The ras and myc oncogenes cooperate in tumor induction in many tissues when introduced into midgestation mouse embryos by retroviral vectors.

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

1983 • 2,871 citations

Construction of a retrovirus packaging mutant and its use to produce helper-free defective retrovirus

1983 • 1,857 citations

The Molecular Genetics of Cancer

1987 • 1,729 citations

Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture

1983 • 1,358 citations

Cellular Oncogenes and Multistep Carcinogenesis

1983 • 1,154 citations

Theory and Practice of Histotechnology

1981 • 1,106 citations

Detection of high incidence of K-ras oncogenes during human colon tumorigenesis

1987 • 1,074 citations

Coexpression of MMTV/v-Ha-ras and MMTV/c-myc genes in transgenic mice: Synergistic action of oncogenes in vivo

1987 • 796 citations

The molecular biology of tumor viruses

1974 • 734 citations

The Action of Oncogenes in the Cytoplasm and Nucleus

1985 • 708 citations

Clonal Analysis of Human Colorectal Tumors

1987 • 638 citations

De novo methylation and expression of retroviral genomes during mouse embryogenesis

1982 • 524 citations

Consequences of widespread deregulation of the c-myc gene in transgenic mice: Multiple neoplasms and normal development

1986 • 427 citations

Use of Restriction Fragment Length Polymorphisms to Determine the Clonal Origin of Human Tumors

1985 • 387 citations

Behavior of myc and ras oncogenes in transformation of rat embryo fibroblasts.

1986 • 272 citations

Pancreatic neoplasia induced by ras expression in acinar cells of transgenic mice

1987 • 271 citations

Ha-ras oncogene expression directed by a milk protein gene promoter: tissue specificity, hormonal regulation, and tumor induction in transgenic mice.

1987 • 228 citations

Regulated expression of a complete human beta-globin gene encoded by a transmissible retrovirus vector.

1987 • 153 citations

Retroviruses and embryogenesis: Microinjection of Moloney leukemia virus into midgestation mouse embryos

1980 • 149 citations

c-myc and c-fos expression in differentiating mouse primary keratinocytes.

1986 • 130 citations

Driven by the same Ig enhancer and SV40 T promoter ras induced lung adenomatous tumors, myc induced pre-B cell lymphomas and SV40 large T gene a variety of tumors in transgenic mice.

1987 • 129 citations

Malignant transformation of mouse primary keratinocytes by Harvey sarcoma virus and its modulation by surrounding normal cells.

1988 • 118 citations

Introduction of a selectable gene into different animal tissue by a retrovirus recombinant vector.

1984 • 88 citations

Retroviruses and Mouse Embryos: A Rapid Model for Neurovirulence and Transplacental Antiviral Therapy

1987 • 76 citations

Behavior of myc and ras Oncogenes in Transformation of Rat Embryo Fibroblasts

1986 • 67 citations

Tumorigenesis at a Predetermined Oral Site After One Intraperitoneal Injection of N -Nitroso- N -Methylurea

1982 • 42 citations

Oncogenes in transgenic mice

1988 • 38 citations

Regulated Expression of a Complete Human β-Globin Gene Encoded by a Transmissible Retrovirus Vector

1987 • 38 citations

Analysis of viral and somatic activations of the cHa-ras gene

1985 • 36 citations

Retroviral transduction of the human c-Ha-ras-1 oncogene into midgestation mouse embryos promotes rapid epithelial hyperplasia.

1989 • 26 citations

Retroviral Transduction of the Human c-Ha-ras-1 Oncogene into Midgestation Mouse Embryos Promotes Rapid Epithelial Hyperplasia

1989 • 5 citations