Molecular pathogenesis of chronic myeloid leukemia: implications for new therapeutic strategies

Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr–Abl positive cells

1996 • 3,649 citations

SH2 domains recognize specific phosphopeptide sequences

1993 • 2,685 citations

Induction of Chronic Myelogenous Leukemia in Mice by the P210 ^bcr/abl Gene of the Philadelphia Chromosome

1990 • 2,207 citations

Mammalian Ras interacts directly with the serine/threonine kinase raf

1993 • 1,983 citations

Identification of a Ten-Amino Acid Proline-Rich SH3 Binding Site

1993 • 1,205 citations

Regulation, substrates and functions of src

1996 • 1,173 citations

Crystal structure of the Src family tyrosine kinase Hck

1997 • 1,165 citations

Structural organization of the bcr gene and its role in the Ph′ translocation

1985 • 920 citations

An alteration of the human c-abl protein in K562 leukemia cells unmasks associated tyrosine kinase activity

1984 • 913 citations

The Chronic Myelogenous Leukemia-Specific P210 Protein Is the Product of the bcr / abl Hybrid Gene

1986 • 820 citations

A novel viral oncogene with structural similarity to phospholipase C

1988 • 789 citations

Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro

1993 • 730 citations

Cytokine Signaling Through Nonreceptor Protein Tyrosine Kinases

1995 • 713 citations

Acute leukaemia in bcr/abl transgenic mice

1990 • 701 citations

A Cytoplasmic Inhibitor of the JNK Signal Transduction Pathway

1997 • 678 citations

BCR-ABL-induced oncogenesis is mediated by direct interaction with the SH2 domain of the GRB-2 adaptor protein

1993 • 667 citations

A novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent manner.

1994 • 653 citations

The Tyrosine Kinase Inhibitor CGP57148B Selectively Inhibits the Growth of BCR-ABL–Positive Cells

1997 • 646 citations

Ras recruits Raf-1 to the plasma membrane for activation by tyrosine phosphorylation.

1995 • 609 citations

Transformation of an interleukin 3-dependent hematopoietic cell line by the chronic myelogenous leukemia-specific P210bcr/abl protein.

1988 • 602 citations

Activation of the Sire-family tyrosine kinase Hck by SH3 domain displacement

1997 • 601 citations

Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway

1997 • 591 citations

Identification of a Protein that Binds to the SH3 Region of Abl and Is Similar to Bcr and GAP-rho

1992 • 553 citations

The ins and outs of Raf kinases

1994 • 537 citations

CGP 57148, a Tyrosine Kinase Inhibitor, Inhibits the Growth of Cells Expressing BCR-ABL, TEL-ABL, and TEL-PDGFR Fusion Proteins

1997 • 527 citations

Role of Phosphatidylinositol Kinase in PDGF Receptor Signal Transduction

1989 • 516 citations

Inhibition of apoptosis by BCR-ABL in chronic myeloid leukemia

1994 • 514 citations

Tyrosyl phosphorylation and DNA binding activity of signal transducers and activators of transcription (STAT) proteins in hematopoietic cell lines transformed by Bcr/Abl.

1996 • 501 citations

P210 and P190 Induce the Tyrosine Phosphorylation and DNA Binding Activity of Multiple Specific STAT Family Members

1996 • 498 citations

BCR-ABL maintains resistance of chronic myelogenous leukemia cells to apoptotic cell death [published erratum appears in Blood 1994 Jun 15;83(12):3835]

1994 • 495 citations

Bcr-Abl oncoproteins bind directly to activators of the Ras signalling pathway.

1994 • 454 citations

Constitutive activation of STAT5 by the BCR-ABL oncogene in chronic myelogenous leukemia.

1996 • 452 citations

Activation of Phosphatidylinositol-3′ Kinase by Src-Family Kinase SH3 Binding to the p85 Subunit

1994 • 437 citations

The mouse type IV c-abl gene product is a nuclear protein, and activation of transforming ability is associated with cytoplasmic localization

1989 • 427 citations

Function of Ras as a molecular switch in signal transduction.

1992 • 425 citations

A coiled-coil oligomerization domain of Bcr is essential for the transforming function of Bcr-Abl oncoproteins.

1993 • 423 citations

Phosphatidylinositol-3 kinase activity is regulated by BCR/ABL and is required for the growth of Philadelphia chromosome-positive cells

1995 • 419 citations

The Bcr-Abl leukemia oncogene activates Jun kinase and requires Jun for transformation.

1995 • 399 citations

How receptor tyrosine kinases activate ras

1993 • 393 citations

BCR first exon sequences specifically activate the BCR/ABL tyrosine kinase oncogene of Philadelphia chromosome-positive human leukemias.

1991 • 392 citations

In vitro transformation of immature hematopoietic cells by the P210 BCR/ABL oncogene product of the Philadelphia chromosome.

1987 • 380 citations

BCR sequences essential for transformation by the BCR-ABL oncogene bind to the ABL SH2 regulatory domain in a non-phosphotyrosine-dependent manner

1991 • 375 citations

bcr-abl, the hallmark of chronic myeloid leukaemia in man, induces multiple haemopoietic neoplasms in mice.

1990 • 371 citations

p62 : A Constitutively Tyrosine-Phosphorylated, GAP-Associated Protein in Chronic Myelogenous Leukemia Progenitor Cells

1997 • 371 citations

p130Cas, a Substrate Associated with v-Src and v-Crk, Localizes to Focal Adhesions and Binds to Focal Adhesion Kinase

1996 • 364 citations

Oligomerization of the ABL Tyrosine Kinase by the Ets Protein TEL in Human Leukemia

1996 • 349 citations

Integrin-mediated Cell Adhesion Promotes Tyrosine Phosphorylation of p130Cas, a Src Homology 3-containing Molecule Having Multiple Src Homology 2-binding Motifs

1995 • 340 citations

Interaction of phosphatidylinositol 3-kinase-associated p85 with epidermal growth factor and platelet-derived growth factor receptors.

1992 • 319 citations

An actin-binding function contributes to transformation by the Bcr-Abl oncoprotein of Philadelphia chromosome-positive human leukemias.

1993 • 317 citations

Myc but not Fos rescue of PDGF signalling block caused by kinase-inactive Src

1995 • 309 citations

Integrin regulation of c-Abl tyrosine kinase activity and cytoplasmic–nuclear transport

1996 • 309 citations

Alterations in the p53 gene and the clonal evolution of the blast crisis of chronic myelocytic leukemia.

1989 • 300 citations

Point mutations in the abl SH2 domain coordinately impair phosphotyrosine binding in vitro and transforming activity in vivo.

1992 • 295 citations

Crkl is the major tyrosine-phosphorylated protein in neutrophils from patients with chronic myelogenous leukemia.

1994 • 293 citations

The novel activation of ABL by fusion to an ets-related gene, TEL.

1995 • 289 citations

Evidence that SH2 domains promote processive phosphorylation by protein-tyrosine kinases

1995 • 288 citations

N-terminal mutations activate the leukemogenic potential of the myristoylated form of c-abl.

1989 • 288 citations

Activation of tyrosinase kinase and microfilament-binding functions of c-abl by bcr sequences in bcr/abl fusion proteins.

1991 • 286 citations

Structural and Signaling Requirements for BCR-ABL-Mediated Transformation and Inhibition of Apoptosis

1995 • 282 citations

Molecular Cloning Of Human Paxillin, a Focal Adhesion Protein Phosphorylated by P210BCR/ABL

1995 • 275 citations

Abi-2, a novel SH3-containing protein interacts with the c-Abl tyrosine kinase and modulates c-Abl transforming activity.

1995 • 273 citations

The BCR gene encodes a novel serine/threonine kinase activity within a single exon

1991 • 273 citations

The COOH terminus of the c-Abl tyrosine kinase contains distinct F- and G-actin binding domains with bundling activity [published erratum appears in J Cell Biol 1994 Mar;124(5):865]

1994 • 271 citations

Two species of human CRK cDNA encode proteins with distinct biological activities.

1992 • 269 citations

Genetic requirement for Ras in the transformation of fibroblasts and hematopoietic cells by the Bcr-Abl oncogene.

1995 • 268 citations

Alternative signals to RAS for hematopoietic transformation by the BCR-ABL oncogene

1995 • 261 citations

The proto-oncogene product p120CBL and the adaptor proteins CRKL and c-CRK link c-ABL, p190BCR/ABL and p210BCR/ABL to the phosphatidylinositol-3' kinase pathway.

1996 • 259 citations

The PAG gene product, a stress-induced protein with antioxidant properties, is an Abl SH3-binding protein and a physiological inhibitor of c-Abl tyrosine kinase activity

1997 • 258 citations

Control of the ERK MAP kinase cascade by Ras and Raf.

1996 • 249 citations

Bcl-2-independent Bcr–Abl-mediated resistance to apoptosis: protection is correlated with up regulation of Bcl-xL

1998 • 238 citations

The Bcr-Abl tyrosine kinase activates mitogenic signaling pathways and stimulates G1-to-S phase transition in hematopoietic cells

1997 • 228 citations

Activation of phosphatidylinositol 3-kinase in cells expressing abl oncogene variants.

1991 • 224 citations

BCR/ABL P210 and P190 cause distinct leukemia in transgenic mice

1995 • 224 citations

Interactions of Cbl with Grb2 and Phosphatidylinositol 3′-Kinase in Activated Jurkat Cells

1995 • 217 citations

Direct adhesion to bone marrow stroma via fibronectin receptors inhibits hematopoietic progenitor proliferation.

1995 • 216 citations

An intramolecular SH3-domain interaction regulates c-Abl activity

1998 • 215 citations

Deletion of an N-terminal regulatory domain of the c-abl tyrosine kinase activates its oncogenic potential.

1989 • 207 citations

Tumorigenic activity of the BCR-ABL oncogenes is mediated by BCL2.

1995 • 207 citations

Isolation and chromosomal localization of CRKL, a human crk-like gene.

1993 • 203 citations

Cell Cycle—Regulated Binding of c-Abl Tyrosine Kinase to DNA

1992 • 202 citations

Phosphatidylinositol kinase activity associates with viral p60src protein.

1989 • 194 citations

Differential Complementation of Bcr-Abl Point Mutants with c-Myc

1994 • 194 citations

Subcellular localization of Bcr, Abl, and Bcr-Abl proteins in normal and leukemic cells and correlation of expression with myeloid differentiation.

1993 • 190 citations

Tyrosine phosphorylation of CRKL in Philadelphia+ leukemia

1994 • 188 citations

Identification of CRKL as the constitutively phosphorylated 39-kD tyrosine phosphoprotein in chronic myelogenous leukemia cells

1994 • 187 citations

SH2 Domains of the p85α Subunit of Phosphatidylinositol 3-Kinase Regulate Binding to Growth Factor Receptors

1992 • 186 citations

Activation of Src kinases p53/56lyn and p59hck by p210bcr/abl in myeloid cells.

1996 • 185 citations

The BCR-ABL oncogene transforms Rat-1 cells and cooperates with v-myc.

1989 • 180 citations

The v-Src SH3 domain binds phosphatidylinositol 3'-kinase.

1993 • 180 citations

The Proto-oncogene Product c-Cbl Becomes Tyrosine Phosphorylated by Stimulation with GM-CSF or Epo and Constitutively Binds to the SH3 Domain of Grb2/Ash in Human Hematopoietic Cells

1995 • 179 citations

Specific phosphopeptide binding regulates a conformational change in the PI 3-kinase SH2 domain associated with enzyme activation.

1993 • 176 citations

Potential positive and negative autoregulation of p60c-src by intermolecular autophosphorylation.

1988 • 176 citations

Mutagenic analysis of the roles of SH2 and SH3 domains in regulation of the Abl tyrosine kinase.

1994 • 175 citations

BCR/ABL induces multiple abnormalities of cytoskeletal function.

1997 • 174 citations

Initiation of deregulated growth of multipotent progenitor cells by bcr-abl in vitro

1992 • 170 citations

The role of p21ras in receptor tyrosine kinase signaling

1995 • 166 citations

Increase of bcr-abl chimeric mRNA expression in tumor cells of patients with chronic myeloid leukemia precedes disease progression

1995 • 165 citations

Abr and Bcr are multifunctional regulators of the Rho GTP-binding protein family.

1995 • 162 citations

Control of ras activation.

1996 • 161 citations

Shc phosphorylation in myeloid cells is regulated by granulocyte macrophage colony-stimulating factor, interleukin-3, and steel factor and is constitutively increased by p210BCR/ABL.

1994 • 161 citations

Role of p21 RAS in p210 bcr-abl transformation of murine myeloid cells

1993 • 150 citations

Evidence for regulation of the human ABL tyrosine kinase by a cellular inhibitor.

1991 • 149 citations

Increased tyrosine phosphorylation of focal adhesion proteins in myeloid cell lines expressing p210BCR/ABL.

1995 • 148 citations

The BCR-ABL tyrosine kinase inhibits apoptosis by activating a Ras-dependent signaling pathway.

1996 • 146 citations

Tyrosine phosphorylation of p95Vav in myeloid cells is regulated by GM-CSF, IL-3 and steel factor and is constitutively increased by p210BCR/ABL.

1995 • 145 citations

The CRKL Adaptor Protein Transforms Fibroblasts and Functions in Transformation by the BCR-ABL Oncogene

1996 • 143 citations

Phosphatidylinositol 3-kinase is activated by nerve growth factor and epidermal growth factor in PC12 cells.

1992 • 142 citations

CRKL Links p210BCR/ABL with Paxillin in Chronic Myelogenous Leukemia Cells

1995 • 136 citations

Downstream of Crk adaptor signaling pathway: Activation of Jun kinase by v-Crk through the guanine nucleotide exchange protein C3G

1997 • 135 citations

p53 dependent growth suppression by the c-Abl nuclear tyrosine kinase.

1995 • 133 citations

Ras-Induced Activation of Raf-1 Is Dependent on Tyrosine Phosphorylation

1996 • 131 citations

Development of Acute Lymphoblastic Leukemia and Myeloproliferative Disorder in Transgenic Mice Expressing p210bcr/abl: A Novel Transgenic Model for Human Ph1-Positive Leukemias

1998 • 131 citations

Crkl Is Complexed with Tyrosine-phosphorylated Cbl in Ph-positive Leukemia

1995 • 129 citations

Molecular Cloning and Characterization of p56 Defines a New Family of RasGAP-binding Proteins

1998 • 128 citations

A bcr-v-abl oncogene induces lymphomas in transgenic mice.

1989 • 125 citations

The Src Family Kinase Hck Interacts with Bcr-Abl by a Kinase-independent Mechanism and Phosphorylates the Grb2-binding Site of Bcr

1997 • 124 citations

Secondary Mutation Maintains the Transformed State in BaF3 Cells With Inducible BCR/ABL Expression

1998 • 124 citations

A temperature sensitive p210 BCR-ABL mutant defines the primary consequences of BCR-ABL tyrosine kinase expression in growth factor dependent cells.

1994 • 117 citations

Cellular interactions of CRKL, and SH2-SH3 adaptor protein.

1994 • 116 citations

Expression and Function of Integrins on Hematopoietic Progenitor Cells

1997 • 116 citations

BCR – ABL activates pathways mediating cytokine independence and protection against apoptosis in murine hematopoietic cells in a dose-dependent manner

1998 • 116 citations

p130CAS Forms a Signaling Complex with the Adapter Protein CRKL in Hematopoietic Cells Transformed by the BCR/ABL Oncogene

1996 • 114 citations

4 Adhesion molecules in haemopoiesis

1997 • 101 citations

Direct Association of Grb2 with the p85 Subunit of Phosphatidylinositol 3-Kinase

1995 • 100 citations

Propagation of human blastic myeloid leukemias in the SCID mouse

1992 • 99 citations

Erythropoietin and Interleukin-3 Activate Tyrosine Phosphorylation of CBL and Association With CRK Adaptor Proteins

1997 • 97 citations

The stress activated protein kinase pathway.

1996 • 90 citations

SH2-containing phosphotyrosine phosphatase Syp is a target of p210bcr-abl tyrosine kinase.

1994 • 90 citations

The Dimerization Property of Glutathione -Transferase Partially Reactivates Bcr-Abl Lacking the Oligomerization Domain

1996 • 89 citations

ts BCR-ABL kinase activation confers increased resistance to genotoxic damage via cell cycle block.

1996 • 88 citations

Expression of p210bcr/abl by metallothionein promoter induced T-cell leukemia in transgenic mice

1995 • 88 citations

The Human Leukemia Oncogene bcr-abl Abrogates the Anchorage Requirement but Not the Growth Factor Requirement for Proliferation

1995 • 87 citations

Blastic transformation of p53-deficient bone marrow cells by p210 ^bcr/abl tyrosine kinase

1996 • 86 citations

Regulation of Bcl-2 gene expression by BCR-ABL is mediated by Ras

1997 • 86 citations

Tyrosine phosphorylation and activation of focal adhesion kinase (p125FAK) by BCR-ABL oncoprotein.

1995 • 85 citations

Cell adhesion in the stromal regulation of haemopoiesis

1992 • 84 citations

Direct Binding of CRKL to BCR-ABL Is Not Required for BCR-ABL Transformation

1997 • 83 citations

Apoptosis in chronic myeloid leukaemia: normal responses by progenitor cells to growth factor deprivation, X‐irradiation and glucocorticoids

1995 • 82 citations

Selective Transformation of Primitive Lymphoid Cells by the BCR/ABL Oncogene Expressed in Long-Term Lymphoid or Myeloid Cultures

1988 • 80 citations

A limited set of SH2 domains binds BCR through a high-affinity phosphotyrosine-independent interaction.

1992 • 78 citations

Mutant forms of growth factor-binding protein-2 reverse BCR-ABL-induced transformation.

1995 • 77 citations

The SH3 Domain Contributes to BCR/ABL-Dependent Leukemogenesis In Vivo: Role in Adhesion, Invasion, and Homing

1998 • 77 citations

The SH2 domain of P210BCR/ABL is not required for the transformation of hematopoietic factor-dependent cells

1995 • 75 citations

C-RAF-1 serine/threonine kinase is required in BCR/ABL-dependent and normal hematopoiesis.

1995 • 67 citations

Association of phosphatidylinositol 3-kinase with SHC in chronic myelogeneous leukemia cells.

1995 • 66 citations

Interactions of CBL with BCR-ABL and CRKL in BCR-ABL-transformed Myeloid Cells

1997 • 66 citations

PI 3-kinase activation in BCR/abl-transformed hematopoietic cells does not require interaction of p85 SH2 domains with p210 BCR/abl

1996 • 65 citations

Linkage of proliferative and maturational abnormalities in chronic myelogenous leukemia and relevance to treatment.

1993 • 62 citations

Interleukin-2 Stimulation Induces Tyrosine Phosphorylation of p120-Cbl and CrkL and Formation of Multimolecular Signaling Complexes in T Lymphocytes and Natural Killer Cells

1998 • 59 citations

Cell kinetics of leukemia.

1986 • 59 citations

Tyrosine phosphorylation of p120cbl in BCR/abl transformed hematopoietic cells mediates enhanced association with phosphatidylinositol 3-kinase

1997 • 58 citations

The study of phosphoinositide 3-kinase function.

1996 • 57 citations

P210 Bcr-Abl interacts with the interleukin 3 receptor beta(c) subunit and constitutively induces its tyrosine phosphorylation.

1996 • 57 citations

Regulation of the actin cytoskeleton, integrins and cell growth by the Rho family of small GTPases.

1996 • 56 citations

p210BCR/ABL induces formation of complexes containing focal adhesion proteins and the protooncogene product p120c-Cbl.

1996 • 55 citations

BCR – ABL accelerates C2-ceramide-induced apoptosis

1998 • 53 citations

Inhibition of Bcr Serine Kinase by Tyrosine Phosphorylation

1996 • 52 citations

Effect of Bcr sequences on the cellular function of the Bcr-Abl oncoprotein

1997 • 51 citations

BCR/ABL-induced Leukemogenesis Causes Phosphorylation of Hef1 and Its Association with Crkl

1997 • 51 citations

bcr/abl expression in 32D cl3(G) cells inhibits apoptosis induced by protein tyrosine kinase inhibitors.

1994 • 50 citations

Induction of Apoptosis by a Dominant Negative H-RAS Mutant (116Y) in K562 Cells

1994 • 49 citations

BCR/ABL confers growth factor independence upon a murine myeloid cell line.

1992 • 49 citations

Primary proliferating immature myeloid cells from CML patients are not resistant to induction of apoptosis by DNA damage and growth factor withdrawal

1996 • 47 citations

Monoclonal antibody crosslinking of the alpha 4 or beta 1 integrin inhibits committed clonogenic hematopoietic progenitor proliferation.

1997 • 46 citations

The BCR/ABL oncogene alters interaction of the adapter proteins CRKL and CRK with cellular proteins

1997 • 44 citations

Interaction of the receptor tyrosine kinase p145^c‐kit with the p210^bcr/abl kinase in myeloid cells

1996 • 44 citations

Pathophysiology of CML: Do defects in integrin function contribute to the premature circulation and massive expansion of the BCR/ABL positive clone?

1997 • 43 citations

c-ABL Tyrosine Kinase Activity Is Regulated by Association with a Novel SH3-Domain-Binding Protein

1996 • 41 citations

The Effect of Interferon-α on Beta-1 Integrin Mediated Adhesion and Growth Regulation in Chronic Myelogenous Leukemia

1998 • 41 citations

Mutation of a phenylalanine conserved in SH3-containing tyrosine kinases activates the transforming ability of c-Abl.

1993 • 37 citations

c-kit ligand stimulates tyrosine phosphorylation of the c-Cbl protein in human hematopoietic cells.

1996 • 36 citations

Potential molecules implicated in downstream signaling pathways of p185BCR-ABL in Ph+ ALL involve GTPase-activating protein, phospholipase C-gamma 1, and phosphatidylinositol 3'-kinase.

1994 • 33 citations

A Coiled-coil Tetramerization Domain of BCR-ABL Is Essential for the Interactions of SH2-containing Signal Transduction Molecules

1997 • 32 citations

The effect of bcr-abl antisense oligonucleotide on DNA synthesis and apoptosis in K562 chronic myeloid leukemia cells

1996 • 32 citations

Inhibition of Grb2 and Crkl Proteins Results in Growth Inhibition of Philadelphia Chromosome Positive Leukemic Cells

1997 • 29 citations

Analysis of human c-Abl tyrosine kinase activity and regulation in S. pombe.

1996 • 24 citations

P210 Bcr-Abl interacts with the interleukin-3 beta c subunit and constitutively activates Jak2.

1997 • 24 citations

Sequences within the first exon of BCR inhibit the activated tyrosine kinases of c-Abl and the Bcr-Abl oncoprotein.

1996 • 23 citations

Deletion of the ABL SH3 domain reactivates de‐oligomerized BCR‐ABL for growth factor independence

1996 • 21 citations

A role for Ras in v-Crk transformation.

1996 • 21 citations

Adhesive Defects in Chronic Myeloid Leukemia

1989 • 13 citations

INNOVATIVE THERAPY FOR CHRONIC MYELOGENOUS LEUKEMIA

1998 • 8 citations