Accumulation of Sialic Acid in Endocytic Compartments Interferes with the Formation of Mature Lysosomes

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[41] Cathepsin B, cathepsin H, and cathepsin L

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1988 • 846 citations

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1991 • 595 citations

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1989 • 588 citations

Multivesicular endosomes containing internalized EGF-EGF receptor complexes mature and then fuse directly with lysosomes.

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1982 • 379 citations

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Two species of lysosomal organelles in cultured human fibroblasts

1979 • 360 citations

Transport from late endosomes to lysosomes, but not sorting of integral membrane proteins in endosomes, depends on the vacuolar proton pump.

1995 • 331 citations

Late endosomes derive from early endosomes by maturation

1991 • 311 citations

Role of the Occluding Loop in Cathepsin B Activity

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1983 • 235 citations

Dense core lysosomes can fuse with late endosomes and are re-formed from the resultant hybrid organelles

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1989 • 226 citations

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1992 • 181 citations

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1989 • 178 citations

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1994 • 173 citations

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1991 • 172 citations

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1996 • 170 citations

Distribution of newly synthesized lysosomal enzymes in the endocytic pathway of normal rat kidney cells.

1991 • 164 citations

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1985 • 159 citations

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1991 • 156 citations

Defective Sialic Acid Egress from Isolated Fibroblast Lysosomes of Patients with Salla Disease

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1979 • 139 citations

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1987 • 126 citations

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1989 • 114 citations

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1989 • 104 citations

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1987 • 104 citations

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1983 • 95 citations

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1992 • 94 citations

Characterization of recombinant rat cathepsin B and nonglycosylated mutants expressed in yeast. New insights into the pH dependence of cathepsin B-catalyzed hydrolyses.

1992 • 89 citations

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1982 • 85 citations

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Activation of procathepsin B in human hepatoma cells: the conversion into the mature enzyme relies on the action of cathepsin B itself

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Lysosomes can fuse with a late endosomal compartment in a cell-free system from rat liver.

1994 • 73 citations

Defective lysosomal egress of free sialic acid (N-acetylneuraminic acid) in fibroblasts of patients with infantile free sialic acid storage disease

1989 • 69 citations

The Kinetics of Mannose 6-Phosphate Receptor Trafficking in the Endocytic Pathway in HEp-2 Cells: The Receptor Enters and Rapidly Leaves Multivesicular Endosomes without Accumulating in a Prelysosomal Compartment

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On the effects of weak bases and monensin on sorting and processing of lysosomal enzymes in human cells.

1987 • 65 citations

Proteolytic processing of the alpha-chain of the lysosomal enzyme, beta-hexosaminidase, in normal human fibroblasts.

1988 • 63 citations

Accumulation of indigestible substances reduces fusion competence of macrophage lysosomes.

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Chromophoric and fluorophoric peptide substrates cleaved through the dipeptidyl carboxypeptidase activity of cathepsin B

1987 • 38 citations

Studies on the defect underlying the lysosomal storage of sialic acid in Salla disease. Lysosomal accumulation of sialic acid formed from N-acetyl-mannosamine or derived from low density lipoprotein in cultured mutant fibroblasts.

1986 • 32 citations

"Synchronized" endocytosis and intracellular sorting in alveolar macrophages: the early sorting endosome is a transient organelle.

1995 • 25 citations

Demonstration by electrospray mass spectrometry that the peptidyldipeptidase activity of cathepsin B is capable of rat cathepsin B C-terminal processing

1993 • 23 citations

Effects of pH, detergent and salt on aggregation of Chinese-hamster-ovary-cell lysosomal enzymes

1988 • 16 citations

Role of Na,K-ATPase in regulating acidification of early rat liver endocytic vesicles

1994 • 16 citations

Low Temperature Blocks Transport and Sorting of Cathepsin D in Fibroblasts

1988 • 15 citations

Impaired proteolytic processing of lysosomal N-acetyl-β-Hexosaminidase in cultured fibroblasts from patients with infantile generalized N-acetylneuraminic acid storage disease

1988 • 11 citations

Synthesis and processing of lysosomal α-fucosidase in cultured human fibroblasts

1991 • 4 citations