Genetic Dissection of Endocytic Trafficking inDrosophilaUsing a Horseradish Peroxidase-Bride of Sevenless Chimera:hookIs Required for Normal Maturation of Multivesicular Endosomes

The Genome of Drosophila Melanogaster

1992 • 3,126 citations

Genetic Transformation of Drosophila with Transposable Element Vectors

1982 • 2,995 citations

DEVELOPMENT IN DROSOPHILA MELANOGASTER

1927 • 2,909 citations

Endocytosis

1997 • 1,263 citations

Induction of mutant dynamin specifically blocks endocytic coated vesicle formation.

1994 • 1,206 citations

Dynamin-like protein encoded by the Drosophila shibire gene associated with vesicular traffic

1991 • 757 citations

Dynamin Undergoes a GTP-Dependent Conformational Change Causing Vesiculation

1998 • 665 citations

Membrane transport in the endocytic pathway

1995 • 644 citations

Multiple forms of dynamin are encoded by shibire, a Drosophila gene involved in endocytosis

1991 • 543 citations

Multivesicular endosomes containing internalized EGF-EGF receptor complexes mature and then fuse directly with lysosomes.

1996 • 531 citations

Sorting of membrane components from endosomes and subsequent recycling to the cell surface occurs by a bulk flow process.

1993 • 516 citations

Kinase activity controls the sorting of the epidermal growth factor receptor within the multivesicular body

1990 • 452 citations

Clathrin-independent pinocytosis is induced in cells overexpressing a temperature-sensitive mutant of dynamin.

1995 • 400 citations

lag-2 may encode a signaling ligand for the GLP-1 and LIN-12 receptors of C. elegans

1994 • 385 citations

Generation of Coated Intermediates of Clathrin-Mediated Endocytosis on Protein-Free Liposomes

1998 • 345 citations

Reversible blockage of membrane retrieval and endocytosis in the garland cell of the temperature-sensitive mutant of Drosophila melanogaster, shibirets1.

1983 • 332 citations

Serotonin-Mediated Endocytosis of apCAM: an Early Step of Learning-Related Synaptic Growth in Aplysia

1992 • 313 citations

Late endosomes derive from early endosomes by maturation

1991 • 311 citations

Possible temperature‐dependent blockage of synaptic vesicle recycling induced by a single gene mutation in drosophila

1983 • 303 citations

Interaction of bride of sevenless membrane-bound ligand and the sevenless tyrosine-kinase receptor

1991 • 298 citations

Localization of the sevenless protein, a putative receptor for positional information, in the eye imaginal disc of Drosophila

1987 • 279 citations

Mutant Rab7 Causes the Accumulation of Cathepsin D and Cation-independent Mannose 6–Phosphate Receptor in an Early Endocytic Compartment

1998 • 265 citations

Requirement for Dynamin during Notch Signaling inDrosophilaNeurogenesis

1997 • 265 citations

The AP-3 complex: a coat of many colours

1998 • 237 citations

Fusion of Lysosomes with Late Endosomes Produces a Hybrid Organelle of Intermediate Density and Is NSF Dependent

1998 • 216 citations

Quantification of low density lipoprotein and transferrin endocytic sorting in HEp2 cells using confocal microscopy

1994 • 212 citations

Serrate and wingless cooperate to induce vestigial gene expression and wing formation in Drosophila

1995 • 206 citations

Abnormal transport along the lysosomal pathway in Mucolipidosis, type IV disease

1998 • 202 citations

Vam7p, a SNAP-25-Like Molecule, and Vam3p, a Syntaxin Homolog, Function Together in Yeast Vacuolar Protein Trafficking

1998 • 199 citations

VPS21 encodes a rab5-like GTP binding protein that is required for the sorting of yeast vacuolar proteins.

1994 • 190 citations

Delivery of ligands from sorting endosomes to late endosomes occurs by maturation of sorting endosomes

1992 • 187 citations

Receptor-Mediated Protein Sorting to the Vacuole in Yeast: Roles for a Protein Kinase, a Lipid Kinase and GTP-Binding Proteins

1995 • 184 citations

The bride of sevenless and sevenless interaction: Internalization of a transmembrane ligand

1992 • 172 citations

Protein traffic in the yeast endocytic and vacuolar protein sorting pathways

1998 • 164 citations

Induction of cell fate in the Drosophila retina: the bride of sevenless protein is predicted to contain a large extracellular domain and seven transmembrane segments.

1990 • 164 citations

Not just pretty eyes: Drosophila eye-colour mutations and lysosomal delivery

1998 • 159 citations

Induction in the developing compound eye of Drosophila: Multiple mechanisms restrict R7 induction to a single retinal precursor cell

1991 • 155 citations

Multivesicular bodies in HEp-2 cells are maturing endosomes.

1993 • 154 citations

Mutations in the Drosophila hook gene inhibit endocytosis of the boss transmembrane ligand into multivesicular bodies.

1996 • 153 citations

Transport into and out of the Golgi complex studied by transfecting cells with cDNAs encoding horseradish peroxidase.

1994 • 147 citations

Delivery to lysosomes in the human carcinoma cell line HEp-2 involves an actin filament-facilitated fusion between mature endosomes and preexisting lysosomes.

1995 • 122 citations

Complex Proteolytic Processing Acts on Delta, a Transmembrane Ligand for Notch, duringDrosophilaDevelopment

1998 • 103 citations

Anterograde and retrograde traffic between the rough endoplasmic reticulum and the Golgi complex.

1995 • 102 citations

Genetic Analysis of hook, a Gene Required for Endocytic Trafficking in Drosophila

1999 • 99 citations

Yeast endocytosis

1993 • 66 citations

The Kinetics of Mannose 6-Phosphate Receptor Trafficking in the Endocytic Pathway in HEp-2 Cells: The Receptor Enters and Rapidly Leaves Multivesicular Endosomes without Accumulating in a Prelysosomal Compartment

1998 • 66 citations

Genetic Studies on Dynamin Function inDrosophila

1993 • 57 citations

Synchronized endocytosis studied in the oocyte of a temperature-sensitive mutant of Drosophila melanogaster

1990 • 49 citations

Baculovirus expression and characterization of catalytically active horseradish peroxidase

1992 • 44 citations

Extracellular domain of the boss transmembrane ligand acts as an antagonist of the sev receptor

1993 • 40 citations

The interaction of bride of sevenless with sevenless is conserved between Drosophila virilis and Drosophila melanogaster.

1993 • 16 citations

Oligomerization of the extracellular domain of Boss enhances its binding to the Sevenless receptor and its antagonistic effect on R7 induction

1998 • 7 citations