An RNA-binding protein specifically interacts with a functionally important domain of the downstream element of the simian virus 40 late polyadenylation signal.

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

Transcriptional Regulation in Mammalian Cells by Sequence-Specific DNA Binding Proteins

1989 • 3,219 citations

The consensus sequence YGTGTTYY located downstream from the AATAAA signal is required for efficient formation of mRNA 3′ termini

1985 • 652 citations

Point mutations in AAUAAA and the poly (A) addition site: effects on the accuracy and efficiency of cleavage and polyadenylationin vitro

1990 • 498 citations

COMPLEX TRANSCRIPTIONAL UNITS: DIVERSITY IN GENE EXPRESSION BY ALTERNATIVE RNA PROCESSING

1986 • 486 citations

Poly(A) signals

1991 • 438 citations

Immunopurification of heterogeneous nuclear ribonucleoprotein particles reveals an assortment of RNA-binding proteins.

1988 • 399 citations

How the messenger got its tail: addition of poly(A) in the nucleus

1990 • 390 citations

Photochemistry and Photobiology of Nucleic Acids

1976 • 374 citations

Accurate cleavage and polyadenylation of exogenous RNA substrate

1985 • 334 citations

Reactions at the termini of tRNA with T4 RNA ligase

1978 • 325 citations

In vitro polyadenylation is stimulated by the presence of an upstream intron.

1990 • 313 citations

Requirement of a downstream sequence for generation of a poly(A) addition site

1984 • 261 citations

A poly(A) addition site and a downstream termination region are required for efficient cessation of transcription by RNA polymerase II in the mouse beta maj-globin gene.

1987 • 247 citations

A multisubunit factor, CstF, is required for polyadenylation of mammalian pre-mRNAs.

1990 • 243 citations

Structure and Function of Nuclear and Cytoplasmic Ribonucleoprotein Particles

1986 • 243 citations

Alpha-thalassaemia caused by a poly(A) site mutation reveals that transcriptional termination is linked to 3′ end processing in the human alpha 2 globin gene.

1986 • 236 citations

Position-dependent sequence elements downstream of AAUAAA are required for efficient rabbit β-globin mRNA 3′ end formation

1987 • 229 citations

Four factors are required for 3'-end cleavage of pre-mRNAs.

1989 • 217 citations

Polyadenylation of mRNA precursors

1988 • 210 citations

3′ cleavage and polyadenylation of mRNA precursors in vitro requires a poly(A) polymerase, a cleavage factor, and a snRNP

1988 • 205 citations

Efficiency of Utilization of the Simian Virus 40 Late Polyadenylation Site: Effects of Upstream Sequences

1989 • 205 citations

An ordered pathway of assembly of components required for polyadenylation site recognition and processing.

1989 • 194 citations

A 64 kd nuclear protein binds to RNA segments that include the AAUAAA polyadenylation motif

1988 • 187 citations

Sequences capable of restoring poly(A) site function define two distinct downstream elements.

1986 • 175 citations

Sequences 5' to the polyadenylation signal mediate differential poly(A) site use in hepatitis B viruses.

1990 • 159 citations

Poly(A) site cleavage in a HeLa nuclear extract is dependent on downstream sequences

1985 • 152 citations

A sequence downstream of A-A-U-A-A-A is required for formation of simian virus 40 late mRNA 3' termini in frog oocytes.

1985 • 139 citations

The human immunodeficiency virus type 1 polyadenylylation signal: a 3' long terminal repeat element upstream of the AAUAAA necessary for efficient polyadenylylation.

1991 • 136 citations

Envelope sequences of two new United States HIV-1 isolates

1988 • 125 citations

Sequences on the 3' side of hexanucleotide AAUAAA affect efficiency of cleavage at the polyadenylation site.

1984 • 113 citations

Sequences upstream of AAUAAA influence poly(A) site selection in a complex transcription unit.

1989 • 108 citations

A Uridylate Tract Mediates Efficient Heterogeneous Nuclear Ribonucleoprotein C Protein-RNA Cross-Linking and Functionally Substitutes for the Downstream Element of the Polyadenylation Signal

1990 • 107 citations

Identification of a sequence element on the 3' side of AAUAAA which is necessary for simian virus 40 late mRNA 3'-end processing.

1985 • 105 citations

The core proteins of 35 S hnRNP complexes

1985 • 101 citations

Efficiency of utilization of the simian virus 40 late polyadenylation site: effects of upstream sequences.

1989 • 91 citations

Functional analysis of point mutations in the AAUAAA motif of the SV40 late polyadenylation signal

1989 • 89 citations

The Radiation-Induced Addition of Proteins and Other Molecules to Nucleic Acids

1976 • 88 citations

Cleavage and polyadenylation of messenger RNA precursors in vitro occurs within large and specific 3′ processing complexes.

1987 • 88 citations

Poly(A) site choice rather than splice site choice governs the regulated production of IgM heavy-chain RNAs.

1988 • 87 citations

The C proteins of heterogeneous nuclear ribonucleoprotein complexes interact with RNA sequences downstream of polyadenylation cleavage sites.

1988 • 86 citations

Herpes simplex virus induces a processing factor that stimulates poly(A) site usage

1989 • 84 citations

Involvement of long terminal repeat U3 sequences overlapping the transcription control region in human immunodeficiency virus type 1 mRNA 3' end formation.

1991 • 79 citations

Sequences on the 3′ Side of Hexanucleotide AAUAAA Affect Efficiency of Cleavage at the Polyadenylation Site

1984 • 72 citations

Occlusion of the HIV poly(A) site.

1991 • 68 citations

A functionally redundant downstream sequence in SV40 late pre-mRNA is required for mRNA 3'-end formation and for assembly of a precleavage complex in vitro.

1988 • 64 citations

Regulation of poly(A) site selection in adenovirus

1989 • 61 citations

Sequences Downstream of AAUAAA Signals Affect Pre-mRNA Cleavage and Polyadenylation In Vitro Both Directly and Indirectly

1989 • 61 citations

Identification of sequences in the herpes simplex virus thymidine kinase gene required for efficient processing and polyadenylation.

1985 • 60 citations

Identification of a Sequence Element on the 3′ Side of AAUAAA Which Is Necessary for Simian Virus 40 Late mRNA 3′-End Processing

1985 • 59 citations

Identification of a complex associated with processing and polyadenylation in vitro of herpes simplex virus type 1 thymidine kinase precursor RNA.

1987 • 59 citations

Specific pre-cleavage and post-cleavage complexes involved in the formation of SV40 late mRNA 3′ termini in vitro.

1987 • 57 citations

Sequences Upstream of AAUAAA Influence Poly(A) Site Selection in a Complex Transcription Unit

1989 • 54 citations

Involvement of Long Terminal Repeat U3 Sequences Overlapping the Transcription Control Region in Human Immunodeficiency Virus Type 1 mRNA 3′ End Formation

1991 • 43 citations

Sedimentation analysis of polyadenylation-specific complexes.

1988 • 42 citations

Identification of Sequences in the Herpes Simplex Virus Thymidine Kinase Gene Required for Efficient Processing and Polyadenylation

1985 • 41 citations

A uridylate tract mediates efficient heterogeneous nuclear ribonucleoprotein C protein-RNA cross-linking and functionally substitutes for the downstream element of the polyadenylation signal.

1990 • 40 citations

Polyadenylation of mRNA: minimal substrates and a requirement for the 2' hydroxyl of the U in AAUAAA.

1990 • 35 citations

Assembly of a polyadenylation-specific 25S ribonucleoprotein complex in vitro.

1988 • 35 citations

Sequences downstream of AAUAAA signals affect pre-mRNA cleavage and polyadenylation in vitro both directly and indirectly.

1989 • 23 citations

Sedimentation Analysis of Polyadenylation-Specific Complexes

1988 • 22 citations

Assembly of a Polyadenylation-Specific 25S Ribonucleoprotein Complex In Vitro

1988 • 20 citations

Polyadenylation of mRNA: Minimal Substrates and a Requirement for the 2′ Hydroxyl of the U in AAUAAA

1990 • 12 citations

Structure and Function of Nuclear and Cytoplasmic Ribonucleoprotein Particles

1986 • 4 citations