Mutations in the Myelin Proteolipid Protein Gene Alter Oligodendrocyte Gene Expression in Jimpy and Jimpy^msd Mice

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue.

1980 • 3,822 citations

Cloning in single-stranded bacteriophage as an aid to rapid DNA sequencing

1980 • 3,476 citations

Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of S1 endonuclease-digested hybrids

1977 • 3,019 citations

Transcriptional regulation of the ovalbumin and conalbumin genes by steroid hormones in chick oviduct.

1979 • 975 citations

Transcription and Translation — A Practical Approach

1985 • 811 citations

Transcripts from the Cellular Homologs of Retroviral Oncogenes: Distribution Among Chicken Tissues

1982 • 406 citations

Characterization of cloned cDNA representing rat myelin basic protein: Absence of expression in brain of shiverer mutant mice

1983 • 382 citations

Nucleotide sequences of two mRNAs for rat brain myelin proteolipid protein

1985 • 345 citations

Production of mRNA in chinese hamster cells: Relationship of the rate of synthesis to the cytoplasmic concentration of nine specific mRNA sequences

1979 • 326 citations

[58] Direct sequencing of denatured plasmid DNA

1987 • 246 citations

Transcripts from the Cellular Homologs of Retroviral Oncogenes: Distribution Among Chicken Tissues

1982 • 241 citations

Cellular and molecular aspects of myelin protein gene expression

1988 • 224 citations

Oligodendroglial cell death in jimpy mice: an explanation for the myelin deficit

1986 • 218 citations

Mutation of the proteolipid protein gene PLP in a human X chromosome-linked myelin disorder.

1989 • 205 citations

Aberrant splicing of proteolipid protein mRNA in the dysmyelinating jimpy mutant mouse.

1987 • 174 citations

A Single Nucleotide Difference in the Gene for Myelin Proteolipid Protein Defines the Jimpy Mutation in Mouse

1987 • 167 citations

Animal Models of Genetic Disorders of Myelin

1984 • 159 citations

Pelizaeus-Merzbacher disease: an X-linked neurologic disorder of myelin metabolism with a novel mutation in the gene encoding proteolipid protein.

1989 • 157 citations

RNA processing errors in patients with beta-thalassemia.

1982 • 150 citations

Direct sequencing of enzymatically amplified human genomic DNA.

1988 • 141 citations

The structure of bovine brain myelin proteolipid and its organization in myelin.

1984 • 137 citations

Immunocytochemical localization of glycerol-3-phosphate dehydrogenase in rat oligodendrocytes

1980 • 135 citations

Structure and expression of the mouse myelin proteolipid protein gene

1987 • 130 citations

Structure and molecular arrangement of proteolipid protein of central nervous system myelin.

1984 • 130 citations

Myelin-deficient rat: a point mutation in exon III (A----C, Thr75----Pro) of the myelin proteolipid protein causes dysmyelination and oligodendrocyte death.

1989 • 129 citations

Increased proliferation of oligodendrocytes in the hypomyelinated mouse mutant-jimpy

1982 • 123 citations

Developmental Expression of the Myelin Proteolipid Protein and Basic Protein mRNAs in Normal and Dysmyelinating Mutant Mice

1987 • 112 citations

Differential regulation of oligodendrocyte markers by glucocorticoids: post-transcriptional regulation of both proteolipid protein and myelin basic protein and transcriptional regulation of glycerol phosphate dehydrogenase.

1989 • 109 citations

Jimpy, a new totally sex-linked gene in the house mouse

1954 • 105 citations

Conservative amino acid substitution in the myelin proteolipid protein of jimpymsd mice.

1990 • 96 citations

An AG→GG transition at a splice site in the myelin proteolipid protein gene in jimpy mice results in the removal of an exon

1987 • 95 citations

Expression of Myelin Proteolipid Protein and Basic Protein in Normal and Dysmyelinating Mutant Mice

1986 • 93 citations

A neurological mutation (msd) of the mouse causing a deficiency of myelin synthesis

1970 • 87 citations

Conservative amino acid substitution in the myelin proteolipid protein of jimpymsd mice

1990 • 85 citations

Oligodendroglial Expression and Deposition of Four Major Myelin Constituents in the Myelin Sheath during Development

1986 • 85 citations

Expression of galactocerebroside in developing normal and jimpy oligodendrocytesin situ

1988 • 85 citations

Myelin Proteolipid Protein Gene Expression in Jimpy and Jimpy^msdMice

1988 • 82 citations

Characterization of Myelin Proteolipid mRNAs in Normal and Jimpy Mice

1986 • 80 citations

The initial events in myelin synthesis: orientation of proteolipid protein in the plasma membrane of cultured oligodendrocytes.

1989 • 76 citations

Developmental Expression of Proteolipid Protein and DM20 mRNAs and Proteins in the Rat Brain

1990 • 76 citations

Characterization of myelin proteolipid mRNAs in normal and jimpy mice.

1986 • 69 citations

Regional distribution of myelin basic protein in the central nervous system of quaking, jimpy, and normal mice during development and aging

1981 • 66 citations

Expression of myelin proteins in the developing human spinal cord: Cloning and sequencing of human proteolipid protein cDNA

1987 • 64 citations

Effect of the Jimpy Mutation on Expression of Myelin Proteins in Heterozygous and Hemizygous Mouse Brain

1984 • 61 citations

Abnormal Expression of the Myelin‐Associated Glycoprotein in the Central Nervous System of Dysmyelinating Mutant Mice

1985 • 57 citations

DNA Preparation from Cultured Cells and Tissue

1986 • 57 citations

A defect in the cell cycle of neuroglia in the myelin deficient jimpy mouse

1987 • 57 citations

Use of chimeras to transmit lethal genes in the mouse and to demonstrate allelism of the two X‐linked male lethal genes jp and msd

1973 • 44 citations

The differentiation of synthesis from incorporation of basic protein in quaking mutant mouse myelin

1977 • 37 citations

Glucocorticoids regulate the transcription of glycerol phosphate dehydrogenase in cultured glial cells.

1985 • 32 citations

Myelin basic protein gene expression in quaking, jimpy, and myelin synthesis-deficient mice

1984 • 32 citations

Transcriptional Regulation Studies of Myelin-Associated Genes in Myelin-DeficientMutant Rats

1990 • 30 citations

Developmental expression of neural cell type‐specific mRNA markers in the myelin‐deficient mutant rat brain: Inhibition of oligodendrocyte differentiation

1988 • 29 citations

Expression of myelin protein genes in quaking mouse brain

1988 • 21 citations