International Congress on Hormonal Steroids and Hormones and Cancer Loss of PTEN expression followed by Akt phosphorylation is a poor prognostic factor for patients with endometrial cancer

The Tumor Suppressor, PTEN/MMAC1, Dephosphorylates the Lipid Second Messenger, Phosphatidylinositol 3,4,5-Trisphosphate

1998 • 3,053 citations

Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN

1998 • 2,505 citations

Inhibition of Cell Migration, Spreading, and Focal Adhesions by Tumor Suppressor PTEN

1998 • 1,215 citations

The Multiple Roles of PTEN in Tumor Suppression

2000 • 1,150 citations

Crystal Structure of the PTEN Tumor Suppressor

1999 • 1,011 citations

Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignancies.

1997 • 689 citations

PTEN/MMAC1 mutations in endometrial cancers.

1997 • 517 citations

Molecular pathology of endometrial hyperplasia and carcinoma

2001 • 301 citations

Genetic deletion of the Pten tumor suppressor gene promotes cell motility by activation of Rac1 and Cdc42 GTPases

2000 • 291 citations

PTEN methylation is associated with advanced stage and microsatellite instability in endometrial carcinoma

2000 • 290 citations

PTEN mutations and microsatellite instability in complex atypical hyperplasia, a precursor lesion to uterine endometrioid carcinoma.

1998 • 286 citations

PTEN mutation in endometrial cancers is associated with favorable clinical and pathologic characteristics.

1998 • 270 citations

Mutation of the PTEN tumor suppressor gene in endometrial hyperplasias.

1998 • 228 citations

PTEN gene transfer in human malignant glioma: sensitization to irradiation and CD95L-induced apoptosis

1999 • 112 citations

MMAC1/PTEN inhibits cell growth and induces chemosensitivity to doxorubicin in human bladder cancer cells

2000 • 102 citations