Conjugates of ursodeoxycholate protect against cholestasis and hepatocellular necrosis caused by more hydrophobic bile salts

IS URSODEOXYCHOLIC ACID AN EFFECTIVE TREATMENT FOR PRIMARY BILIARY CIRRHOSIS?

1987 • 532 citations

Re-evaluation of the 3 alpha-hydroxysteroid dehydrogenase assay for total bile acids in bile.

1978 • 524 citations

Quantitative estimation of the hydrophilic-hydrophobic balance of mixed bile salt solutions.

1989 • 523 citations

Ursodeoxycholic acid in primary biliary cirrhosis: Results of a controlled double-blind trial

1989 • 359 citations

Influence of Hydroxylation and Conjugation of Bile Salts on Their Membrane-Damaging Properties-Studies on Isolated Hepatocytes and Lipid Membrane Vesicles

1984 • 290 citations

Bile acid-induced liver toxicity: Relation to the hydrophobic-hydrophilic balance of bile acids

1986 • 271 citations

Mechanism of Cholestasis

1972 • 269 citations

Bile Acids, Liver Injury, and Liver Disease

1972 • 268 citations

Mechanism of Cholestasis

1972 • 209 citations

Enterohepatic circulation in the rat

1985 • 207 citations

Structural changes in membranes of large unilamellar vesicles after binding of sodium cholate

1986 • 195 citations

Gallstone dissolution with ursodeoxycholic acid in patients with chronic active hepatitis and two years follow-up

1985 • 174 citations

Perfusion of the Canine Colon with Unconjugated Bile Acids

1970 • 157 citations

Structural changes in vesicle membranes and mixed micelles of various lipid compositions after binding of different bile salts

1988 • 153 citations

Effect of Deoxycholic Acid Ingestion on Bile Acid Metabolism and Biliary Lipid Secretion in Normal Subjects

1977 • 138 citations

Effects of bile salts on the plasma membranes of isolated rat hepatocytes

1980 • 138 citations

Effect of Bile Salts on the Ionic Permeability of the Esophageal Mucosa and Their Role in the Production of Esophagitis

1975 • 122 citations

Acute effects of ursodeoxycholic and chenodeoxycholic acid on the small intestinal absorption of bile acids

1990 • 114 citations

Effects of ursodeoxycholic acid and taurine on serum liver enzymes and bile acids in chronic hepatitis

1990 • 106 citations

Tauroursodeoxycholate prevents taurocholate induced cholestasis

1982 • 105 citations

Tauroursodeoxycholate prevents biliary protein excretion induced by other bile salts in the rat

1985 • 103 citations

Bile acid metabolism in mammals. Ultrastructural studies on the intrahepatic cholestasis induced by lithocholic and chenodeoxycholic acids in the rat.

1971 • 102 citations

Studies on the Mechanism of Bile Salt-Induced Liposomal Membrane Damage

1983 • 84 citations

Effect of chenodeoxycholic and ursodeoxycholic acids on isolated adult human hepatocytes

1984 • 81 citations

Mechanism by which bile salt disrupts the gastric mucosal barrier in the dog.

1980 • 80 citations

BILE ACIDS

1957 • 75 citations

Regulation of bile acid synthesis. I. Effects of conjugated ursodeoxycholate and cholate on bile acid synthesis in chronic bile fistula rat

1988 • 73 citations

Bile Acid-Dependent Secretion of Alkaline Phosphatase in Rat Bile

2007 • 61 citations

Bile Acids

1964 • 60 citations

Liver cell membrane solubilization may control maximum secretory rate of cholic acid in the rat

1987 • 58 citations

Effect of taurochenodeoxycholate or tauroursodeoxycholate upon biliary output of phospholipids and plasma-membrane enzymes, and the extent of cell damage, in isolated perfused rat livers

1983 • 57 citations

Choleretic and cholestatic effects of infused bile salts in the rat

1979 • 56 citations

A Prospective Morphologic Evaluation of Hepatic Toxicity of Chenodeoxycholic Acid in Patients with Cholelithiasis: The National Cooperative Gallstone Study

1982 • 53 citations

Gallstone dissolution treatment with a combination of chenodeoxycholic and ursodeoxycholic acids

1986 • 52 citations

Effect of ursodeoxycholic acid treatment on alanine aminotransferase and γ-glutamyltranspeptidase serum levels in patients with hypertransaminasemia

1989 • 41 citations

Differing transport maxima values for taurine-conjugated bile salts in rats and hamsters

1986 • 32 citations

Glycoursodeoxycholate is as effective as tauroursodeoxycholate in preventing the taurocholate-induced cholestasis in the rat.

1983 • 23 citations

Effects of Detergents on Erythrocyte Membranes: Different Patterns of Solubilization of the Membrane Proteins by Dihydroxy and Trihydroxy Bile Salts

1975 • 20 citations

Lithocholic acid, cholestasis, and liver disease.

1972 • 18 citations

Interactions between different bile salts in the biliary excretion of the rat.

1983 • 13 citations

National cooperative gallstone study: Nonprimate toxicology of chenodeoxycholic acid

1982 • 12 citations

Mechanisms of liver adaptation to prolonged selective biliary obstruction (SBO) in the rat

1985 • 10 citations

Effects of Bile Salts on the Plasma Membranes of Isolated Hepatocytes

1979 • 8 citations

Effect of chenodeoxycholate feeding upon the biliary output of plasma membrane enzymes in the rat

1984 • 5 citations