Elevations in cytosolic free Ca2+ are not required to trigger apoptosis in human leukaemia cells

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1972 • 15,349 citations

Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity

2012 • 8,865 citations

Cell Death: The Significance of Apoptosis

1980 • 7,281 citations

Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

1980 • 4,591 citations

Continuous growth and differentiation of human myeloid leukaemic cells in suspension culture

1977 • 2,134 citations

Macrophage phagocytosis of aging neutrophils in inflammation. Programmed cell death in the neutrophil leads to its recognition by macrophages.

1989 • 1,540 citations

Glucocorticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to cell death.

1984 • 1,441 citations

Dose‐dependent induction of apoptosis in human tumour cell lines by widely diverging stimuli

1991 • 816 citations

Endogenous endonuclease-induced DNA fragmentation: an early event in cell-mediated cytolysis.

1983 • 616 citations

Glucocorticoids activate a suicide process in thymocytes through an elevation of cytosolic Ca2+ concentration

1989 • 549 citations

Necrosis and apoptosis: distinct modes of cell death with fundamentally different significance.

1982 • 500 citations

Induction of apoptosis (programmed cell death) in human leukemic HL-60 cells by inhibition of RNA or protein synthesis.

1990 • 489 citations

2,3,7,8-Tetrachlorodibenzo- p -Dioxin Kills Immature Thymocytes by Ca ²⁺ -Mediated Endonuclease Activation

1988 • 460 citations

Macrophage recognition of cells undergoing programmed cell death (apoptosis).

1985 • 460 citations

Assessment of Fura-2 for measurements of cytosolic free calcium

1990 • 453 citations

Phagocytosis of senescent neutrophils by human monocyte-derived macrophages and rabbit inflammatory macrophages.

1982 • 326 citations

Calcium-dependent killing of immature thymocytes by stimulation via the CD3/T cell receptor complex.

1989 • 315 citations

Calcium-activated DNA Fragmentation in Rat Liver Nuclei

1989 • 281 citations

Programmed death of autoreactive thymocytes

1990 • 224 citations

IL-2 protects T lymphocytes from glucocorticoid-induced DNA fragmentation and cell death.

1989 • 158 citations

Ultraviolet B Irradiation of Human Leukaemia HL-60 Cellsin VitroInduces Apoptosis

1991 • 158 citations

Activation of internucleosomal DNA cleavage in human CEM lymphocytes by glucocorticoid and novobiocin. Evidence for a non-Ca2(+)-requiring mechanism(s).

1990 • 134 citations

Programmed cell death (apoptosis) in lymphoid and myeloid cell lines during zinc deficiency

1991 • 111 citations

Cytolysis by Ca-permeable transmembrane channels. Pore formation causes extensive DNA degradation and cell lysis.

1989 • 105 citations

T cell receptor-mediated DNA fragmentation and cell death in T cell hybridomas.

1990 • 98 citations

Cell ageing and cell death

1985 • 67 citations

Dexamethasone‐induced killing of neoplastic cells of lymphoid derivation: Lack of early calcium involvement

1990 • 47 citations

Quantal secretion and response lag demonstrated in single rat neutrophils

1985 • 11 citations

A versatile light microscope heating stage for biological temperatures

1986 • 10 citations