Age‐dependent decrease of process formation by cultured oligodendrocytes is augmented by protein kinase C stimulation

Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

1982 • 4,786 citations

Staurosporine, a potent inhibitor of phospholipidCa++dependent protein kinase

1986 • 2,445 citations

Phorbol esters increase the amount of Ca2+, phospholipid-dependent protein kinase associated with plasma membrane

1983 • 1,304 citations

Calcium-activated, phospholipid-dependent protein kinase from rat brain. Subcellular distribution, purification, and properties.

1982 • 1,008 citations

Protein kinase C as a possible receptor protein of tumor-promoting phorbol esters.

1983 • 890 citations

Development of oligodendrocytes and Schwann cells studied with a monoclonal antibody against galactocerebroside.

1982 • 842 citations

Galactocerebroside is a specific cell-surface antigenic marker for oligodendrocytes in culture

1978 • 813 citations

MYELINATION IN RAT BRAIN: CHANGES IN MYELIN COMPOSITION DURING BRAIN MATURATION¹

1973 • 655 citations

Studies on a cyclic nucleotide-independent protein kinase and its proenzyme in mammalian tissues. I. Purification and characterization of an active enzyme from bovine cerebellum.

1977 • 587 citations

Overproduction of protein kinase C causesdisordered growth control in rat fibroblasts

1988 • 492 citations

Limited Proteolysis of Protein Kinase C Subspecies by Calcium-dependent Neutral Protease (Calpain)

1989 • 470 citations

Down-regulation of protein kinase C is due to an increased rate of degradation

1987 • 442 citations

Remyelination in multiple sclerosis

2009 • 442 citations

Fate of immunoprecipitable protein kinase C in GH3 cells treated with phorbol 12-myristate 13-acetate.

1985 • 387 citations

Interleukin-2 stimulates association of protein kinase C with plasma membrane

1985 • 384 citations

Insulin-like growth factor I/somatomedin C: a potent inducer of oligodendrocyte development.

1986 • 383 citations

c-myc gene expression is stimulated by agents that activate protein kinase C and does not account for the mitogenic effect of PDGF

1985 • 331 citations

Electron microscopic autoradiographic studies of gliogenesis in rat optic nerve. II. Time of origin

1976 • 315 citations

Alfred P. Sloan Jr. prize. Studies and prospectives of the protein kinase C family for cellular regulation

1989 • 298 citations

Neuroglial cells in the cerebral cortex of rats from young adulthood to old age: An electron microscope study

1974 • 293 citations

Phospholipid-sensitive Ca2+-dependent protein kinase from heart. II. Substrate specificity and inhibition by various agents.

1982 • 290 citations

Distribution of protein kinase C-like immunoreactive neurons in rat brain

1988 • 278 citations

Multiple sclerosis. Oligodendrocyte proliferation and differentiation in fresh lesions.

1989 • 266 citations

Multiple sclerosis. Oligodendrocyte survival and proliferation in an active established lesion.

1981 • 263 citations

Cell type-specific expression of protein kinase C isozymes in the rabbit cerebellum.

1988 • 232 citations

Differential Down-regulation of Protein Kinase C Isozymes

1989 • 219 citations

Protein kinase C activation in mixed micelles. Mechanistic implications of phospholipid, diacylglycerol, and calcium interdependencies.

1986 • 217 citations

Down regulation of phorbol diester receptors by proteolytic degradation of protein kinase C in a cultured cell line of fetal rat skin keratinocytes.

1986 • 183 citations

Postnatal development of a brain-specific subspecies of protein kinase C in rat

1988 • 165 citations

Immunocytochemical localization of beta II subspecies of protein kinase C in rat brain.

1989 • 159 citations

Regeneration of Oligodendroglia During Recovery from Demyelinating Disease

1977 • 159 citations

Autophosphorylation of Protein Kinase C at Three Separated Regions of Its Primary Sequence

1990 • 151 citations

Differential distribution of protein kinase C isozymes in the various regions of brain.

1987 • 150 citations

A point mutation at the putative ATP-binding site of protein kinase C alpha abolishes the kinase activity and renders it down-regulation-insensitive. A molecular link between autophosphorylation and down-regulation.

1990 • 145 citations

Characterization of a slowly proliferative cell along the oligodendrocyte differentiation pathway.

1987 • 134 citations

Radioautographic evidence for slow astrocyte turnover and modest oligodendrocyte production in the corpus callosum of adult mice infused with3H-thymidine

1988 • 133 citations

Oligodendrocyte Adhesion Activates Protein Kinase C-Mediated Phosphorylation of Myelin Basic Protein

1986 • 117 citations

Basic Protein in Brain Myelin Is Phosphorylated by Endogenous Phospholipid-Sensitive Ca²⁺-Dependent Protein Kinase

1982 • 116 citations

Immunological quantitation of phospholipid/Ca2+-dependent protein kinase and its fragments. Tissue levels, subcellular distribution, and ontogenetic changes in brain and heart.

1986 • 114 citations

Quantitation of protein kinase C by immunoblot—expression in different cell lines and response to phorbol esters

1987 • 114 citations

Immunological evidence for two physiological forms of protein kinase C.

1987 • 104 citations

Oligodendroglial Expression and Deposition of Four Major Myelin Constituents in the Myelin Sheath during Development

1986 • 85 citations

Remyelination in the Human Central Nervous System

1989 • 80 citations

Oligodendrocyte survival in Wallerian degeneration

1990 • 72 citations

Immunocytochemical localization of the alpha subspecies of protein kinase C in rat brain.

1990 • 67 citations

Remyelination in the central nervous system and the peripheral nervous system.

1988 • 60 citations

A Multidisciplinary Approach to Myelin Diseases

1987 • 59 citations

Effects of insulin and‐like growth factor (IGF‐I)on oligodendrocyte‐enriched glial culture

1988 • 59 citations

Phorbol ester enhances morphological differentiation of oligodendrocytes in culture

1988 • 58 citations

Tissue and species distribution and developmental variation of specific receptors for biologically active phorbol and ingenol esters

1981 • 54 citations

1-(5-isoquinolinesulfonyl)-2-methylpiperazine(H-7), a potent inhibitor of protein kinases, inhibits the differentiation of HL-60 cells induced by phorbol diester

1986 • 48 citations

Oligodendrocyte substratum adhesion modulates expression of adenylate cyclase-linked receptors.

1988 • 47 citations

Evolving Concepts and Issues in Remyelination

1989 • 26 citations

Cyclic AMP decreases the phosphorylation state of myelin basic proteins in rat brain cell cultures.

1987 • 21 citations

Biogenic Aldehyde Metabolism in Rat Brain: Subcellular Distribution of Aldose Reductase and Valproate‐Sensitive Aldehyde Reductase

1982 • 20 citations

Plasma membrane of cultured oligodendrocytes: III. Relatedness to myelin

1988 • 10 citations

The Plasticity of Mature Oligodendrocytes: A Role for Substratum in Phenotype Expression

1987 • 7 citations

Oligodendroglial Emergence and Deposition of Four Major Myelin Constituents in the Myelin Sheath During Development: An in Vivo Study

1987 • 3 citations