Initiation complex assembly at budding yeast replication origins begins with the recognition of a bipartite sequence by limiting amounts of the initiator, ORC.

Methods in Yeast Genetics

1988 • 4,905 citations

Improved method for high efficiency transformation of intact yeast cells

1992 • 3,258 citations

DNAase footprinting a simple method for the detection of protein-DNA binding specificity

1978 • 2,092 citations

ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complex

1992 • 1,279 citations

Isolation and characterisation of a yeast chromosomal replicator

1979 • 795 citations

Duplex opening by dnaA protein at novel sequences in initiation of replication at the origin of the E. coli chromosome

1988 • 678 citations

The dnaA protein complex with the E. coli chromosomal replication origin (oriC) and other DNA sites

1984 • 673 citations

A Yeast Chromosomal Origin of DNA Replication Defined by Multiple Functional Elements

1992 • 634 citations

Two steps in the assembly of complexes at yeast replication origins in vivo

1994 • 566 citations

A model for initiation at origins of DNA replication

1988 • 452 citations

The fission yeast cdc18+ gene product couples S phase to START and mitosis

1993 • 446 citations

Yeast Origin Recognition Complex Functions in Transcription Silencing and DNA Replication

1993 • 435 citations

[31] Tackling the protease problem in Saccharomyces cerevisiae

1991 • 427 citations

Isolation of ORC6 , a Component of the Yeast Origin Recognition Complex by a One-Hybrid System

1993 • 416 citations

Protein-DNA interactions at a yeast replication origin

1992 • 380 citations

Localization and Sequence Analysis of Yeast Origins of DNA Replication

1983 • 364 citations

A yeast silencer contains sequences that can promote autonomous plasmid replication and transcriptional activation

1987 • 332 citations

The acidic transcriptional activation domains of VP16 and p53 bind the cellular replication protein A and stimulate in vitro BPV-1 DNA replication

1993 • 329 citations

Origin Recognition Complex (ORC) in Transcriptional Silencing and DNA Replication in S. cerevisiae

1993 • 314 citations

Localized melting and structural changes in the SV40 origin of replication induced by T-antigen.

1988 • 268 citations

Cell Cycle Regulation of the Yeast Cdc7 Protein Kinase by Association With the Dbf4 Protein†

1993 • 250 citations

Purification of a yeast protein that binds to origins of DNA replication and a transcriptional silencer.

1988 • 234 citations

Yeast origin recognition complex is involved in DNA replication and transcriptional silencing

1993 • 231 citations

Structural requirements for the function of a yeast chromosomal replicator

1984 • 231 citations

Subcellular localization of yeast CDC46 varies with the cell cycle.

1990 • 226 citations

The transactivator proteins VP16 and GAL4 bind replication factor A

1993 • 216 citations

Interaction of Dbf4, the Cdc7 Protein Kinase Regulatory Subunit, with Yeast Replication Origins in Vivo

1994 • 213 citations

Deletion mutations affecting autonomously replicating sequence ARS1 of Saccharomyces cerevisiae.

1984 • 210 citations

A yeast replication origin consists of multiple copies of a small conserved sequence

1988 • 194 citations

Activation of Replication Origins within Yeast Chromosomes

1991 • 185 citations

DNA binding properties of an HMG1-related protein from yeast mitochondria.

1992 • 175 citations

Roles of two DNA-binding factors in replication, segregation and transcriptional repression mediated by a yeast silencer.

1988 • 174 citations

Mutational Analysis of the Consensus Sequence of a Replication Origin from Yeast Chromosome III

1990 • 174 citations

Functional conservation of multiple elements in yeast chromosomal replicators.

1994 • 145 citations

Addition of extra origins of replication to a minichromosome suppresses its mitotic loss in cdc6 and cdc14 mutants of Saccharomyces cerevisiae.

1992 • 145 citations

An Origin of DNA Replication and a Transcription Silencer Require a Common Element

1992 • 143 citations

Domain B of ARS307 contains two functional elements and contributes to chromosomal replication origin function.

1994 • 123 citations

Three domains in the simian virus 40 core origin orchestrate the binding, melting, and DNA helicase activities of T antigen

1990 • 122 citations

Fine-structure analysis of the DNA sequence requirements for autonomous replication of Saccharomyces cerevisiae plasmids.

1986 • 113 citations

The ARS consensus sequence is required for chromosomal origin function in Saccharomyces cerevisiae.

1992 • 111 citations

A DNA unwinding element and an ARS consensus comprise a replication origin within a yeast chromosome.

1993 • 108 citations

A synthetic silencer mediates SIR-dependent functions in Saccharomyces cerevisiae.

1991 • 105 citations

Initiation at Closely Spaced Replication Origins in a Yeast Chromosome

1993 • 104 citations

Temperature-sensitive cdc7 mutations of Saccharomyces cerevisiae are suppressed by the DBF4 gene, which is required for the G1/S cell cycle transition.

1992 • 103 citations

Replicator dominance in a eukaryotic chromosome.

1994 • 94 citations

Mutations in the HML E silencer of Saccharomyces cerevisiae yield metastable inheritance of transcriptional repression.

1991 • 92 citations

The dnaA Initiator Protein Binds Separate Domains in the Replication Origin of Escherichia coli

1989 • 89 citations

Deletion Mutations Affecting Autonomously Replicating Sequence ARS1 of Saccharomyces cerevisiae

1984 • 71 citations

Initiation preference at a yeast origin of replication.

1994 • 69 citations

Analysis of the interactions of functional domains of a nuclear origin of replication fromSaccharomyces cerevisiae

1991 • 65 citations

Recent developments in the initiation of chromosomal DNA replication: a complex picture emerges

1994 • 61 citations

Functional Conservation of Multiple Elements in Yeast Chromosomal Replicators

1994 • 54 citations

Fine-Structure Analysis of the DNA Sequence Requirements for Autonomous Replication of Saccharomyces cerevisiae Plasmids

1986 • 41 citations

Domain B of ARS307 Contains Two Functional Elements and Contributes to Chromosomal Replication Origin Function

1994 • 40 citations

The ARS Consensus Sequence Is Required for Chromosomal Origin Function in Saccharomyces cerevisiae

1992 • 38 citations

Interaction of the H4 autonomously replicating sequence core consensus sequence and its 3'-flanking domain.

1989 • 37 citations

A Synthetic Silencer Mediates SIR-Dependent Functions in Saccharomyces cerevisiae

1991 • 30 citations

Interaction of the H4 Autonomously Replicating Sequence Core Consensus Sequence and Its 3′-Flanking Domain

1989 • 22 citations

2 Chromosomal DNA Replication

1991 • 22 citations