Prognostic Significance of Stromal Platelet-Derived Growth Factor β-Receptor Expression in Human Breast Cancer

Fibroblasts in cancer

2006 • 4,177 citations

Tissue microarrays for high-throughput molecular profiling of tumor specimens

1998 • 4,104 citations

PDGFRA Activating Mutations in Gastrointestinal Stromal Tumors

2003 • 2,224 citations

Putting tumours in context

2001 • 2,145 citations

A Tyrosine Kinase Created by Fusion of thePDGFRAandFIP1L1Genes as a Therapeutic Target of Imatinib in Idiopathic Hypereosinophilic Syndrome

2003 • 1,683 citations

Stromal gene expression predicts clinical outcome in breast cancer

2008 • 1,633 citations

Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal

1999 • 1,248 citations

Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors

2003 • 1,236 citations

Fusion of PDGF receptor β to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation

1994 • 1,211 citations

Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors

2003 • 1,172 citations

PDGFRA Mutations in Gastrointestinal Stromal Tumors: Frequency, Spectrum and In Vitro Sensitivity to Imatinib

2005 • 809 citations

Response to Imatinib Mesylate in Patients with Chronic Myeloproliferative Diseases with Rearrangements of the Platelet-Derived Growth Factor Receptor Beta

2002 • 642 citations

Combined inhibition of VEGF‐ and PDGF‐signaling enforces tumor vessel regression by interfering with pericyte‐mediated endothelial cell survival mechanisms

2003 • 598 citations

A stroma-related gene signature predicts resistance to neoadjuvant chemotherapy in breast cancer

2009 • 592 citations

Therapeutic targeting of the tumor microenvironment

2005 • 543 citations

Endothelial and nonendothelial sources of PDGF-B regulate pericyte recruitment and influence vascular pattern formation in tumors

2003 • 481 citations

Inhibition of platelet-derived growth factor receptors reduces interstitial hypertension and increases transcapillary transport in tumors.

2001 • 444 citations

Endothelial and nonendothelial sources of PDGF-B regulate pericyte recruitment and influence vascular pattern formation in tumors

2003 • 436 citations

Inhibition of PDGF receptor signaling in tumor stroma enhances antitumor effect of chemotherapy.

2002 • 431 citations

Functions of Paracrine PDGF Signaling in the Proangiogenic Tumor Stroma Revealed by Pharmacological Targeting

2008 • 424 citations

Insight into the physiological functions of PDGF through genetic studies in mice

2004 • 401 citations

Peritumoral Fibroblast SPARC Expression and Patient Outcome With Resectable Pancreatic Adenocarcinoma

2007 • 388 citations

Amplification and/or overexpression of platelet-derived growth factor receptors and epidermal growth factor receptor in human glial tumors.

1992 • 380 citations

Platelet-Derived Growth Factor-B Enhances Glioma Angiogenesis by Stimulating Vascular Endothelial Growth Factor Expression in Tumor Endothelia and by Promoting Pericyte Recruitment

2003 • 340 citations

Stromal Myofibroblasts Predict Disease Recurrence for Colorectal Cancer

2007 • 337 citations

Intracranial inhibition of platelet-derived growth factor-mediated glioblastoma cell growth by an orally active kinase inhibitor of the 2-phenylaminopyrimidine class.

2000 • 312 citations

Abnormal gastrointestinal development in PDGF-A and PDGFR-α deficient mice implicates a novel mesenchymal structure with putative instructive properties in villus morphogenesis

2000 • 300 citations

Breast-Cancer Stromal Cells withTP53Mutations and Nodal Metastases

2007 • 293 citations

The dermatofibrosarcoma protuberans-associated collagen type Ialpha1/platelet-derived growth factor (PDGF) B-chain fusion gene generates a transforming protein that is processed to functional PDGF-BB.

1999 • 284 citations

Growth inhibition of dermatofibrosarcoma protuberans tumors by the platelet-derived growth factor receptor antagonist STI571 through induction of apoptosis.

2001 • 276 citations

Platelet-derived growth factor (PDGF) in oncogenesis: development of a vascular connective tissue stroma in xenotransplanted human melanoma producing PDGF-BB.

1993 • 238 citations

Tumorigenic conversion of immortal human keratinocytes through stromal cell activation

1998 • 236 citations

Paracrine Signaling by Platelet-Derived Growth Factor-CC Promotes Tumor Growth by Recruitment of Cancer-Associated Fibroblasts

2008 • 231 citations

PDGF Receptors as Targets in Tumor Treatment

2007 • 214 citations

Overexpression of platelet-derived growth factor receptor α in breast cancer is associated with tumour progression

2005 • 200 citations

Platelet-Derived Growth Factor Production by B16 Melanoma Cells Leads to Increased Pericyte Abundance in Tumors and an Associated Increase in Tumor Growth Rate

2004 • 196 citations

Analysis of Mural Cell Recruitment to Tumor Vessels

2002 • 181 citations

Systemic Stromal Effects of Estrogen Promote the Growth of Estrogen Receptor–Negative Cancers

2007 • 174 citations

Amplification of genes encoding KIT, PDGFRα and VEGFR2 receptor tyrosine kinases is frequent in glioblastoma multiforme

2005 • 152 citations

STI571 enhances the therapeutic index of epothilone B by a tumor-selective increase of drug uptake.

2003 • 142 citations

Low stroma androgen receptor level in normal and tumor prostate tissue is related to poor outcome in prostate cancer patients

2009 • 135 citations

PDGF‐a/PDGF alpha‐receptor signaling is required for lung growth and the formation of alveoli but not for early lung branching morphogenesis

2001 • 134 citations

Expression of platelet-derived growth factor B-chain and the platelet-derived growth factor receptor beta subunit in human breast tissue and breast carcinoma.

1995 • 125 citations

Inhibition of glioma cell growth by a truncated platelet-derived growth factor-beta receptor.

1994 • 116 citations

Genomic Instability Within Tumor Stroma and Clinicopathological Characteristics of Sporadic Primary Invasive Breast Carcinoma

2007 • 113 citations

Prognostic Impact of Platelet-Derived Growth Factors in Non-small Cell Lung Cancer Tumor and Stromal Cells

2008 • 108 citations

Direct Involvement of Breast Tumor Fibroblasts in the Modulation of Tamoxifen Sensitivity

2007 • 102 citations

Targeting the Expression of Platelet-Derived Growth Factor Receptor by Reactive Stroma Inhibits Growth and Metastasis of Human Colon Carcinoma

2006 • 102 citations

Microenvironmental Genomic Alterations and Clinicopathological Behavior in Head and Neck Squamous Cell Carcinoma

2007 • 97 citations

Characterization of an imatinib-sensitive subset of high-grade human glioma cultures

2006 • 96 citations

Imatinib mesylate (Gleevec®) in advanced breast cancer-expressing C-Kit or PDGFR-β: clinical activity and biological correlations

2008 • 93 citations

Expression of platelet-derived growth factor and activated receptor in clinical specimens of epithelial ovarian cancer and ovarian carcinoma cell lines

2004 • 85 citations

Localization of platelet-derived growth factor beta receptor expression in the periepithelial stroma of human breast carcinoma.

1996 • 83 citations

Platelet-derived growth factor A and B chains and the α and β receptors in prostatic intraepithelial neoplasia

1996 • 81 citations

Treatment with Imatinib in NSCLC is associated with decrease of phosphorylated PDGFR-β and VEGF expression, decrease in interstitial fluid pressure and improvement of oxygenation

2006 • 76 citations

Oestrogen receptors α and β show different associations to clinicopathological parameters and their co-expression might predict a better response to endocrine treatment in breast cancer

2008 • 65 citations

Effect of Platelet-Derived Growth Factor Receptor-β Inhibition with STI571 on Radioimmunotherapy

2005 • 65 citations

Platelet-derived growth factor receptor expression and amplification in choroid plexus carcinomas

2007 • 40 citations