Retroviruses and Oncogenes I

Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ neu Oncogene

1987 • 11,429 citations

Studies of the HER-2/ neu Proto-Oncogene in Human Breast and Ovarian Cancer

1989 • 6,734 citations

Genetic regulatory mechanisms in the synthesis of proteins

1961 • 6,378 citations

Transforming gene product of Rous sarcoma virus phosphorylates tyrosine

1980 • 2,387 citations

Amplification of N- myc in Untreated Human Neuroblastomas Correlates with Advanced Disease Stage

1984 • 2,248 citations

PROTEIN-TYROSINE KINASES

1985 • 2,198 citations

Viral RNA-dependent DNA Polymerase: RNA-dependent DNA Polymerase in Virions of Rous Sarcoma Virus

1970 • 2,061 citations

The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain

1986 • 2,020 citations

Viral RNA-dependent DNA Polymerase: RNA-dependent DNA Polymerase in Virions of RNA Tumour Viruses

1970 • 1,992 citations

Association of Multiple Copies of the N-mycOncogene with Rapid Progression of Neuroblastomas

1985 • 1,989 citations

Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome

1982 • 1,790 citations

The Molecular Genetics of Cancer

1987 • 1,729 citations

Activation of a cellular onc gene by promoter insertion in ALV-induced lymphoid leukosis

1981 • 1,611 citations

Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour

1983 • 1,407 citations

DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA

1976 • 1,290 citations

Protein kinase activity associated with the avian sarcoma virus src gene product.

1978 • 1,137 citations

A SARCOMA OF THE FOWL TRANSMISSIBLE BY AN AGENT SEPARABLE FROM THE TUMOR CELLS

1911 • 995 citations

Characterization of ribosomal frameshifting in HIV-1 gag-pol expression

1988 • 936 citations

Identification of a transformation-specific antigen induced by an avian sarcoma virus

1977 • 931 citations

Spontaneous mammary adenocarcinomas in transgenic mice that carry and express MTV/myc fusion genes

1984 • 906 citations

ONCOGENES OF RNA TUMOR VIRUSES AS DETERMINANTS OF CANCER

1969 • 868 citations

RNA tumor viruses

1982 • 833 citations

Suppression of the Neoplastic Phenotype by Replacement of the RB Gene in Human Cancer Cells

1988 • 832 citations

THE MOLECULAR GENETICS OF CELLULAR ONCOGENES

1984 • 765 citations

Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice

1988 • 745 citations

THE myc ONCOGENE: ITS ROLE IN TRANSFORMATION AND DIFFERENTIATION

1986 • 714 citations

Transposition and amplification of oncogene-related sequences in human neuroblastomas

1983 • 711 citations

Evidence that the transforming gene of avian sarcoma virus encodes a protein kinase associated with a phosphoprotein

1978 • 673 citations

Form and Function of Retroviral Proviruses

1982 • 627 citations

Multiple arrangements of viral DNA and an activated host oncogene in bursal lymphomas

1982 • 624 citations

Signals for ribosomal frameshifting in the rous sarcoma virus gag-pol region

1988 • 617 citations

Mode of proviral activation of a putative mammary oncogene (int-1) on mouse chromosome 15

1984 • 609 citations

SOME POSSIBLE EFFECTS OF NURSING ON THE MAMMARY GLAND TUMOR INCIDENCE IN MICE

1936 • 596 citations

Structure and sequence of the cellular gene homologous to the RSV src gene and the mechanism for generating the transforming virus

1983 • 586 citations

Avian leukosis virus-induced tumors have common proviral integration sites and synthesize discrete new RNAs: oncogenesis by promoter insertion

1981 • 533 citations

Specific chromosomal translocations and the genesis of B-cell-derived tumors in mice and men

1983 • 517 citations

Retroviruses

1988 • 512 citations

Expression of the Rous Sarcoma Virus pol Gene by Ribosomal Frameshifting

1985 • 471 citations

Recent progress in understanding mechanisms of mammalian DNA amplification

1989 • 469 citations

The Approaching Era of the Tumor Suppressor Genes

1987 • 468 citations

Correct integration of retroviral DNA in vitro

1987 • 459 citations

Avian sarcoma virus 17 carries the jun oncogene.

1987 • 445 citations

Rous Sarcoma Virus: a Function required for the Maintenance of the Transformed State

1970 • 444 citations

Three new types of viral oncogene of cellular origin specific for haematopoietic cell transformation

1979 • 424 citations

The effects of reciprocal changes in temperature on the transformed state of cells infected with a Rous sarcoma virus mutant

1971 • 411 citations

Cell Transformation by the Viral src Oncogene

1987 • 405 citations

Enhanced expression of the human gene N-myc consequent to amplification of DNA may contribute to malignant progression of neuroblastoma.

1984 • 400 citations

Retroviral DNA integration: Structure of an integration intermediate

1988 • 397 citations

Dual evolutionary origin for the rat genetic sequences of Harvey murine sarcoma virus

1980 • 387 citations

Uninfected vertebrate cells contain a protein that is closely related to the product of the avian sarcoma virus transforming gene (src).

1979 • 378 citations

Neurones express high levels of a structurally modified, activated form of pp60c-src

1985 • 372 citations

Oncogene Amplification in Tumor Cells

1986 • 353 citations

Analysis of avian leukosis virus DNA and RNA in bursal tumors: Viral gene expression is not required for maintenance of the tumor state

1981 • 346 citations

Proviruses of avian sarcoma virus are terminally redundant, co-extensive with unintegrated linear DNA and integrated at many sites

1978 • 342 citations

Nucleotide sequence of an avian sarcoma virus oncogene (src) and proposed amino acid sequence for gene product

1980 • 324 citations

Enemies within: the genesis of retrovirus oncogenes

1981 • 303 citations

Virus-Specific Ribonucleic Acid in Cells Producing Rous Sarcoma Virus: Detection and Characterization

1972 • 302 citations

Isolation and characterization of c-myc, a cellular homolog of the oncogene (v-myc) of avian myelocytomatosis virus strain 29

1982 • 299 citations

Quantitation of simian virus 40 sequences in African green monkey, mouse and virus-transformed cell genomes

1971 • 292 citations

A tail of two src's: Mutatis mutandis

1987 • 278 citations

DNA and RNA from Uninfected Vertebrate Cells Contain Nucleotide Sequences Related to the Putative Transforming Gene of Avian Myelocytomatosis Virus

1979 • 273 citations

Human N-myc is closely related in organization and nucleotide sequence to c-myc

1986 • 273 citations

Retroviruses and Retrotransposons: The role of reverse transcription in shaping the eukaryotic genome

1985 • 273 citations

DNA sequences homologous to vertebrate oncogenes are conserved in Drosophila melanogaster.

1981 • 269 citations

The purified product of the transforming gene of avian sarcoma virus phosphorylates tyrosine.

1980 • 269 citations

Retroviruses as mutagens: Insertion and excision of a nontransforming provirus alter expression of a resident transforming provirus

1981 • 253 citations

Purification of DNA complementary to nucleotide sequences required for neoplastic transformation of fibroblasts by avian sarcoma viruses

1976 • 252 citations

Characterization of a normal avian cell protein related to the avian sarcoma virus transforming gene product

1978 • 251 citations

Nucleotide sequences related to the transforming gene of avian sarcoma virus are present in DNA of uninfected vertebrates.

1978 • 245 citations

Mapping RNase T1-resistant oligonucleotides of avian tumor virus RNAs: sarcoma-specific oligonucleotides are near the poly(A) end and oligonucleotides common to sarcoma and transformation-defective viruses are at the poly(A) end

1975 • 241 citations

Mitosis-specific phosphorylation of p60c-src by p34cdc2-associated protein kinase

1989 • 239 citations

The molecular biology of the mammalian genetic apparatus

1977 • 239 citations

A point mutation at codon 13 of the N-ras oncogene in myelodysplastic syndrome

1987 • 231 citations

Spontaneous segregation of nontransforming viruses from cloned sarcoma viruses

1971 • 212 citations

Analysis of unintegrated avian RNA tumor virus double-stranded DNA intermediates

1978 • 210 citations

The size and genetic composition of virus-specific RNAs in the cytoplasm of cells producing avian sarcoma-leukosis viruses

1977 • 207 citations

Biologic Synthesis of Deoxyribonucleic Acid

1960 • 204 citations

Integration of the DNA of mouse mammary tumor virus in virus-infected normal and neoplastic tissue of the mouse

1979 • 195 citations

Expression of v-src and chicken c-src in rat cells demonstrates qualitative differences between pp60v-src and pp60c-src

1984 • 194 citations

A retrovirus vector expressing the putative mammary oncogene int-1 causes partial transformation of a mammary epithelial cell line

1986 • 189 citations

A normal cell protein similar in structure and function to the avian sarcoma virus transforming gene product.

1979 • 187 citations

Nucleotide sequence to the v-myc oncogene of avian retrovirus MC29.

1983 • 184 citations

Transcription of DNA from the 70 S RNA of Rous Sarcoma Virus I. Identification of a Specific 4 S RNA Which Serves as Primer

1974 • 184 citations

Activated Proto-onc Genes: Sufficient or Necessary for Cancer?

1985 • 182 citations

Contrasting patterns of myc and N-myc expression during gastrulation of the mouse embryo.

1989 • 172 citations

Site on the RNA of an avian sarcoma virus at which primer is bound

1975 • 170 citations

ONCOGENE ACTIVATION BY CHROMOSOME TRANSLOCATION IN HUMAN MALIGNANCY

1987 • 169 citations

A joint product of the genes gag and pol of Avian Sarcoma Virus: a possible precursor of reverse transcriptase

1977 • 166 citations

Cyclic AMP regulates Catabolite and Transient Repression in E. coli

1969 • 165 citations

The Proteins of Oncogenes

1984 • 163 citations

RAS mutations in myelodysplasia detected by amplification, oligonucleotide hybridization, and transformation.

1988 • 162 citations

Detection of Avian Tumor Virus-Specific Nucleotide Sequences in Avian Cell DNAs

1972 • 152 citations

Mutations of the Kirsten-ras proto-oncogene in human preleukaemia

1987 • 146 citations

Virus Recovery in Chicken Cells Tested with Rous Sarcoma Cell DNA

1972 • 142 citations

Specific RNA sequences and gene products of MC29 avian acute leukemia virus

1978 • 134 citations

Hormonal regulation of the rous sarcoma virus src gene via a heterologous promoter defines a threshold dose for cellular transformation

1984 • 132 citations

Heterogeneity of genetic loci in chickens: analysis of endogenous viral and nonviral genes by cleavage of DNA with restriction endonucleases

1979 • 132 citations

Regulation of HIV and HTLV gene expression.

1988 • 128 citations

The requirement for DNA synthesis in the growth of rous sarcoma and rous-associated viruses

1965 • 125 citations

The Man Without Qualities

1930 • 123 citations

Identification of genes from pattern formation, tyrosine kinase, and potassium channel families by DNA amplification.

1989 • 123 citations

Molecular cloning and characterization of the chicken gene homologous to the transforming gene of rous sarcoma virus

1981 • 121 citations

Appearance of virus-specific DNA in mammalian cells following transformation by Rous sarcoma virus

1973 • 120 citations

The a subunit in the RNA of transforming avian tumor viruses: I. Occurence in different virus strains. II. Spontaneous loss resulting in nontransforming variants

1972 • 120 citations

Cellular homologue (c-src) of the transforming gene of Rous sarcoma virus: isolation, mapping, and transcriptional analysis of c-src and flanking regions.

1981 • 115 citations

Uninfected avian cells contain RNA related to the transforming gene of avian sarcoma viruses

1978 • 114 citations

Délétions fusionnant ľopéron lactose et un opéron purine chez Escherichia coli

1965 • 109 citations

RNA-directed DNA polymerase of Rous sarcoma virus: Initiation of synthesis with 70 S viral RNA as template

1973 • 106 citations

Les Prix Nobel

2000 • 105 citations

Rous Sarcoma Virus Nucleotide Sequences in Cellular DNA: Measurement by RNA-DNA Hybridization

1972 • 105 citations

Science on trial

1982 • 99 citations

Interaction Between Viral and Genetic Factors in Murine Mammary Cancer

1978 • 97 citations

The vertebrate homolog of the putative transforming gene of avian myelocytomatosis virus: Characteristics of the DNA locus and its RNA transcript

1980 • 97 citations

Characteristics of cellular RNA related to the transforming gene of avian sarcoma viruses

1978 • 88 citations

Transformation of mammalian fibroblasts and macrophages in vitro by a murine retrovirus encoding an avian v-myc oncogene.

1984 • 84 citations

Extent of Transcription by the RNA-dependent DNA Polymerase of Rous Sarcoma Virus

1971 • 84 citations

Chicken macrochromosomes contain an endogenous provirus and microchromosomes contain sequences related to the transforming gene of ASV

1977 • 75 citations

Regulation of Lac Messenger Ribonucleic Acid Synthesis by Cyclic Adenosine 3',5'-Monophosphate and Glucose

1970 • 73 citations

The Next Computer Revolution

1987 • 67 citations

The control of human retrovirus gene expression

1989 • 65 citations

Terminal redundancy and the origin of replication of Rous sarcoma virus RNA.

1977 • 62 citations

Use of DNA-DNA Annealing to Detect New Virus-Specific DNA Sequences in Chicken Embryo Fibroblasts After Infection by Avian Sarcoma Virus

1974 • 61 citations

Viruses, Polymerases, and Cancer

1976 • 58 citations

At least 104 nucleotides are transposed from the 5′ terminus of the avian sarcoma virus genome to the 5′ termini of smaller viral mrnas

1978 • 58 citations

Poliovirus replicative intermediate: Structural basis of infectivity

1969 • 57 citations

Structure and Expression of STK, a src-Related Gene in the Simple Metazoan Hydra attenuata

1989 • 51 citations

Immunosuppressive properties of synthetic peptides derived from CD4 and HLA-DR antigens

1988 • 50 citations

Proto-oncogenes in Drosophila melanogaster

1987 • 49 citations

Characterization of ribonuclease-resistant RNA from poliovirus-infected HeLa cells.

1965 • 48 citations

Massive direct conversion of chick embryo cells by strain MC29 avian leukosis virus

1967 • 45 citations

Transformation-defective mutants of avian sarcoma viruses: The genetic relationship between conditional and nonconditional mutants

1976 • 43 citations

Avian Retroviruses That Cause Carcinoma and Leukemia: Identification of Nucleotide Sequences Associated with Pathogenicity

1980 • 40 citations

Structure and expression of STK, a src-related gene in the simple metazoan Hydra attenuata.

1989 • 39 citations

Cellular src gene product detected in the freshwater sponge Spongilla lacustris.

1984 • 39 citations

On the manner in which the disposition to carcinoma of the mammary gland is inherited in mice

1936 • 36 citations

Double-stranded replicative form of poliovirus RNA: Phenotype of heterozygous molecules

1972 • 23 citations

Control of proliferation in animal cells edited by B. Clarkson and R. Baserga, Pp. 1029. (Cold Spring Harbor Laboratory: New York). $30.00

1974 • 10 citations

Nobel lectures in molecular biology, 1933-1975

1977 • 8 citations

Francis Peyton Rous.

1976 • 6 citations

Transposable elements

1984 • 5 citations