Mechanism of Mitosis-specific Activation of MEK1

Principles of CDK regulation

1995 • 3,267 citations

Biochemical and Cellular Effects of Roscovitine, a Potent and Selective Inhibitor of the Cyclin‐Dependent Kinases cdc2, cdk2 and cdk5

1997 • 1,324 citations

Cyclin D1 Expression Is Regulated Positively by the p42/p44 and Negatively by the p38/HOG Pathway

1996 • 1,203 citations

Proteolytic Inactivation of MAP-Kinase-Kinase by Anthrax Lethal Factor

1998 • 1,003 citations

K-ras is an essential gene in the mouse with partial functional overlap with N-ras

1997 • 537 citations

Regulatory phosphorylation of the p34cdc2 protein kinase in vertebrates.

1991 • 502 citations

Ras Isoforms Vary in Their Ability to Activate Raf-1 and Phosphoinositide 3-Kinase

1998 • 475 citations

MP1: A MEK Binding Partner That Enhances Enzymatic Activation of the MAP Kinase Cascade

1998 • 471 citations

A MAP kinase-dependent spindle assembly checkpoint in Xenopus egg extracts

1994 • 402 citations

Cytoplasmic accumulation of cdc25B phosphatase in mitosis triggers centrosomal microtubule nucleation in HeLa cells

1996 • 234 citations

Activation of the MKK/ERK Pathway during Somatic Cell Mitosis: Direct Interactions of Active ERK with Kinetochores and Regulation of the Mitotic 3F3/2 Phosphoantigen

1998 • 223 citations

Active MAP Kinase in Mitosis: Localization at Kinetochores and Association with the Motor Protein CENP-E

1998 • 215 citations

A Proline-Rich Sequence Unique to MEK1 and MEK2 Is Required for Raf Binding and Regulates MEK Function

1995 • 196 citations

Taxol induction of p21WAF1 and p53 requires c-raf-1.

1995 • 187 citations

A Conserved Docking Site in MEKs Mediates High-affinity Binding to MAP Kinases and Cooperates with a Scaffold Protein to Enhance Signal Transmission

2001 • 179 citations

Mitogen-activated protein kinase kinase activity is required for the G ₂ /M transition of the cell cycle in mammalian fibroblasts

1999 • 175 citations

Biphasic activation of two mitogen-activated protein kinases during the cell cycle in mammalian cells.

1992 • 153 citations

Distinct Cell Cycle Timing Requirements for Extracellular Signal-Regulated Kinase and Phosphoinositide 3-Kinase Signaling Pathways in Somatic Cell Mitosis

2002 • 145 citations

Vitamin D3-induced Apoptosis of Murine Squamous Cell Carcinoma Cells

2001 • 141 citations

Characterization of RasGRP2, a Plasma Membrane-targeted, Dual Specificity Ras/Rap Exchange Factor

2000 • 130 citations

Activity of Plasma Membrane-recruited Raf-1 Is Regulated by Ras via the Raf Zinc Finger

1997 • 117 citations

Cell Cycle Regulation of p70 S6 Kinase and p42/p44 Mitogen-activated Protein Kinases in Swiss Mouse 3T3 Fibroblasts

1996 • 103 citations

A Specific Activation of the Mitogen-Activated Protein Kinase Kinase 1 (Mek1) Is Required for Golgi Fragmentation during Mitosis

2000 • 99 citations

Cdc25 inhibition and cell cycle arrest by a synthetic thioalkyl vitamin K analogue.

2000 • 99 citations

Mitogen-activated protein kinase kinase 1 (MKK1) is negatively regulated by threonine phosphorylation.

1994 • 97 citations

Raf-1/MEK/MAPK Pathway Is Necessary for the G2/M Transition Induced by Nocodazole

2000 • 97 citations

Activation of the p42 Mitogen-activated Protein Kinase Pathway Inhibits Cdc2 Activation and Entry into M-Phase in CyclingXenopusEgg Extracts

1998 • 61 citations

Accumulation of p16CDKN2A in response to ultraviolet irradiation correlates with late S-G(2)-phase cell cycle delay.

1996 • 59 citations

Endogenous c-N-Ras Provides a Steady-state Anti-apoptotic Signal

2000 • 57 citations

Activation of Wee1 by p42 MAPK In Vitro and in CyclingXenopusEgg Extracts

2000 • 53 citations

Characterization of Raf-1 Activation in Mitosis

1999 • 45 citations