Molecular Bases for the Recognition of Tyrosine-based Sorting Signals

ENDOCYTOSIS AND MOLECULAR SORTING

1996 • 1,537 citations

Interaction of Tyrosine-Based Sorting Signals with Clathrin-Associated Proteins

1995 • 955 citations

NPXY, a sequence often found in cytoplasmic tails, is required for coated pit-mediated internalization of the low density lipoprotein receptor.

1990 • 944 citations

Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: Crystal structures of the complexed and peptide-free forms

1993 • 758 citations

Altered Trafficking of Lysosomal Proteins in Hermansky-Pudlak Syndrome Due to Mutations in the β3A Subunit of the AP-3 Adaptor

1999 • 663 citations

A Structural Explanation for the Recognition of Tyrosine-Based Endocytotic Signals

1998 • 582 citations

A novel di-leucine motif and a tyrosine-based motif independently mediate lysosomal targeting and endocytosis of CD3 chains

1992 • 540 citations

Transferrin receptor internalization sequence YXRF implicates a tight turn as the structural recognition motif for endocytosis

1990 • 508 citations

Linking cargo to vesicle formation: receptor tail interactions with coat proteins

1997 • 408 citations

AP-3: an adaptor-like protein complex with ubiquitous expression

1997 • 389 citations

Association of the AP-3 Adaptor Complex with Clathrin

1998 • 384 citations

Characterization of the Adaptor-related Protein Complex, AP-3

1997 • 369 citations

Specificity of binding of clathrin adaptors to signals on the mannose-6-phosphate/insulin-like growth factor II receptor.

1989 • 336 citations

Tyrosine Phosphorylation Controls Internalization of CTLA-4 by Regulating Its Interaction with Clathrin-Associated Adaptor Complex AP-2

1997 • 334 citations

Protein sorting by tyrosine-based signals: adapting to the Ys and wherefores

1997 • 329 citations

Protein targeting by tyrosine- and di-leucine-based signals: evidence for distinct saturable components.

1996 • 314 citations

Dileucine-based sorting signals bind to the beta chain of AP-1 at a site distinct and regulated differently from the tyrosine-based motif-binding site

1998 • 310 citations

Structural Determinants of Interaction of Tyrosine-based Sorting Signals with the Adaptor Medium Chains

1996 • 294 citations

AP-4, a Novel Protein Complex Related to Clathrin Adaptors

1999 • 292 citations

A mutation that impairs the ability of lipoprotein receptors to localise in coated pits on the cell surface of human fibroblasts

1977 • 280 citations

Sequence requirements for the recognition of tyrosine-based endocytic signals by clathrin AP-2 complexes.

1996 • 272 citations

The targeting of Lamp1 to lysosomes is dependent on the spacing of its cytoplasmic tail tyrosine sorting motif relative to the membrane.

1996 • 258 citations

Possible pathways for lysosomal enzyme delivery.

1985 • 253 citations

The Medium Subunits of Adaptor Complexes Recognize Distinct but Overlapping Sets of Tyrosine-based Sorting Signals

1998 • 253 citations

μ1B, a novel adaptor medium chain expressed in polarized epithelial cells¹

1999 • 249 citations

A novel adaptor-related protein complex.

1996 • 241 citations

A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4

1998 • 232 citations

In Polarized MDCK Cells Basolateral Vesicles Arise from Clathrin-γ-adaptin–coated Domains on Endosomal Tubules

1998 • 220 citations

The Mammalian AP-3 Adaptor-like Complex Mediates the Intracellular Transport of Lysosomal Membrane Glycoproteins

1998 • 213 citations

Inhibition of the receptor-binding function of clathrin adaptor protein AP-2 by dominant-negative mutant μ2 subunit and its effects on endocytosis

1999 • 212 citations

A His-Leu-Leu sequence near the carboxyl terminus of the cytoplasmic domain of the cation-dependent mannose 6-phosphate receptor is necessary for the lysosomal enzyme sorting function.

1992 • 205 citations

Localization of the signal for rapid internalization of the bovine cation-independent mannose 6-phosphate/insulin-like growth factor-II receptor to amino acids 24-29 of the cytoplasmic tail.

1991 • 188 citations

Cytoplasmic determinants involved in direct lysosomal sorting, endocytosis, and basolateral targeting of rat lgp120 (lamp-I) in MDCK cells.

1995 • 130 citations

Distinct Saturable Pathways for the Endocytosis of Different Tyrosine Motifs

1998 • 118 citations

Functional Domain Mapping of the Clathrin-associated Adaptor Medium Chains ॖ1 and ॖ2

1997 • 93 citations

The LDL Receptor Clustering Motif Interacts with the Clathrin Terminal Domain in a Reverse Turn Conformation

1998 • 92 citations

Two rat homologs of clathrin-associated adaptor proteins

1994 • 77 citations

Efficient endosomal localization of major histocompatibility complex class II-invariant chain complexes requires multimerization of the invariant chain targeting sequence.

1995 • 64 citations

Specificity of interaction between adaptor-complex medium chains and the tyrosine-based sorting motifs of TGN38 and lgp120

1998 • 57 citations

The medium chains of the mammalian clathrin‐associated proteins have a homolog in yeast

1991 • 56 citations

Interactions of the AP-1 Golgi Adaptor with the Polymeric Immunoglobulin Receptor and Their Possible Role in Mediating Brefeldin A-sensitive Basolateral Targeting from the trans-Golgi Network

1999 • 46 citations

Identification of two new μ‐adaptin‐related proteins, μ‐ARP1 and μ‐ARP2

1997 • 25 citations