The human ATP-binding cassette (ABC) transporter superfamily

The neighbor-joining method: a new method for reconstructing phylogenetic trees.

1987 • 59,130 citations

Initial sequencing and analysis of the human genome

2001 • 23,520 citations

The Sequence of the Human Genome

2001 • 13,500 citations

The rapid generation of mutation data matrices from protein sequences

1992 • 6,766 citations

ABC Transporters: From Microorganisms to Man

1992 • 3,956 citations

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

1976 • 3,228 citations

Overexpression of a Transporter Gene in a Multidrug-Resistant Human Lung Cancer Cell Line

1992 • 3,039 citations

Evolutionary Divergence and Convergence in Proteins

1965 • 2,780 citations

Functional polymorphisms of the human multidrug-resistance gene: Multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo

2000 • 2,358 citations

A multidrug resistance transporter from human MCF-7 breast cancer cells

1998 • 2,273 citations

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells

1986 • 1,903 citations

The common PPARγ Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes

2000 • 1,770 citations

A Family of Drug Transporters: the Multidrug Resistance-Associated Proteins

2000 • 1,723 citations

The Human ATP-Binding Cassette (ABC) Transporter Superfamily

2001 • 1,705 citations

Accumulation of Dietary Cholesterol in Sitosterolemia Caused by Mutations in Adjacent ABC Transporters

2000 • 1,626 citations

Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRα and LXRβ

2000 • 1,619 citations

A Whole-Genome Assembly of Drosophila

2000 • 1,532 citations

Pathophysiologic Implications of Membrane Phospholipid Asymmetry in Blood Cells

1997 • 1,321 citations

A PPARγ-LXR-ABCA1 Pathway in Macrophages Is Involved in Cholesterol Efflux and Atherogenesis

2001 • 1,287 citations

How Cells Handle Cholesterol

2000 • 1,230 citations

Putative X-linked adrenoleukodystrophy gene shares unexpected homology with ABC transporters

1993 • 1,175 citations

Structural model of ATP-binding proteing associated with cystic fibrosis, multidrug resistance and bacterial transport

1990 • 1,149 citations

PPAR-γ dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation

2001 • 1,062 citations

The asymmetric distribution of phospholipids in the human red cell membrane. A combined study using phospholipases and freeze-etch electron microscopy

1973 • 1,052 citations

Sphingolipid–Cholesterol Rafts Diffuse as Small Entities in the Plasma Membrane of Mammalian Cells

2000 • 987 citations

A gene encoding a liver-specific ABC transporter is mutated in progressive familial intrahepatic cholestasis

1998 • 980 citations

Relation between Mutations of the Cystic Fibrosis Gene and Idiopathic Pancreatitis

1998 • 923 citations

MDR1 P-Glycoprotein Is a Lipid Translocase of Broad Specificity, While MDR3 P-Glycoprotein Specifically Translocates Phosphatidylcholine

1996 • 863 citations

Insights into the Function of Rim Protein in Photoreceptors and Etiology of Stargardt's Disease from the Phenotype in abcr Knockout Mice

1999 • 854 citations

Phospholipids in animal eukaryotic membranes: transverse asymmetry and movement

1993 • 831 citations

Congenital Jaundice in Rats with a Mutation in a Multidrug Resistance-Associated Protein Gene

1996 • 827 citations

Mutations in the Sulfonylurea Receptor Gene in Familial Persistent Hyperinsulinemic Hypoglycemia of Infancy

1995 • 812 citations

Molecular cloning of cDNAs which are highly overexpressed in mitoxantrone-resistant cells: demonstration of homology to ABC transport genes.

1999 • 810 citations

A human placenta-specific ATP-binding cassette gene (ABCP) on chromosome 4q22 that is involved in multidrug resistance.

1998 • 798 citations

Evolution by the birth-and-death process in multigene families of the vertebrate immune system

1997 • 793 citations

Mutations in the MDR 3 gene cause progressive familial intrahepatic cholestasis

1998 • 718 citations

Identification of a gene, ABCG5, important in the regulation of dietary cholesterol absorption

2001 • 683 citations

Crystal structure of the ATP-binding subunit of an ABC transporter

1998 • 659 citations

Asymmetrical Lipid Bilayer Structure for Biological Membranes

1972 • 606 citations

Sex-linked inheritance in Drosophila

1916 • 605 citations

Phosphatidylcholine translocase: A physiological role for the mdr2 gene

1994 • 600 citations

An inventory of the human ABC proteins

1999 • 587 citations

Sex Limited Inheritance in Drosophila

1910 • 561 citations

ABCG1 (ABC8), the human homolog of the Drosophila white gene, is a regulator of macrophage cholesterol and phospholipid transport

2000 • 540 citations

Mutations in a gene encoding an ABC transporter cause pseudoxanthoma elasticum

2000 • 531 citations

ABC1 promotes engulfment of apoptotic cells and transbilayer redistribution of phosphatidylserine.

2000 • 529 citations

Pfam 3.1: 1313 multiple alignments and profile HMMs match the majority of proteins

1999 • 511 citations

Molecular Cloning of the Human ATP-Binding Cassette Transporter 1 (hABC1): Evidence for Sterol-Dependent Regulation in Macrophages

1999 • 502 citations

ABCA1: the gatekeeper for eliminating excess tissue cholesterol

2001 • 460 citations

The Leukotriene C4 Transporter MRP1 Regulates CCL19 (MIP-3β, ELC)–Dependent Mobilization of Dendritic Cells to Lymph Nodes

2000 • 456 citations

Complete inventory of the yeast ABC proteins

1997 • 455 citations

Lipid translocation across the plasma membrane of mammalian cells

1999 • 437 citations

Multiple alignment using hidden Markov models.

1995 • 425 citations

Intracellular cholesterol transport

1999 • 416 citations

Mutation of a Putative Mitochondrial Iron Transporter Gene (ABC7) in X-Linked Sideroblastic Anemia and Ataxia (XLSA/A)

1999 • 406 citations

Physiological Basis of Cystic Fibrosis: A Historical Perspective

1999 • 400 citations

Human White/Murine ABC8 mRNA Levels Are Highly Induced in Lipid-loaded Macrophages

2000 • 386 citations

A yeast metal resistance protein similar to human cystic fibrosis transmembrane conductance regulator (CFTR) and multidrug resistance-associated protein.

1994 • 364 citations

Mutations in the ABC 1 gene in familial HDL deficiency with defective cholesterol efflux

1999 • 358 citations

Multiple mutations in highly conserved residues are found in mildly affected cystic fibrosis patients

1990 • 353 citations

Retinal Stimulates ATP Hydrolysis by Purified and Reconstituted ABCR, the Photoreceptor-specific ATP-binding Cassette Transporter Responsible for Stargardt Disease

1999 • 351 citations

Structure of the Multidrug Resistance P-glycoprotein to 2.5 nm Resolution Determined by Electron Microscopy and Image Analysis

1997 • 341 citations

Salmonella typhi uses CFTR to enter intestinal epithelial cells

1998 • 340 citations

Selectivity of MHC-encoded peptide transporters from human, mouse and rat

1994 • 339 citations

Heterozygous MDR3 missense mutation associated with intrahepatic cholestasis of pregnancy: evidence for a defect in protein trafficking

2000 • 307 citations

ABC transporters in lipid transport

2000 • 300 citations

CFTR and outward rectifying chloride channels are distinct proteins with a regulatory relationship

1993 • 298 citations

The 220-kDa Rim Protein of Retinal Rod Outer Segments Is a Member of the ABC Transporter Superfamily

1997 • 297 citations

Defect of multidrug-resistance 3 gene expression in a subtype of progressive familial intrahepatic cholestasis

1996 • 291 citations

The ABC transporter Atm1p is required for mitochondrial iron homeostasis

1997 • 278 citations

Cloning of Two Novel ABC Transporters Mapping on Human Chromosome 9

1994 • 262 citations

Mutations in the canilicular multispecific organic anion transporter (cMOAT) gene, a novel ABC transporter, in patients with hyperbilirubinemia II/Dubin-Johnson syndrome

1998 • 259 citations

Role of ABCG1 and other ABCG family members in lipid metabolism

2001 • 256 citations

Evolution of ATP-binding cassette transporter genes

1995 • 249 citations

Identification of a sister gene to P-glycoprotein.

1995 • 236 citations

Evidence that GCN1 and GCN20, Translational Regulators of GCN4, Function on Elongating Ribosomes in Activation of eIF2α Kinase GCN2

1997 • 209 citations

Complete genomic sequence of the human ABCA1 gene: Analysis of the human and mouse ATP-binding cassette A promoter

2000 • 206 citations

Increased incidence of cystic fibrosis gene mutations in adults with disseminated bronchiectasis

1995 • 189 citations

The Product of the ABC Half-Transporter Gene ABCG2 (BCRP/MXR/ABCP) Is Expressed in the Plasma Membrane

2000 • 184 citations

The photoreceptor rim protein is an ABC transporter encoded by the gene for recessive Stargardt's disease (ABCR)

1997 • 164 citations

Identification of a Novel Human Sterol-Sensitive ATP-Binding Cassette Transporter (ABCA7)

2000 • 157 citations

Cell Membrane Lipid Composition and Distribution: Implications for Cell Function and Lessons Learned From Photoreceptors and Platelets

1997 • 156 citations

Regulation and intracellular trafficking of the ABCA1 transporter

2001 • 156 citations

Flip-flop: The transmembrane translocation of lipids

1994 • 144 citations

Transmembrane Organization of Mouse P-glycoprotein Determined by Epitope Insertion and Immunofluorescence

1996 • 142 citations

The MDR superfamily of genes and its biological implications.

1994 • 140 citations

Evidence for an alternate model of human P-glycoprotein structure and biogenesis.

1993 • 138 citations

ABC50 Interacts with Eukaryotic Initiation Factor 2 and Associates with the Ribosome in an ATP-dependent Manner

2000 • 133 citations

Study of membrane orientation and glycosylated extracellular loops of mouse P-glycoprotein by in vitro translation.

1991 • 132 citations

Histologic Pathology of the Liver in Progressive Familial Intrahepatic Cholestasis

1994 • 129 citations

Simple and Complex ABCR: Genetic Predisposition to Retinal Disease

2000 • 127 citations

Interactions between metabolism and intracellular distribution of cholesterol and sphingomyelin

2000 • 127 citations

ATP-binding Cassette Transporter A1 Contains an NH2-terminal Signal Anchor Sequence That Translocates the Protein's First Hydrophilic Domain to the Exoplasmic Space

2001 • 119 citations

Isolation and characterization of Drosophila multidrug resistance gene homologs.

1991 • 118 citations

The ABCA subclass of mammalian transporters

1999 • 116 citations

STE6, the yeast a-factor transporter

1993 • 114 citations

Characterization of the amino-terminal regions in the human multidrug resistance protein (MRP1)

2000 • 113 citations

Lipid Traffic: The ABC of Transbilayer Movement

2000 • 109 citations

Cloning of the cDNA for a human homologue of the Drosophila white gene and mapping to chromosome 21q22.3.

1996 • 106 citations

The four murine peroxisomal ABC‐transporter genes differ in constitutive, inducible and developmental expression

1999 • 101 citations

Changes in lipid and protein constituents of rafts and caveolae in multidrug resistant cancer cells and their functional consequences.

2000 • 100 citations

Complete Coding Sequence, Promoter Region, and Genomic Structure of the Human ABCA2 Gene and Evidence for Sterol-Dependent Regulation in Macrophages

2001 • 87 citations

Membrane topology of the N-terminal half of the hamster P-glycoprotein molecule

1993 • 82 citations

A leptomycin B resistance gene of Schizosaccharomyces pombe encodes a protein similar to the mammalian P‐glycoproteins

1992 • 79 citations

ATP-Binding Cassette Transporter ABC2/ABCA2 in the Rat Brain: A Novel Mammalian Lysosome-Associated Membrane Protein and a Specific Marker for Oligodendrocytes But Not for Myelin Sheaths

2001 • 75 citations

Genomic Sequence and Structure of the Human ABCG1 (ABC8) Gene

2001 • 70 citations

Analysis of hABC1 Gene 5′ End: Additional Peptide Sequence, Promoter Region, and Four Polymorphisms

2000 • 68 citations

Multidrug resistance: a role for cholesterol efflux pathways?

2000 • 67 citations

Sequence Comparison of Yeast ATP-binding Cassette Proteins

1995 • 65 citations

Association of a variant in exon 31 of the sulfonylurea receptor 1 (SUR1) gene with type 2 diabetes mellitus in French Caucasians

2000 • 61 citations

Variant in sulfonylurea receptor-1 gene is associated with high insulin concentrations in non-diabetic Mexican Americans: SUR-1 gene variant and hyperinsulinemia

1998 • 52 citations

Comparative analysis of the promoter structure and genomic organization of the human and mouse ABCA7 gene encoding a novel ABCA transporter

2001 • 45 citations

Fenofibrate differently alters expression of genes encoding ATP‐binding transporter proteins of the peroxisomal membrane

1997 • 38 citations

[56] Peroxisomal ABC transporters

1998 • 36 citations

An ATP-binding cassette gene (ABCG3) closely related to the multidrug transporter ABCG2 (MXR/ABCP) has an unusual ATP-binding domain

2001 • 36 citations

Characterization of the Adrenoleukodystrophy-Related (ALDR, ABCD2) Gene Promoter: Inductibility by Retinoic Acid and Forskolin

2000 • 23 citations

P-Glycoprotein: To flip or not to flip?

1994 • 17 citations

SEX-LIMITED INHERITANCE

1910 • 14 citations

[19] Topology of P-glycoproteins

1998 • 11 citations

Sitosterolemia

1997 • 8 citations