Interleukin-2 Stimulation Induces Tyrosine Phosphorylation of p120-Cbl and CrkL and Formation of Multimolecular Signaling Complexes in T Lymphocytes and Natural Killer Cells

SH2 domains recognize specific phosphopeptide sequences

1993 • 2,685 citations

Cloning of the γ Chain of the Human IL-2 Receptor

1992 • 835 citations

A novel viral oncogene with structural similarity to phospholipase C

1988 • 789 citations

Cytokine Signaling Through Nonreceptor Protein Tyrosine Kinases

1995 • 713 citations

Interaction of the IL-2 Receptor with thesrc-Family Kinase p56^lck: Identification of Novel Intermolecular Association

1991 • 576 citations

Protein kinase A phosphorylation of RhoA mediates the morphological and functional effects of cyclic AMP in cytotoxic lymphocytes.

1996 • 560 citations

Involvement of ras p21 protein in signal-transduction pathways from interleukin 2, interleukin 3, and granulocyte/macrophage colony-stimulating factor, but not from interleukin 4.

1991 • 351 citations

Characterization of a cell line, NKL, derived from an aggressive human natural killer cell leukemia.

1996 • 350 citations

v-cbl, an oncogene from a dual-recombinant murine retrovirus that induces early B-lineage lymphomas.

1989 • 316 citations

The protein product of the c-cbl protooncogene is the 120-kDa tyrosine-phosphorylated protein in Jurkat cells activated via the T cell antigen receptor.

1994 • 299 citations

c-Cbl is downstream of c-Src in a signalling pathway necessary for bone resorption

1996 • 285 citations

Two species of human CRK cDNA encode proteins with distinct biological activities.

1992 • 269 citations

The Product of the Proto-Oncogene c- cbl : A Negative Regulator of the Syk Tyrosine Kinase

1997 • 251 citations

Interleukin 2 and its receptors: recent advances and new immunological functions

1996 • 241 citations

The sequences of the human and mouse c-cbl proto-oncogenes show v-cbl was generated by a large truncation encompassing a proline-rich domain and a leucine zipper-like motif.

1991 • 234 citations

Tumour induction by activated abl involves tyrosine phosphorylation of the product of the cbl oncogene.

1994 • 232 citations

Activation of JAK kinases and STAT proteins by interleukin-2 and interferon alpha, but not the T cell antigen receptor, in human T lymphocytes.

1994 • 211 citations

Isolation and chromosomal localization of CRKL, a human crk-like gene.

1993 • 203 citations

Tyrosine Phosphorylation of the c-cbl Proto-oncogene Protein Product and Association with Epidermal Growth Factor (EGF) Receptor upon EGF Stimulation

1995 • 202 citations

The SH3 Domain-binding T Cell Tyrosyl Phosphoprotein p120

1995 • 186 citations

Stimulation through the T Cell Receptor Induces Cbl Association with Crk Proteins and the Guanine Nucleotide Exchange Protein C3G

1996 • 181 citations

The Proto-oncogene Product c-Cbl Becomes Tyrosine Phosphorylated by Stimulation with GM-CSF or Epo and Constitutively Binds to the SH3 Domain of Grb2/Ash in Human Hematopoietic Cells

1995 • 179 citations

Tyrosine Phosphorylation and Translocation of the c-Cbl Protein after Activation of Tyrosine Kinase Signaling Pathways

1995 • 171 citations

p120 Is a Major Substrate of Tyrosine Phosphorylation upon B Cell Antigen Receptor Stimulation and Interacts in Vivo with Fyn and Syk Tyrosine Kinases, Grb2 and Shc Adaptors, and the p85 Subunit of Phosphatidylinositol 3-Kinase

1996 • 170 citations

Tyrosine Phosphorylation of Cbl upon Epidermal Growth Factor (EGF) Stimulation and Its Association with EGF Receptor and Downstream Signaling Proteins

1996 • 166 citations

Interleukin-2 receptor regulates activation of phosphatidylinositol 3-kinase

1991 • 166 citations

Establishment of an interleukin 2-dependent human T cell line from a patient with T cell chronic lymphocytic leukemia who is not infected with human T cell leukemia/lymphoma virus

1987 • 165 citations

Protein tyrosine kinase syk is associated with and activated by the il-2 receptor: Possible link with the c-myc induction pathway

1995 • 164 citations

Insulin stimulates tyrosine phosphorylation of the proto-oncogene product of c-Cbl in 3T3-L1 adipocytes

1997 • 155 citations

The adapter protein Shc interacts with the interleukin-2 (IL-2) receptor upon IL-2 stimulation.

1994 • 149 citations

Physical association between Src homology 3 elements and the protein product of the c-cbl proto-oncogene

1994 • 148 citations

Interleukin-2 Triggers a Novel Phosphatidylinositol 3-Kinase-Dependent MEK Activation Pathway

1995 • 145 citations

p120 Is a Cytosolic Adapter Protein That Associates with Phosphoinositide 3-Kinase in Response to Epidermal Growth Factor in PC12 and Other Cells

1996 • 143 citations

Interactions of Cbl with Two Adaptor Proteins, Grb2 and Crk, upon T Cell Activation

1996 • 136 citations

Association of tyrosine protein kinase Zap-70 with the protooncogene product p120c-cbl in T lymphocytes.

1996 • 130 citations

IL-2 binding activates a tyrosine-phosphorylated phosphatidylinositol-3-kinase.

1991 • 126 citations

Binding of the Grb2 SH2 domain to phosphotyrosine motifs does not change the affinity of its SH3 domains for Sos proline-rich motifs.

1994 • 126 citations

Steel Factor Induces Tyrosine Phosphorylation of CRKL and Binding of CRKL to a Complex Containing c-Kit, Phosphatidylinositol 3-Kinase, and p120CBL

1997 • 123 citations

Phosphotyrosine Binding Domain-Dependent Upregulation of the Platelet-Derived Growth Factor Receptor α Signaling Cascade by Transforming Mutants of Cbl: Implications for Cbl’s Function and Oncogenicity

1997 • 119 citations

Sos, Vav, and C3G Participate in B Cell Receptor-induced Signaling Pathways and Differentially Associate with Shc-Grb2, Crk, and Crk-L Adaptors

1996 • 118 citations

Cellular interactions of CRKL, and SH2-SH3 adaptor protein.

1994 • 116 citations

The truncation that generated the v-cbl oncogene reveals an ability for nuclear transport, DNA binding and acute transformation.

1993 • 109 citations

Evidence for a role for the phosphotyrosine-binding domain of Shc in interleukin 2 signaling.

1996 • 108 citations

NMR structure of the N-terminal SH3 domain of GRB2 and its complex with a proline-rich peptide from Sos

1994 • 104 citations

Interleukin 2- and Polyomavirus Middle T Antigen-Induced Modification of Phosphatidylinositol 3-Kinase Activity in Activated T Lymphocytes

1991 • 98 citations

Interleukin-2-induced tyrosine phosphorylation of p52shc in T lymphocytes.

1993 • 98 citations

Specific Association of the β Isoform of the p85 Subunit of Phosphatidylinositol-3 Kinase with the Proto-oncogene c-cbl

1995 • 94 citations

Direct Binding of CRKL to BCR-ABL Is Not Required for BCR-ABL Transformation

1997 • 83 citations

Specific Association of Tyrosine-phosphorylated c-Cbl with Fyn Tyrosine Kinase in T Cells

1996 • 75 citations

Phosphorylation of Cbl following Stimulation with Interleukin-3 and Its Association with Grb2, Fyn, and Phosphatidylinositol 3-Kinase

1997 • 75 citations

Antisense Repression of Proto-oncogene c-Cbl Enhances Activation of the JAK-STAT Pathway but Not the Ras Pathway in Epidermal Growth Factor Receptor Signaling

1997 • 74 citations

Tyrosine Phosphorylation of the c-cbl Proto-oncogene Product Mediated by Cell Surface Antigen CD38 in HL-60 Cells

1996 • 67 citations

Interactions of CBL with BCR-ABL and CRKL in BCR-ABL-transformed Myeloid Cells

1997 • 66 citations

Ras-dependent, Ca2+-stimulated Activation of Nuclear Factor of Activated T Cells by a Constitutively Active Cbl Mutant in T Cells

1997 • 63 citations

Tyrosine-phosphorylated Cbl binds to Crk after T cell activation.

1996 • 60 citations

Interleukin 2- and polyomavirus middle T antigen-induced modification of phosphatidylinositol 3-kinase activity in activated T lymphocytes.

1991 • 58 citations

Specific association of phosphatidylinositol 3‐kinase with the protooncogene product Cbl in Fcγ receptor signaling

1996 • 44 citations

Association between phosphatidylinositol-3 kinase, Cbl and other tyrosine phosphorylated proteins in colony-stimulating factor-1-stimulated macrophages

1996 • 41 citations

Direct T Cell Activation by Chimeric Single Chain Fv-Syk Promotes Syk-Cbl Association and Cbl Phosphorylation

1997 • 34 citations