Mutant forms of growth factor-binding protein-2 reverse BCR-ABL-induced transformation.

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 3,628 citations

Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome

1975 • 2,865 citations

Mammalian Ras interacts directly with the serine/threonine kinase raf

1993 • 1,983 citations

The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

1992 • 1,636 citations

An alteration of the human c-abl protein in K562 leukemia cells unmasks associated tyrosine kinase activity

1984 • 913 citations

Inhibition of NIH 3T3 Cell Proliferation by a Mutant ras Protein with Preferential Affinity for GDP

1988 • 757 citations

Induction of Membrane Ruffling and Fluid-Phase Pinocytosis in Quiescent Fibroblasts by ras Proteins

1986 • 725 citations

SH2 and SH3 domains

1993 • 697 citations

Differential transcriptional activation by Oct-1 and Oct-2: Interdependent activation domains induce Oct-2 phosphorylation

1990 • 696 citations

BCR-ABL-induced oncogenesis is mediated by direct interaction with the SH2 domain of the GRB-2 adaptor protein

1993 • 667 citations

C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains

1992 • 603 citations

Bcr-Abl oncoproteins bind directly to activators of the Ras signalling pathway.

1994 • 454 citations

Serum-, TPA-, and Ras-induced expression from Ap-1/Ets-driven promoters requires Raf-1 kinase.

1992 • 453 citations

Apoptosis (the 1992 Frank Rose Memorial Lecture)

1993 • 447 citations

How receptor tyrosine kinases activate ras

1993 • 393 citations

BCR first exon sequences specifically activate the BCR/ABL tyrosine kinase oncogene of Philadelphia chromosome-positive human leukemias.

1991 • 392 citations

C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins.

1994 • 391 citations

Signalling through SH2 and SH3 domains

1993 • 355 citations

Raf functions downstream of Rasl in the Sevenless signal transduction pathway

1992 • 323 citations

Structural and Signaling Requirements for BCR-ABL-Mediated Transformation and Inhibition of Apoptosis

1995 • 282 citations

C. elegans lin-45 raf gene participates in let-60 ras-stimulated vulval differentiation

1993 • 276 citations

Genetic requirement for Ras in the transformation of fibroblasts and hematopoietic cells by the Bcr-Abl oncogene.

1995 • 268 citations

Differential Complementation of Bcr-Abl Point Mutants with c-Myc

1994 • 194 citations

The BCR-ABL oncogene transforms Rat-1 cells and cooperates with v-myc.

1989 • 180 citations

the Viral and Cellular Forms of the Abelson (Dbl) Oncogene

1988 • 157 citations

Dynamin binds to SH3 domains of phospholipase C gamma and GRB-2.

1994 • 151 citations

Requirement for Raf and MAP kinase function during the meiotic maturation of Xenopus oocytes

1993 • 150 citations

Role of p21 RAS in p210 bcr-abl transformation of murine myeloid cells

1993 • 150 citations

Specific inhibition of cytoplasmic protein tyrosine kinases by herbimycin A in vitro

1991 • 139 citations

Tyrphostin-induced inhibition of p210bcr-abl tyrosine kinase activity induces K562 to differentiate

1993 • 133 citations

Binding of the Grb2 SH2 domain to phosphotyrosine motifs does not change the affinity of its SH3 domains for Sos proline-rich motifs.

1994 • 126 citations

A temperature sensitive p210 BCR-ABL mutant defines the primary consequences of BCR-ABL tyrosine kinase expression in growth factor dependent cells.

1994 • 117 citations

Expression of raf oncogenes activates the PEA1 transcription factor motif.

1989 • 101 citations

BCR First Exon Sequences Specifically Activate the BCR/ABL Tyrosine Kinase Oncogene of Philadelphia ChromosomePositive Human Leukemias

1991 • 97 citations

Cloning of a Grb2 Isoform with Apoptotic Properties

1994 • 91 citations

SH2-containing phosphotyrosine phosphatase Syp is a target of p210bcr-abl tyrosine kinase.

1994 • 90 citations

The Human Leukemia Oncogene bcr-abl Abrogates the Anchorage Requirement but Not the Growth Factor Requirement for Proliferation

1995 • 87 citations

SH3 domains of the adapter molecule Grb2 complex with two proteins in T cells: the guanine nucleotide exchange protein Sos and a 75-kDa protein that is a substrate for T cell antigen receptor-activated tyrosine kinases.

1994 • 85 citations

Expression of the normal p53 gene induces differentiation of K562 cells.

1992 • 83 citations

Growth factor-induced binding of dynamin to signal transduction proteins involves sorting to distinct and separate proline-rich dynamin sequences.

1994 • 81 citations

The BCR-ABL Oncogene Transforms Rat-1 Cells and Cooperates with v-myc

1989 • 50 citations

Expression of raf Oncogenes Activates the PEA1 Transcription Factor Motif

1989 • 27 citations