The origins of protein phosphorylation

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1995 • 5,143 citations

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

1991 • 4,043 citations

A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).

1994 • 3,249 citations

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα

1997 • 2,747 citations

Transforming gene product of Rous sarcoma virus phosphorylates tyrosine

1980 • 2,387 citations

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

1995 • 2,106 citations

Protein kinases — the major drug targets of the twenty-first century?

2002 • 2,101 citations

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

1995 • 2,024 citations

Cyanobacterial microcystin‐LR is a potent and specific inhibitor of protein phosphatases 1 and 2A from both mammals and higher plants

1990 • 1,627 citations

An Adenosine 3′,5′-Monophosphate-dependant Protein Kinase from Rabbit Skeletal Muscle

1968 • 1,423 citations

Activation of calcium and phospholipid-dependent protein kinase by diacylglycerol, its possible relation to phosphatidylinositol turnover.

1980 • 1,317 citations

Signalling through the lipid products of phosphoinositide-3-OH kinase

1997 • 1,314 citations

Identification of phosphotyrosine as a product of epidermal growth factor-activated protein kinase in A-431 cell membranes.

1980 • 1,184 citations

Insulin Stimulates the Phosphorylation of the 95,000-Dalton Subunit of Its Own Receptor

1982 • 1,138 citations

Protein kinase activity associated with the avian sarcoma virus src gene product.

1978 • 1,137 citations

The role of protein phosphorylation in neural and hormonal control of cellular activity

1982 • 1,116 citations

Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase

1990 • 1,087 citations

Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate

1988 • 1,027 citations

CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASES, IV. WIDESPREAD OCCURRENCE OF ADENOSINE 3′,5′-MONOPHOSPHATE-DEPENDENT PROTEIN KINASE IN VARIOUS TISSUES AND PHYLA OF THE ANIMAL KINGDOM

1969 • 775 citations

α-KETO ACID DEHYDROGENASE COMPLEXES, X. REGULATION OF THE ACTIVITY OF THE PYRUVATE DEHYDROGENASE COMPLEX FROM BEEF KIDNEY MITOCHONDRIA BY PHOSPHORYLATION AND DEPHOSPHORYLATION

1969 • 669 citations

AKAPs: from structure to function

1999 • 619 citations

Identification of the Ca²⁺‐dependent modulator protein as the fourth subunit of rabbit skeletal muscle phosphorylase kinase

1978 • 619 citations

Binding of SH2 Domains of Phospholipase Cγ1, GAP, and Src to Activated Growth Factor Receptors

1990 • 608 citations

Rapid stimulation by insulin of a serine/threonine kinase in 3T3-L1 adipocytes that phosphorylates microtubule-associated protein 2 in vitro.

1987 • 604 citations

Dissection of the protein kinase cascade by which nerve growth factor activates MAP kinases

1991 • 579 citations

Purification of the major protein-tyrosine-phosphatases of human placenta.

1988 • 564 citations

THE ENZYMATIC PHOSPHORYLATION OF PROTEINS

1954 • 537 citations

Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase

1995 • 520 citations

Multiple components in an epidermal growth factor-stimulated protein kinase cascade

1991 • 502 citations

Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinase.

1991 • 499 citations

CONVERSION OF PHOSPHORYLASE b TO PHOSPHORYLASE a IN MUSCLE EXTRACTS

1955 • 496 citations

Activation of extracellular signal-regulated kinase, ERK2, by p21ras oncoprotein.

1992 • 490 citations

Modulator protein as a component of the myosin light chain kinase from chicken gizzard

1978 • 488 citations

A Noncatalytic Domain Conserved among Cytoplasmic Protein-Tyrosine Kinases Modifies the Kinase Function and Transforming Activity of Fujinami Sarcoma Virus P130^gag-fps

1986 • 478 citations

Discovery of A Ca²⁺‐and calmodulin‐dependent protein phosphatase

1982 • 476 citations

The Protein Phosphatases Involved in Cellular Regulation. 1. Classification and Substrate Specificities

1983 • 471 citations

The phosphorylase b to a converting enzyme of rabbit skeletal muscle

1956 • 463 citations

Phosphorylation of a 22,000-dalton component of the cardiac sarcoplasmic reticulum by adenosine 3':5'-monophosphate-dependent protein kinase.

1975 • 431 citations

Demonstration that the leukocyte common antigen (CD45) is a protein tyrosine phosphatase

1988 • 425 citations

The Regulation of Skeletal Muscle Phosphorylase Kinase by Ca2+

1971 • 416 citations

Inactivation of Glycogen Synthetase and Activation of Phosphorylase Kinase by Muscle Adenosine 3',5'-Monophosphate-dependent Protein Kinases

1970 • 410 citations

Stimulation of brain membrane protein phosphorylation by calcium and an endogenous heat-stable protein

1978 • 332 citations

A noncatalytic domain conserved among cytoplasmic protein-tyrosine kinases modifies the kinase function and transforming activity of Fujinami sarcoma virus P130gag-fps.

1986 • 317 citations

An inositol tetrakisphosphate-containing phospholipid in activated neutrophils

1988 • 292 citations

The protein phosphatases involved in cellular regulation

1985 • 261 citations

CRYSTALLINE MUSCLE PHOSPHORYLASE

1943 • 244 citations

Control of Phosphorylase Activity in a Muscle Glycogen Particle

1970 • 244 citations

Activation of Adipose Tissue Lipase by Skeletal Muscle Cyclic Adenosine 3',5'-Monophosphate-stimulated Protein Kinase

1970 • 216 citations

The minimum substrate of cyclic AMP-stimulated protein kinase, as studied by synthetic peptides representing the phosphorylatable site of pyruvate kinase (type L) of rat liver

1976 • 214 citations

PHOSPHORYLATION OF LIVER HISTONE FOLLOWING THE ADMINISTRATION OF GLUCAGON AND INSULIN

1969 • 208 citations

Synthetic hexapeptide substrates and inhibitors of 3':5'-cyclic AMP-dependent protein kinase.

1976 • 206 citations

Structure of the Site Phosphorylated in the Phosphorylase b to a Reaction

1959 • 194 citations

Hyoscyamine 6β-hydroxylase, an enzyme involved in tropane alkaloid biosynthesis, is localized at the pericycle of the root

1991 • 193 citations

Complete amino acid sequence of the catalytic subunit of bovine cardiac muscle cyclic AMP-dependent protein kinase.

1981 • 188 citations

High affinity binding protein for the regulatory subunit of cAMP-dependent protein kinase II-B

1989 • 184 citations

Histidine and aspartate phosphorylation: two-component systems and the limits of homology

1994 • 181 citations

Phosphorylation of purified rat liver pyruvate kinase by cyclic 3′,5′-AMP-stimulated protein kinase

1974 • 172 citations

Inactivation and Activation of Liver Phosphorylase

1955 • 158 citations

Correlation between contraction and phosphorylation of the inhibitory subunit of troponin in perfused rat heart

1975 • 151 citations

Cell cycle control genes in yeast

1985 • 146 citations

A multifunctional calmodulin‐dependent protein kinase

1983 • 134 citations

The growth of research on protein phosphorylation

1994 • 100 citations

Synthetic substrate for cyclic AMP-dependent protein kinase

1975 • 96 citations

Characterization of protein kinases forming acid-labile histone phosphates in Walker-256 carcinosarcoma cell nuclei

1974 • 89 citations

Cytokine signal transduction and the JAK family of protein tyrosine kinases

1994 • 89 citations

The molecular mechanism by which adrenalin inhibits glycogen synthesis

1991 • 80 citations

Presence in liver of a 3′:5′-cyclic AMP stimulated kinase for the I form of UDPG-glycogen glucosyltransferase

1969 • 47 citations

Characterization of an arginine‐specific protein kinase tightly bound to rat liver DNA

1987 • 30 citations

The regulation of protein function by multisite phosphorylation

1976 • 30 citations

Sugar and diabetes

1976 • 16 citations

Phosphoenolpyruvate‐dependent protein kinase activity in rat skeletal muscle

1983 • 12 citations