Increased Expression of the Interleukin-11 Receptor and Evidence of STAT3 Activation in Prostate Carcinoma

STATs and Gene Regulation

1997 • 3,927 citations

Cancer statistics, 1999

1999 • 3,154 citations

Stat3 as an Oncogene

1999 • 2,770 citations

Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway

1998 • 2,072 citations

Constitutive Activation of Stat3 Signaling Confers Resistance to Apoptosis in Human U266 Myeloma Cells

1999 • 1,655 citations

Interleukin-6 family of cytokines and gp130

1995 • 1,314 citations

Choice of STATs and Other Substrates Specified by Modular Tyrosine-Based Motifs in Cytokine Receptors

1995 • 992 citations

Association and Activation of Jak-Tyk Kinases by CNTF-LIF-OSM-IL-6 β Receptor Components

1994 • 972 citations

Enhanced DNA-Binding Activity of a Stat3-Related Protein in Cells Transformed by the Src Oncoprotein

1995 • 945 citations

Molecular cloning of a cDNA encoding interleukin 11, a stromal cell-derived lymphopoietic and hematopoietic cytokine.

1990 • 649 citations

Stat3 Activation Is Required for Cellular Transformation by v-src

1998 • 624 citations

Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor- mediated cell growth In vitro.

1998 • 508 citations

Interleukin-11: a new cytokine critical for osteoclast development.

1994 • 408 citations

Interleukin-11: Review of Molecular, Cell Biology, and Clinical Use

1997 • 386 citations

Constitutive activation of Stat3 in fibroblasts transformed by diverse oncoproteins and in breast carcinoma cells.

1997 • 370 citations

Constitutive activation of STAT proteins in primary lymphoid and myeloid leukemia cells and in Epstein-Barr virus (EBV)-related lymphoma cell lines

1996 • 318 citations

Gene therapy with dominant-negative Stat3 suppresses growth of the murine melanoma B16 tumor in vivo.

1999 • 315 citations

STAT-related transcription factors are constitutively activated in peripheral blood cells from acute leukemia patients

1996 • 312 citations

Transcription factor p91 interacts with the epidermal growth factor receptor and mediates activation of the c-fos gene promoter

1993 • 306 citations

Interleukin-6: A candidate mediator of human prostate cancer morbidity

1995 • 293 citations

Constitutive activation of JAKs and STATs in BCR-Abl-expressing cell lines and peripheral blood cells derived from leukemic patients.

1997 • 283 citations

Interleukin-6 induces prostate cancer cell growth accompanied by activation of Stat3 signaling pathway

2000 • 273 citations

Interleukin 6 activates androgen receptor-mediated gene expression through a signal transducer and activator of transcription 3-dependent pathway in LNCaP prostate cancer cells.

2000 • 256 citations

Inhibition of constitutively activated Stat3 signaling pathway suppresses growth of prostate cancer cells.

2000 • 212 citations

Interleukin-11 prevents apoptosis and accelerates recovery of small intestinal mucosa in mice treated with combined chemotherapy and radiation.

1996 • 186 citations

IL-11, a pleiotropic cytokine: exciting new effects of IL-11 on gastrointestinal mucosal biology.

1994 • 127 citations

Expression of transcripts of interleukin-6 and related cytokines by human breast tumors, breast cancer cells, and adipose stromal cells

1996 • 120 citations

Interleukin‐11 protects the clonogenic stem cells in murine small‐intestinal crypts from impairment of their reproductive capacity by radiation

1995 • 108 citations

Mitogen-activated protein kinases and ribosomal S6 protein kinases are involved in signaling pathways shared by interleukin-11, interleukin-6, leukemia inhibitory factor, and oncostatin M in mouse 3T3-L1 cells.

1994 • 105 citations

Interleukin-11 inhibits adipogenesis and stimulates myelopoiesis in human long-term marrow cultures

1993 • 100 citations

Expression and function of members of the cytokine receptor superfamily on breast cancer cells

1997 • 94 citations

Activation of the signal transducer gp130 by interleukin-11 and interleukin-6 is mediated by similar molecular interactions

1998 • 80 citations

Protective effects of interleukin-11 in a murine model of ischemic bowel necrosis

1997 • 80 citations

Expression and function of colony-stimulating factors and their receptors in human prostate carcinoma cell lines

1998 • 64 citations

Complex Formation of JAK2 with PP2A, PI3K, and Yes in Response to the Hematopoietic Cytokine Interleukin-11

1996 • 62 citations

Expression of multiple angiogenic cytokines in cultured normal human prostate epithelial cells: Predominance of vascular endothelial growth factor

1999 • 55 citations

Identification of a 130-kilodalton tyrosine-phosphorylated protein induced by interleukin-11 as JAK2 tyrosine kinase, which associates with gp130 signal transducer.

1994 • 52 citations

Production and regulation of interleukin-11 by breast cancer cells

1998 • 52 citations

Tyrosine Phosphorylation of Jak-Tyk Kinases in Malignant Plasma Cell Lines Growth Stimulated by Interleukins 6 and 11

1994 • 51 citations

Interleukin (IL)‐11‐mediated Signal Transductiona

1995 • 45 citations

Activation of Src-family protein tyrosine kinases and phosphatidylinositol 3-kinase in 3T3-L1 mouse preadipocytes by interleukin-11.

1996 • 32 citations