Properties of the protein kinase C-phorbol ester interaction

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

Microdetermination of Phosphorus

1956 • 7,242 citations

Studies and Perspectives of Protein Kinase C

1986 • 5,148 citations

Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

1982 • 4,786 citations

Production of large unilamellar vesicles by a rapid extrusion procedure. Characterization of size distribution, trapped volume and ability to maintain a membrane potential

1985 • 2,037 citations

Phorbol esters increase the amount of Ca2+, phospholipid-dependent protein kinase associated with plasma membrane

1983 • 1,304 citations

Measurement of protein-binding phenomena by gel filtration

1962 • 1,275 citations

Phorbol diester receptor copurifies with protein kinase C.

1983 • 1,185 citations

Calcium-activated, phospholipid-dependent protein kinase from rat brain. Subcellular distribution, purification, and properties.

1982 • 1,008 citations

Protein kinase C as a possible receptor protein of tumor-promoting phorbol esters.

1983 • 890 citations

The Complete Primary Structure of Protein Kinase C—the Major Phorbol Ester Receptor

1986 • 878 citations

Studies on a cyclic nucleotide-independent protein kinase and its proenzyme in mammalian tissues. I. Purification and characterization of an active enzyme from bovine cerebellum.

1977 • 587 citations

The Role of Protein Kinase C in Transmembrane Signalling

1986 • 557 citations

The phorbol ester receptor: a phospholipid-regulated protein kinase

1985 • 522 citations

Tissue-specific expression of three distinct types of rabbit protein kinase C

1987 • 469 citations

A model for intracellular translocation of protein kinase C involving synergism between Ca2+ and phorbol esters

1985 • 446 citations

Decrease in cytosolic calcium/phospholipid-dependent protein kinase activity following phorbol ester treatment of EL4 thymoma cells.

1982 • 417 citations

Isozymic forms of rat brain Ca2+-activated and phospholipid-dependent protein kinase.

1986 • 389 citations

A Spatial-Temporal Model of Cell Activation

1988 • 347 citations

Expression and Properties of Two Types of Protein Kinase C: Alternative Splicing from a Single Gene

1987 • 317 citations

Competitive inhibition by diacylglycerol of specific phorbol ester binding.

1984 • 306 citations

Characterization of a specific phorbol ester aporeceptor in mouse brain cytosol.

1983 • 292 citations

Purification to homogeneity of protein kinase C from bovine brain-identity with the phorbol ester receptor.

1984 • 283 citations

Mechanism of action of the phorbol ester tumor promoters: Specific receptors for lipophilic ligands

1984 • 209 citations

Ca2+-dependent hydrophobic-interaction chromatography. Isolation of a novel Ca2+-binding protein and protein kinase C from bovine brain

1984 • 202 citations

Role of substrate in imparting calcium and phospholipid requirements to protein kinase C activation

1987 • 168 citations

Purification and characterization of three types of protein kinase C from rabbit brain cytosol.

1987 • 168 citations

Identification of high-affinity phorbol ester receptor in cytosol of EL4 thymoma cells: requirement for calcium, magnesium, and phospholipids.

1983 • 157 citations

Specific binding of phorbol ester tumor promoters to mouse skin

1980 • 152 citations

Association of protein kinase C with phospholipid vesicles

1987 • 149 citations

Factors influencing chelator-stable, detergent-extractable, phorbol diester-induced membrane association of protein kinase C. Differences between Ca2+-induced and phorbol ester-stabilized membrane bindings of protein kinase C.

1986 • 144 citations

Differential expression of multiple protein kinase C subspecies in rat central nervous tissue

1987 • 135 citations

Properties of membrane-inserted protein kinase C

1988 • 119 citations

Rapid Assay of Binding of Tumor-Promoting Phorbol Esters to Protein Kinase C1

1986 • 84 citations

Constitutive activity of membrane-inserted protein kinase C

1988 • 83 citations

Cytosolic calcium regulates phorbol diester binding affinity in intact phagocytes.

1986 • 76 citations

Conversion of protein kinase C from a Ca2+-dependent to an independent form of phorbol ester-binding protein by digestion with trypsim

1986 • 74 citations

Association of protein kinase C with phospholipid monolayers: two-stage irreversible binding

1988 • 66 citations

Phospholipid and Ca⁺⁺ dependency of phorbol ester receptors

1985 • 53 citations

Measurement of phorbol ester receptors in intact cells and subcellular fractions

1987 • 51 citations

Ca2+-independent binding of [3H]phorbol dibutyrate to protein kinase C is supported by protamine and other polycations

1988 • 11 citations