A protein kinase C isozyme is translocated to cytoskeletal elements on activation.

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

The molecular heterogeneity of protein kinase C and its implications for cellular regulation

1988 • 4,243 citations

Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene

1984 • 3,150 citations

Phorbol esters increase the amount of Ca2+, phospholipid-dependent protein kinase associated with plasma membrane

1983 • 1,304 citations

Immunochemical analysis of myosin heavy chain during avian myogenesis in vivo and in vitro.

1982 • 932 citations

Calcium-mobilizing receptors, polyphosphoinositides, and the generation of second messengers.

1986 • 831 citations

Specific interaction between phosphatidylinositol 4,5-bisphosphate and profilactin

1985 • 824 citations

The structure, expression, and properties of additional members of the protein kinase C family.

1988 • 706 citations

Protein kinase C phosphorylation of the EGF receptor at a threonine residue close to the cytoplasmic face of the plasma membrane

1984 • 656 citations

Modulation of gelsolin function by phosphatidylinositol 4,5-bisphosphate

1987 • 624 citations

Studies on a cyclic nucleotide-independent protein kinase and its proenzyme in mammalian tissues. I. Purification and characterization of an active enzyme from bovine cerebellum.

1977 • 587 citations

Protein kinase C activation by diacylglycerol second messengers

1986 • 498 citations

Stimulation of hypertrophy of cultured neonatal rat heart cells through an alpha 1-adrenergic receptor and induction of beating through an alpha 1- and beta 1-adrenergic receptor interaction. Evidence for independent regulation of growth and beating.

1985 • 485 citations

Differentiation of rat myocytes in single cell cultures with and without proliferating nonmyocardial cells. Cross-striations, ultrastructure, and chronotropic response to isoproterenol.

1982 • 454 citations

Activation of protein kinase C potentiates isoprenaline-induced cyclic AMP accumulation in rat pinealocytes

1985 • 415 citations

Ia binding ligands and cAMP stimulate nuclear translocation of PKC in B lymphocytes

1987 • 321 citations

Association of type 3 protein kinase C with focal contacts in rat embryo fibroblasts.

1989 • 310 citations

A tumor promoter induces rapid and coordinated reorganization of actin and vinculin in cultured cells.

1984 • 303 citations

The outer boundary of the cytoskeleton: a lamina derived from plasma membrane proteins

1979 • 298 citations

Alpha 1-adrenergic and muscarinic cholinergic stimulation of phosphoinositide hydrolysis in adult rat cardiomyocytes.

1985 • 298 citations

Interaction of protein kinase C with membranes is regulated by Ca2+, phorbol esters, and ATP.

1985 • 274 citations

Cardiac myocyte hypertrophy is associated with c-myc protooncogene expression.

1986 • 263 citations

Dynamic membrane-cytoskeletal interactions: specific association of integrin and talin arises in vivo after phorbol ester treatment of peripheral blood lymphocytes.

1988 • 230 citations

Type 3 protein kinase C localization to the nuclear envelope of phorbol ester-treated NIH 3T3 cells.

1989 • 221 citations

The heterogeneity of protein kinase C in various rat tissues

1988 • 208 citations

Angiotensin II increases spontaneous contractile frequency and stimulates calcium current in cultured neonatal rat heart myocytes: insights into the underlying biochemical mechanisms.

1988 • 199 citations

Differential acute and chronic response of protein kinase C in cultured neonatal rat heart myocytes to α1-adrenergic and phorbol ester stimulation

1988 • 185 citations

Phosphorylation of smooth muscle heavy meromyosin by calcium-activated, phospholipid-dependent protein kinase. The effect on actin-activated MgATPase activity.

1983 • 174 citations

Domain structure and phosphorylation of protein kinase C.

1987 • 168 citations

Identification of a polyphosphoinositide-modulated domain in gelsolin which binds to the sides of actin filaments.

1988 • 148 citations

Diacylglycerol in large α-actinin/actin complexes and in the cytoskeleton of activated platelets

1985 • 147 citations

Tumor-promoting phorbol esters inhibit cardiac functions and induce redistribution of protein kinase C in perfused beating rat heart.

1987 • 139 citations

Phosphorylation of cardiac troponin inhibitory subunit (troponin I) and tropomyosin-binding subunit (troponin T) by cardiac phospholipid-sensitive Ca2+-dependent protein kinase

1983 • 139 citations

Differential expression of multiple protein kinase C subspecies in rat central nervous tissue

1987 • 135 citations

Growth inhibition by protein kinase C late in mitogenesis

1987 • 133 citations

Protein kinase C in fibroblasts. Characteristics of its intracellular location during growth and after exposure to phorbol esters and other mitogens.

1987 • 127 citations

Phosphorylation of glycogen synthase by the Ca2+- and phospholipid-activated protein kinase (protein kinase C).

1984 • 127 citations

Alpha-1 adrenoceptor-mediated positive inotropic effect and inositol trisphosphate increase in mammalian heart.

1988 • 110 citations

Immunochemical identification of protein kinase C isozymes as products of discrete genes

1987 • 105 citations

Transmembrane signaling through B cell MHC class II molecules: anti-Ia antibodies induce protein kinase C translocation to the nuclear fraction.

1987 • 99 citations

Distinct cellular and regional localization of immunoreactive protein kinase C in rat brain.

1987 • 98 citations

Protein kinase C and phosphatidylserine bind to Mr 110,000/115,000 polypeptides enriched in cytoskeletal and postsynaptic density preparations.

1986 • 95 citations

Protein kinase C and cAMP‐dependent protein kinase induce opposite effects on actin polymerizability

1987 • 83 citations

Activation of α-Protein Kinase C Leads to Association with Detergent-Insoluble Components of GH₄C₁Cells

1990 • 79 citations

Nicotinic and muscarinic agonists stimulate rapid protein kinase C translocation in PC12 cells

1989 • 71 citations

Growth factors and TPA stimulate DNA synthesis and alter the morphology of cultured terminally differentiated adult rat cardiac muscle cells

1988 • 69 citations

Distribution of myosin isozymes within single cardiac cells. An immunohistochemical study.

1983 • 69 citations

Effect of phorbol esters on contractile state and calcium flux in cultured chick heart cells

1987 • 69 citations

Immunocytochemical evidence for translocation of protein kinase C in human megakaryoblastic leukemic cells: synergistic effects of Ca2+ and activators of protein kinase C on the plasma membrane association.

1988 • 63 citations

Isolation and characterization of protein kinase C from Y-1 adrenal cell cytoskeleton.

1989 • 63 citations

Catecholamine secretion from digitonin-treated PC12 cells. Effects of Ca2+, ATP, and protein kinase C activators.

1986 • 61 citations

Subcellular distribution and immunocytochemical localization of protein kinase C in myocardium, and phosphorylation of troponin in isolated myocytes stimulated by isoproterenol or phorbol ester

1989 • 47 citations

Phosphorylation of skeletal-muscle troponin I and troponin T by phospholipid-sensitive Ca2+-dependent protein kinase and its inhibition by troponin C and tropomyosin

1984 • 46 citations

Phosphorylation of bovine cardiac C-protein by protein kinase C

1985 • 43 citations

Special type of morphological reorganization induced by phorbol ester: reversible partition of cell into motile and stable domains.

1987 • 37 citations

Phorbol myristate acetate (PMA) suppresses polarization and locomotion and alters F‐actin content of walker carcinosarcoma cells

1985 • 37 citations

Specific stimulation of histone H2B and H4 phosphorylation in mouse lymphocytes by 12-O-tetradecanoylphorbol 13-acetate.

1985 • 36 citations

Phosphatidylinositol cycle and its possible involvement in the regulation of cytoskeleton‐membrane interactions

1988 • 36 citations

Selective effects of phorbol 12-myristate 13-acetate on myofibrils and 10-nm filaments.

1980 • 36 citations

Characterization of the membrane-bound protein kinase C and its substrate proteins in canine cardiac sarcolemma

1986 • 34 citations

Carbachol induces desensitization of cardiac β-adrenergic receptors through muscarinic M1 receptors

1985 • 24 citations

Translocation of protein kinase C to a Triton-insoluble sub-cellular compartment induced by the lipophilic gold compound auranofin

1988 • 22 citations

A general procedure for screening inhibitory antibodies: Application for identifying anti-protein kinase C antibodies

1988 • 20 citations