Expression of constitutively activated EGFRvlll in non‐small cell lung cancer

Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin

1985 • 1,523 citations

Levels of TGF-α and EGFR Protein in Head and Neck Squamous Cell Carcinoma and Patient Survival

1998 • 1,083 citations

A mutant epidermal growth factor receptor common in human glioma confers enhanced tumorigenicity.

1994 • 932 citations

Structural alterations of the epidermal growth factor receptor gene in human gliomas.

1992 • 853 citations

Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification.

1987 • 843 citations

Overexpression of the human EGF receptor confers an EGF-dependent transformed phenotype to NIH 3T3 cells

1987 • 657 citations

Frequent expression of a mutant epidermal growth factor receptor in multiple human tumors.

1995 • 633 citations

Amplified and rearranged epidermal growth factor receptor genes in human glioblastomas reveal deletions of sequences encoding portions of the N- and/or C-terminal tails.

1992 • 609 citations

Identical splicing of aberrant epidermal growth factor receptor transcripts from amplified rearranged genes in human glioblastomas.

1990 • 593 citations

The Enhanced Tumorigenic Activity of a Mutant Epidermal Growth Factor Receptor Common in Human Cancers Is Mediated by Threshold Levels of Constitutive Tyrosine Phosphorylation and Unattenuated Signaling

1997 • 591 citations

Monoclonal antibodies against EGFRvIII are tumor specific and react with breast and lung carcinomas and malignant gliomas.

1995 • 465 citations

Epidermal-Growth-Factor-Dependent Transformation by a Human EGF Receptor Proto-Oncogene

1987 • 448 citations

A common mutant epidermal growth factor receptor confers enhanced tumorigenicity on human glioblastoma cells by increasing proliferation and reducing apoptosis.

1996 • 407 citations

Constitutive Activation of Phosphatidylinositol 3-Kinase by a Naturally Occurring Mutant Epidermal Growth Factor Receptor

1998 • 304 citations

Functional characterization of an EGF receptor with a truncated extracellular domain expressed in glioblastomas with EGFR gene amplification.

1994 • 255 citations

Expression of mutated epidermal growth factor receptor by non-small cell lung carcinomas.

1993 • 246 citations

The type III epidermal growth factor receptor mutation

2001 • 241 citations

Amplification of the structurally and functionally altered epidermal growth factor receptor gene (c-erbB) in human brain tumors.

1988 • 218 citations

Growth suppression of intracranial xenografted glioblastomas overexpressing mutant epidermal growth factor receptors by systemic administration of monoclonal antibody (mAb) 806, a novel monoclonal antibody directed to the receptor.

2001 • 204 citations

Transformational and altered signal transduction by a naturally occurring mutant EGF receptor.

1996 • 195 citations

Unarmed, tumor-specific monoclonal antibody effectively treats brain tumors

2000 • 190 citations

Receptor dimerization is not a factor in the signalling activity of a transforming variant epidermal growth factor receptor (EGFRvIII)

1997 • 186 citations

Monoclonal antibody 806 inhibits the growth of tumor xenografts expressing either the de2-7 or amplified epidermal growth factor receptor (EGFR) but not wild-type EGFR.

2001 • 171 citations

Tyrosine kinase inhibitors—ZD1839 (Iressa)

2001 • 171 citations

Constitutive Activation of c-Jun N-terminal Kinase by a Mutant Epidermal Growth Factor Receptor

1998 • 163 citations

Evidence for the differential expression of a variant EGF receptor protein in human prostate cancer

2000 • 158 citations

Epidermal growth factor receptor vIII enhances tumorigenicity in human breast cancer.

2000 • 147 citations

Changes in Bronchial Epithelium in Relation to Sex, Age, Residence, Smoking and Pneumonia

1962 • 134 citations

Amplification and overexpression of the cyclin D1 and epidermal growth factor receptor genes in non-small-cell lung cancer

1999 • 121 citations

The EGF receptor: structure, regulation and potential role in malignancy.

1985 • 115 citations

Epidermal growth factor receptor and other oncogenes as prognostic markers.

1992 • 98 citations

Biological basis of anemia

2001 • 96 citations

A naturally occurring mutant human epidermal growth factor receptor as a target for peptide vaccine immunotherapy of tumors.

1997 • 89 citations

Epidermal Growth Factor Receptor Expression in Human Lung Carcinomas Defined by a Monoclonal Antibody<xref ref-type="fn" rid="FN2">2</xref>

1987 • 85 citations

Amplification of the Structurally and Functionally Altered Epidermal Growth Factor Receptor Gene (c-erbB) in Human Brain Tumors

1988 • 53 citations

Genetic changes in lung cancer

1993 • 26 citations

Current perspectives in the treatment of non-small cell lung cancer

1993 • 7 citations

Introduction

2001 • 2 citations