Endonuclease activation during apoptosis: The role of cytosolic Ca2+ and pH

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Cell Death: The Significance of Apoptosis

1980 • 7,281 citations

Biological Applications of Ionophores

1976 • 1,829 citations

Programmed cell death involved in the schizolysigenous formation of the secretory cavity in Citrus sinensis L. (Osbeck)

2010 • 1,629 citations

Chromatin cleavage in apoptosis: Association with condensed chromatin morphology and dependence on macromolecular synthesis

1984 • 1,586 citations

Glucocorticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to cell death.

1984 • 1,441 citations

Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: a cautionary note.

1989 • 937 citations

Activation of programmed cell death (apoptosis) by cisplatin, other anticancer drugs, toxins and hyperthermia

1990 • 887 citations

Programmed cell death and extrathymic reduction of Vβ8+CD4+ T cells in mice tolerant to Staphylococcus aureus enterotoxin B

1991 • 675 citations

Protons and Anaerobiosis

1983 • 572 citations

Glucocorticoids activate a suicide process in thymocytes through an elevation of cytosolic Ca2+ concentration

1989 • 549 citations

Calcium‐activated DNA fragmentation kills immature thymocytes

1989 • 533 citations

2,3,7,8-Tetrachlorodibenzo- p -Dioxin Kills Immature Thymocytes by Ca ²⁺ -Mediated Endonuclease Activation

1988 • 460 citations

Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy

1991 • 376 citations

Aurintricarboxylic acid rescues PC12 cells and sympathetic neurons from cell death caused by nerve growth factor deprivation: correlation with suppression of endonuclease activity.

1991 • 359 citations

Identification, purification, and characterization of a calcium-dependent endonuclease (NUC18) from apoptotic rat thymocytes. NUC18 is not histone H2B.

1991 • 301 citations

Calcium-activated DNA Fragmentation in Rat Liver Nuclei

1989 • 281 citations

Regulation of apoptosis in interleukin-3-dependent hemopoietic cells by interleukin-3 and calcium ionophores.

1990 • 226 citations

Tumor necrosis factor alpha induces apoptosis in mammary adenocarcinoma cells by an increase in intranuclear free Ca2+ concentration and DNA fragmentation.

1992 • 190 citations

Programmed death of nonproliferating androgen-independent prostatic cancer cells.

1991 • 159 citations

Activation of internucleosomal DNA cleavage in human CEM lymphocytes by glucocorticoid and novobiocin. Evidence for a non-Ca2(+)-requiring mechanism(s).

1990 • 134 citations

Interleukin 1 inhibits T cell receptor-mediated apoptosis in immature thymocytes.

1990 • 125 citations

Cation transport and specificity of ionomycin. Comparison with ionophore A23187 in rat liver mitochondria.

1980 • 112 citations

Isolation and purification of calcium and magnesium dependent endonuclease from rat liver nuclei

1974 • 102 citations

Calcium‐dependent DNA fragmentation in human synovial cells exposed to cold shock

1990 • 82 citations

NK cell‐induced cytotoxicity is dependent on a Ca²⁺ increase in the target

1990 • 73 citations

Ratiometric measurement of intracellular pH in cultured human keratinocytes using carboxy‐SNARF‐1 and flow cytometry

1991 • 66 citations

Lesions of the rostral ventrolateral rvlm but not rostral ventromedial medulla rvmm attenuate 5 ht induced reflex tachycardia

1991 • 8 citations