gene expression in enriched oligodendrocytes

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Genomic sequencing.

1984 • 8,343 citations

Inositol trisphosphate, a novel second messenger in cellular signal transduction

1984 • 6,088 citations

The molecular heterogeneity of protein kinase C and its implications for cellular regulation

1988 • 4,243 citations

Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue.

1980 • 3,822 citations

Growth Factors and Cancer

1991 • 2,044 citations

A glial progenitor cell that develops in vitro into an astrocyte or an oligodendrocyte depending on culture medium

1983 • 2,009 citations

Monoclonal antibodies (O1 to O4) to oligodendrocyte cell surfaces: An immunocytological study in the central nervous system

1981 • 1,131 citations

Protein Kinase C Contains a Pseudosubstrate Prototope in Its Regulatory Domain

1987 • 1,020 citations

Protein kinase C as a possible receptor protein of tumor-promoting phorbol esters.

1983 • 890 citations

The Complete Primary Structure of Protein Kinase C—the Major Phorbol Ester Receptor

1986 • 878 citations

Development of oligodendrocytes and Schwann cells studied with a monoclonal antibody against galactocerebroside.

1982 • 842 citations

Platelet-derived growth factor promotes division and motility and inhibits premature differentiation of the oligodendrocyte/type-2 astrocyte progenitor ceil

1988 • 833 citations

Platelet-derived growth factor from astrocytes drives the clock that times oligodendrocyte development in culture

1988 • 760 citations

A role for platelet-derived growth factor in normal gliogenesis in the central nervous system

1988 • 756 citations

Removal of poly(A) and consequent degradation of c-fos mRNA facilitated by 3′ AU-rich sequences

1988 • 691 citations

Disappearance of Ca2+-sensitive, phospholipid-dependent protein kinase activity in phorbol ester-treated 3T3 cells

1984 • 643 citations

FGF modulates the PDGF-driven pathway of oligodendrocyte development

1990 • 586 citations

Cooperation between two growth factors promotes extended self-renewal and inhibits differentiation of oligodendrocyte-type-2 astrocyte (O-2A) progenitor cells.

1990 • 573 citations

The phorbol ester receptor: a phospholipid-regulated protein kinase

1985 • 522 citations

Clonal analysis of oligodendrocyte development in culture: Evidence for a developmental clock that counts cell divisions

1986 • 456 citations

A model for intracellular translocation of protein kinase C involving synergism between Ca2+ and phorbol esters

1985 • 446 citations

Characterization of cloned cDNA representing rat myelin basic protein: Absence of expression in brain of shiverer mutant mice

1983 • 382 citations

The amino acid sequences of the myelin-associated glycoproteins: homology to the immunoglobulin gene superfamily

1987 • 370 citations

Purified astrocytes promote the in vitro division of a bipotential glial progenitor cell.

1984 • 336 citations

Production of mRNA in chinese hamster cells: Relationship of the rate of synthesis to the cytoplasmic concentration of nine specific mRNA sequences

1979 • 326 citations

mRNA decay: Finding the right targets

1989 • 318 citations

Competitive inhibition by diacylglycerol of specific phorbol ester binding.

1984 • 306 citations

The expression of the growth associated protein B50/GAP43 in the olfactory system of neonatal and adult rats

1989 • 300 citations

Protein synthesis inhibitors differentially superinduce c-fos and c-jun by three distinct mechanisms: lack of evidence for labile repressors.

1992 • 297 citations

A synthetic peptide substrate for selective assay of protein kinase C

1990 • 292 citations

REGULATED mRNA STABILITY

1990 • 279 citations

A protein kinase C isozyme is translocated to cytoskeletal elements on activation.

1990 • 257 citations

The Role of the Poly(A) Sequence in Mammalian Messenger RN

1981 • 254 citations

Cellular and molecular aspects of myelin protein gene expression

1988 • 224 citations

Differential Down-regulation of Protein Kinase C Isozymes

1989 • 219 citations

Globin mRNA Species Containing Poly(A) Segments of Different Lengths

1976 • 183 citations

Elevated synthesis of an axonally transported protein correlates with axon outgrowth in normal and injured pyramidal tracts

1986 • 182 citations

Activation of the PKC‐isotypes α, β₁, γ, δ, and ε by phorbol esters of different biological activities

1991 • 178 citations

PDGF and intracellular signaling in the timing of oligodendrocyte differentiation.

1989 • 146 citations

In vitro analysis of the origin and maintenance of O-2Aadult progenitor cells.

1992 • 144 citations

Peptides that mimic the pseudosubstrate region of protein kinase C bind to acidic lipids in membranes

1991 • 139 citations

Differentiation signals in the CNS: Type-2 astrocyte development in vitro as a model system

1990 • 139 citations

Cell that are O4 antigen-positive and O1 antigen-negative differentiate into O1 antigen-positive oligodendrocytes

1982 • 135 citations

Effects of acidic and basic fibroblast growth factors on proliferation and maturation of cultured rat oligodendrocytes

1989 • 133 citations

Gliogenesis in rat optic nerve: Astrocytes are generated in a single wave before oligodendrocytes

1990 • 133 citations

Molecular cloning of a 2',3'-cyclic nucleotide 3'-phosphodiesterase: mRNAs with different 5' ends encode the same set of proteins in nervous and lymphoid tissues

1987 • 130 citations

Oligodendrocyte Adhesion Activates Protein Kinase C-Mediated Phosphorylation of Myelin Basic Protein

1986 • 117 citations

Differential regulation of oligodendrocyte markers by glucocorticoids: post-transcriptional regulation of both proteolipid protein and myelin basic protein and transcriptional regulation of glycerol phosphate dehydrogenase.

1989 • 109 citations

Transcriptional and post-transcriptional regulation of tyrosine hydroxylase gene by protein kinase C.

1990 • 100 citations

Neuromodulin (GAP43): a neuronal protein kinase C substrate is also present in 0-2A glial cell lineage. Characterization of neuromodulin in secondary cultures of oligodendrocytes and comparison with the neuronal antigen.

1990 • 97 citations

Expression of myelin proteolipid and basic protein mRNAS in cultured cells

1986 • 83 citations

Translocation and Activation of Protein Kinase C in Striatal Neurons in Primary Culture: Relationship to Phorbol Dibutyrate Actions on the Inositol Phosphate Generating System and Neurotransmitter Release

1989 • 81 citations

Characterization of Myelin Proteolipid mRNAs in Normal and Jimpy Mice

1986 • 80 citations

Short exposure to actinomycin D induces "reversible" translocation of protein B23 as well as "reversible" inhibition of cell growth and RNA synthesis in HeLa cells.

1990 • 79 citations

Characterization of human cDNA and genomic clones for glial fibrillary acidic protein

1990 • 76 citations

Developmental Expression of Proteolipid Protein and DM20 mRNAs and Proteins in the Rat Brain

1990 • 76 citations

Phorbol ester stimulation of protein kinase C activity and ribosomal DNA transcription. Role in hypertrophic growth of cultured cardiomyocytes.

1991 • 71 citations

Characterization of myelin proteolipid mRNAs in normal and jimpy mice.

1986 • 69 citations

Protein kinase C activation potently down-regulates the expression of its major substrate, 80K, in Swiss 3T3 cells.

1991 • 62 citations

Properties of the protein kinase C-phorbol ester interaction

1989 • 59 citations

Phorbol ester enhances morphological differentiation of oligodendrocytes in culture

1988 • 58 citations

Cytoskeletal reorganizations responsible for the phorbol ester-induced formation of cytoplasmic processes: possible involvement of intermediate filaments.

1990 • 57 citations

Differential expression of galactocerebroside, myelin basic protein, and 2′,3′‐cyclic nucleotide 3′‐phosphohydrolase during development of oligodendrocytes in vitro

1988 • 57 citations

Stability and degradation of mRNA

1991 • 54 citations

Spatial Distribution of mRNAs for Myelin Proteins in Primary Cultures of Mouse Brain

1990 • 50 citations

Mutations in the Myelin Proteolipid Protein Gene Alter Oligodendrocyte Gene Expression in Jimpy and Jimpy^msd Mice

1991 • 46 citations

Protein kinase C stimulation enhances the process formation of adult oligodendrocytes and induces proliferation

1991 • 44 citations

Age‐dependent decrease of process formation by cultured oligodendrocytes is augmented by protein kinase C stimulation

1991 • 43 citations

Transient reversion of O4⁺ Galc⁻ oligodendrocyte progenitor development in response to the phorbol ester TPA

1993 • 41 citations

Preparation and Properties of an Immunosorbent Column Specific for the Myelin Basic Protein

1981 • 36 citations

Temporal Expression of Myelin-Specific Components in Neonatal Mouse Brain Cultures: Evidence that 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase Appears Prior to Galactocerebroside

1990 • 31 citations

Development and regeneration in the central nervous system

1990 • 28 citations

Reduction of Muscarinic Receptor Density and of Guanine Nucleotide‐Stimulated Phosphoinositide Hydrolysis in Human SH‐SY5Y Neuroblastoma Cells Following Long‐Term Treatment with 12‐O‐Tetradecanoylphorbol 13‐Acetate or Mezerein

1990 • 27 citations

Phosphorylation of the MARCKS Protein (P87), a Major Protein Kinase C Substrate, Is Not an Obligatory Step in the Mitogenic Signaling Pathway of Basic Fibroblast Growth Factor in Rat Oligodendrocytes

1992 • 26 citations

Regulation of Myelin Basic Protein Gene Transcription in Normal and <i>shiverer </i>Mutant Mice

1991 • 26 citations

Phosphorylation of MARCKS (80‐KDA) protein, a major substrate for protein kinase C in oligodendroglial progenitors

1991 • 22 citations

Phosphorylation of Myelin-Associated Glycoprotein in Cultured Oligodendrocytes

1991 • 22 citations

The diacylglycerol analogue, 1,2-sn-dioctanoylglycerol, induces an increase in cytosolic free Ca2+ and cytosolic acidification of T lymphocytes through a protein kinase C-independent process

1989 • 21 citations

Control of Division and Differentiation in Oligodendrocyte‐Type‐2 Astrocyte Progenitor Cells

2007 • 20 citations

A general procedure for screening inhibitory antibodies: Application for identifying anti-protein kinase C antibodies

1988 • 20 citations

Phorbol‐12‐myristate‐13‐acetate (PMA) and inhibitors of protein kinase C alter glial fibrillary acidic protein (GFAP) mRNA levels

1991 • 17 citations

Recent Advances in Studies on Genes for Myelin Proteins

1991 • 11 citations

Amino acid composition of myelin proteins recovered from polyacrylamide gels

1973 • 9 citations

Differential regulation of basic protein phosphorylation by calcium phospholipid and cyclic‐AMP‐dependent protein kinases

1989 • 7 citations