Phosphorylation State-Specific Antibodies

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology.

1986 • 3,430 citations

Monoclonal antibodies distinguish phosphorylated and nonphosphorylated forms of neurofilaments in situ.

1983 • 1,162 citations

The origins of protein phosphorylation

2002 • 1,047 citations

Monoclonal antibodies to mitotic cells.

1983 • 609 citations

Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as Alzheimer's disease paired helical filament tau

1994 • 561 citations

Activation of mitogen-activated protein kinase associated with prostate cancer progression.

1999 • 539 citations

THE ENZYMATIC PHOSPHORYLATION OF PROTEINS

1954 • 537 citations

Constitutive activation of Stat3 in human prostate tumors and cell lines: direct inhibition of Stat3 signaling induces apoptosis of prostate cancer cells.

2002 • 526 citations

Pharmacodynamic Studies of the Epidermal Growth Factor Receptor Inhibitor ZD1839 in Skin From Cancer Patients: Histopathologic and Molecular Consequences of Receptor Inhibition

2002 • 490 citations

Signal transducer and activator of transcription 6 is frequently activated in Hodgkin and Reed-Sternberg cells of Hodgkin lymphoma

2002 • 291 citations

Activated extracellular signal-regulated kinases: association with epidermal growth factor receptor/transforming growth factor alpha expression in head and neck squamous carcinoma and inhibition by anti-epidermal growth factor receptor treatments.

2001 • 281 citations

A Spatial Gradient of Tau Protein Phosphorylation in Nascent Axons

1996 • 258 citations

Frequent Loss of PTEN Expression Is Linked to Elevated Phosphorylated Akt Levels, but Not Associated with p27 and Cyclin D1 Expression, in Primary Epithelial Ovarian Carcinomas

2001 • 251 citations

Phosphorylation of ERK1/2 mitogen-activated protein kinase is associated with poor response to anti-hormonal therapy and decreased patient survival in clinical breast cancer

2001 • 250 citations

Pharmacodynamic Studies of the Epidermal Growth Factor Receptor Inhibitor ZD1839 in Skin From Cancer Patients: Histopathologic and Molecular Consequences of Receptor Inhibition

2002 • 244 citations

Monoclonal antibodies to phosphotyrosine

1988 • 242 citations

Alterations of Smad signaling in human breast carcinoma are associated with poor outcome: a tissue microarray study.

2002 • 219 citations

Active MAP Kinase in Mitosis: Localization at Kinetochores and Association with the Motor Protein CENP-E

1998 • 215 citations

Activation of signal transducer and activator of transcription (STAT) 1 in human chronic inflammatory bowel disease

2002 • 205 citations

Tackling the phosphoproteome: tools and strategies

2003 • 204 citations

Phosphotyrosine-containing proteins isolated by affinity chromatography with antibodies to a synthetic hapten

1981 • 203 citations

The AKT kinase is activated in multiple myeloma tumor cells

2001 • 193 citations

Activation (Tyrosine Phosphorylation) of ErbB-2 (HER-2/neu): A Study of Incidence and Correlation With Outcome in Breast Cancer

2000 • 175 citations

Effects of the epidermal growth factor receptor inhibitor OSI-774, Tarceva, on downstream signaling pathways and apoptosis in human pancreatic adenocarcinoma.

2002 • 161 citations

Increased Expression of the Interleukin-11 Receptor and Evidence of STAT3 Activation in Prostate Carcinoma

2001 • 151 citations

Cytoplasmic Aggregates of Phosphorylated Extracellular Signal-Regulated Protein Kinases in Lewy Body Diseases

2002 • 146 citations

Loss of PTEN expression followed by Akt phosphorylation is a poor prognostic factor for patients with endometrial cancer.

2003 • 144 citations

NF-κB is constitutively activated in high-grade squamous intraepithelial lesions and squamous cell carcinomas of the human uterine cervix

2003 • 141 citations

[23] Production of phosphorylation state-specific antibodies

1991 • 132 citations

Tyrosine phosphorylation of paxillin FAK AND p130CAS effects on cell spreading and migration

2002 • 130 citations

Amplification of Tissue by Construction of Tissue Microarrays

2001 • 130 citations

Expression of constitutively activated EGFRvlll in non‐small cell lung cancer

2003 • 129 citations

SCF ubiquitin protein ligases and phosphorylation–dependent proteolysis

1999 • 128 citations

In Situ Visualization of Intratumor Growth Factor Signaling

1998 • 125 citations

Tissue microarray analysis of beta-catenin in colorectal cancer shows nuclear phospho-beta-catenin is associated with a better prognosis.

2001 • 116 citations

Insulin-like growth factor I receptor activity in human medulloblastomas.

2002 • 101 citations

Analysis of Signal Transducer and Activator of Transcription 3 (Stat 3) Pathway in Multiple Myeloma

2003 • 94 citations

Non‐small cell lung cancers frequently express phosphorylated Akt; an immunohistochemical study

2002 • 94 citations

Biological and clinical associations of c-jun activation in human breast cancer

2000 • 93 citations

ERK/MAP kinase is chronically activated in human reactive astrocytes

1999 • 92 citations

Hepatocyte Cytokeratins Are Hyperphosphorylated at Multiple Sites in Human Alcoholic Hepatitis and in a Mallory Body Mouse Model

2000 • 90 citations

Dysregulated PTEN‐PKB and negative receptor status in human breast cancer

2003 • 88 citations

Type 1 receptor tyrosine kinases are differentially phosphorylated in mammary carcinoma and differentially associated with steroid receptors.

1996 • 86 citations

Activation state-specific monoclonal antibody detects tyrosine phosphorylated p185neu/erbB-2 in a subset of human breast tumors overexpressing this receptor.

1995 • 85 citations

Phosphorylation, But Not Overexpression, of Epidermal Growth Factor Receptor Is Associated With Poor Prognosis of Non-Small Cell Lung Cancer Patients

2003 • 81 citations

Activation of the IGF-IR system contributes to malignant growth of human and mouse medulloblastomas

2001 • 79 citations

Increased Expression of Phosphorylated p70S6 Kinase and Akt in Papillary Thyroid Cancer Tissues

2003 • 78 citations

Increased Phosphorylated Extracellular Signal-Regulated Kinase Immunoreactivity Associated with Proliferative and Morphologic Lung Alterations after Chrysotile Asbestos Inhalation in Mice

2000 • 75 citations

Basal Activation of Transcription Factor Signal Transducer and Activator of Transcription (Stat5) in Nonpregnant Mouse and Human Breast Epithelium

2002 • 75 citations

Inactivation of retinoblastoma protein in uveal melanoma by phosphorylation of sites in the COOH-terminal region.

2000 • 69 citations

Activation of Phospholipase Cγ2 by Tyrosine Phosphorylation

2002 • 64 citations

A monoclonal antibody to the phosphorylated form of glial fibrillary acidic protein: Application to a non-radioactive method for measuring protein kinase activities

1991 • 61 citations

Synthetic phosphopeptide immunogens yield activation-specific antibodies to the c-erbB-2 receptor.

1992 • 57 citations

Tau gene mutations and neurodegeneration

2001 • 56 citations

Mechanism of Mitosis-specific Activation of MEK1

2003 • 53 citations

Epidermal growth factor receptor expression and activation in nonseminomatous germ cell tumors.

2001 • 52 citations

Retroviruses and Oncogenes I

1990 • 50 citations

Antiserum raised against a synthetic phosphotyrosine-containing peptide selectively recognizes p185neu/erbB-2 and the epidermal growth factor receptor.

1992 • 46 citations

Agarose Mold Embedding of Cultured Cells for Tissue Microarrays

2002 • 45 citations

Recognition of activated CSF-1 receptor in breast carcinomas by a tyrosine 723 phosphospecific antibody

1997 • 43 citations

Frequent phosphorylation at serine 392 in overexpressed p53 protein due to missense mutation in carcinoma of the urinary tract

2002 • 27 citations

Antibodies directed against phosphothreonine residues as potent tools for studying protein phosphorylation

1989 • 23 citations

AP-1 and heat shock protein 27 expression in human astrocytomas

2001 • 22 citations

Characterization of an Antibody That Can Detect an Activated IGF-I Receptor in Human Cancers

1999 • 19 citations

Association of ErbB2 Ser1113 phosphorylation with epidermal growth factor receptor co-expression and poor prognosis in human breast cancer.

2001 • 18 citations

Immunohistochemical screening for oncogenic tyrosine kinase activation

1999 • 16 citations

Alterations of cell cycle regulators affecting the RB pathway in nonfamilial retinoblastoma

2001 • 16 citations

Low Initial Tau Phosphorylation in Human Brain Biopsy Samples

1997 • 14 citations

The muscle mitogen-activated protein kinase is altered in sporadic inclusion body myositis

2000 • 14 citations

Adjacent Carboxyterminal Tyrosine Phosphorylation Events Identify Functionally Distinct ErbB2 Receptor Subsets: Implications for Molecular Diagnostics

1998 • 13 citations

Multisite phosphotyping of the ErbB-2 oncoprotein in human breast cancer.

2001 • 11 citations

Increase of phosphotyrosine-containing proteins in human carcinomas.

1985 • 10 citations

Histone H3 is aberrantly phosphorylated in glutamine-repeat diseases

2003 • 9 citations

Activation of Phospholipase C 2 by Tyrosine Phosphorylation

2002 • 8 citations

Multisite Phosphotyping of the ErbB-2 Oncoprotein in Human Breast Cancer

2001 • 6 citations

Immunohistochemical visualization of histone H1 phosphorylation in squamous intraepithelial lesions of the gynecologic tract

2003 • 6 citations

International Congress on Hormonal Steroids and Hormones and Cancer Loss of PTEN expression followed by Akt phosphorylation is a poor prognostic factor for patients with endometrial cancer

2003 • 1 citations