Eukaryotic signal transduction via histidine-aspartate phosphorelay

The Genome Sequence of Drosophila melanogaster

2000 • 5,882 citations

Genome Sequence of the Nematode C. elegans : A Platform for Investigating Biology

1998 • 3,683 citations

Genome sequence of the nematode C-elegans: A platform for investigating biology

1998 • 3,265 citations

Arabidopsis Ethylene-Response Gene ETR1 : Similarity of Product to Two-Component Regulators

1993 • 1,478 citations

A two-component system that regulates an osmosensing MAP kinase cascade in yeast

1994 • 1,091 citations

Ethylene Responses Are Negatively Regulated by a Receptor Gene Family in Arabidopsis thaliana

1998 • 1,036 citations

Yeast HOG1 MAP Kinase Cascade Is Regulated by a Multistep Phosphorelay Mechanism in the SLN1–YPD1–SSK1 “Two-Component” Osmosensor

1996 • 876 citations

Initiation of sporulation in B. subtilis is controlled by a multicomponent phosphorelay

1991 • 870 citations

Signal transduction schemes of bacteria

1993 • 781 citations

Two-component and phosphorelay signal transduction

2000 • 765 citations

CKI1, a Histidine Kinase Homolog Implicated in Cytokinin Signal Transduction

1996 • 616 citations

Osmotic Activation of the HOG MAPK Pathway via Ste11p MAPKKK: Scaffold Role of Pbs2p MAPKK

1997 • 569 citations

A Transmembrane Hybrid-Type Histidine Kinase in Arabidopsis Functions as an Osmosensor

1999 • 543 citations

A Cyanobacterial Phytochrome Two-Component Light Sensory System

1997 • 534 citations

SIGNAL TRANSDUCTION PATHWAYS INVOLVING PROTEIN PHOSPHORYLATION IN PROKARYOTES

1991 • 512 citations

Association of the Arabidopsis CTR1 Raf-like kinase with the ETR1 and ERS ethylene receptors

1998 • 510 citations

Structure of CheA, a Signal-Transducing Histidine Kinase

1999 • 471 citations

A Yeast Protein Similar to Bacterial Two-Component Regulators

1993 • 431 citations

Signal Transduction via the Multi-Step Phosphorelay: Not Necessarily a Road Less Traveled

1996 • 427 citations

Eukaryotic phytochromes: Light-regulated serine/threonine protein kinases with histidine kinase ancestry

1998 • 412 citations

The Histidine Protein Kinase Superfamily

1999 • 376 citations

Role of the Mitogen-Activated Protein Kinase Hog1p in Morphogenesis and Virulence of Candida albicans

1999 • 333 citations

The VanS-VanR two-component regulatory system controls synthesis of depsipeptide peptidoglycan precursors in Enterococcus faecium BM4147

1992 • 327 citations

A genomic analysis of two‐component signal transduction in Streptococcus pneumoniae

2000 • 321 citations

Histidine kinase activity of the ETR1 ethylene receptor from Arabidopsis

1998 • 317 citations

A small catalytic RNA motif with Diels-Alderase activity

1999 • 314 citations

Regulatory networks controlling Candida albicans morphogenesis

1999 • 299 citations

Activation of the yeast SSK2 MAP kinase kinase kinase by the SSK1 two-component response regulator

1998 • 289 citations

The Skn7 response regulator controls gene expression in the oxidative stress response of the budding yeast Saccharomyces cerevisiae

1997 • 284 citations

MOLECULAR GENETICS OF SIGNAL TRANSDUCTION IN DICTYOSTELIUM

1996 • 261 citations

NMR structure of the histidine kinase domain of the E. coli osmosensor EnvZ

1998 • 256 citations

Sequence and Function of LuxU: a Two-Component Phosphorelay Protein That Regulates Quorum Sensing in Vibrio harveyi

1999 • 245 citations

Hyphal development in Neurospora crassa: involvement of a two-component histidine kinase.

1996 • 224 citations

Integration of multiple domains in a two-component sensor protein: the Bordetella pertussis BvgAS phosphorelay.

1996 • 222 citations

Analysis of RhoA-binding Proteins Reveals an Interaction Domain Conserved in Heterotrimeric G Protein β Subunits and the Yeast Response Regulator Protein Skn7

1998 • 208 citations

Two-component systems in plant signal transduction

2000 • 207 citations

A two‐component signal‐transducing system is involved in competence and penicillin susceptibility in laboratory mutants of Streptococcus pneumoniae

1994 • 204 citations

Domain organization and molecular characterization of 13 two-component systems identified by genome sequencing of Streptococcus pneumoniae

1999 • 191 citations

The yeast histidine protein kinase, Sln1p, mediates phosphotransfer to two response regulators, Ssk1p and Skn7p

1998 • 183 citations

The Mcs4 response regulator coordinately controls the stress-activated Wak1-Wis1-Sty1 MAP kinase pathway and fission yeast cell cycle.

1997 • 181 citations

Branched-chain alpha-ketoacid dehydrogenase kinase. Molecular cloning, expression, and sequence similarity with histidine protein kinases.

1992 • 176 citations

Developmental signal transduction pathways uncovered by genetic suppressors

1996 • 173 citations

Multiple Mechanisms of Action for Inhibitors of Histidine Protein Kinases from Bacterial Two-Component Systems

1999 • 169 citations

Integration of Signaling Networks that Regulate Dictyostelium Differentiation

1999 • 167 citations

Multistep Phosphorelay Proteins Transmit Oxidative Stress Signals to the Fission Yeast Stress-activated Protein Kinase

2000 • 165 citations

Roles of Three Histidine Kinase Genes in Hyphal Development and Virulence of the Pathogenic Fungus Candida albicans

1999 • 164 citations

A cAMP-phosphodiesterase controls PKA-dependent differentiation

1998 • 155 citations

Yeast Skn7p functions in a eukaryotic two-component regulatory pathway.

1994 • 155 citations

β‐Lactam resistance in Streptococcus pneumoniae: penicillin‐binding proteins and non‐penicillin‐binding proteins

1999 • 152 citations

Primary structure of pyruvate dehydrogenase kinase establishes a new family of eukaryotic protein kinases.

1993 • 152 citations

An intersection of the cAMP/PKA and two-component signal transduction systems in Dictyostelium

1998 • 150 citations

The hybrid histidine kinase DokA is part of the osmotic response system of Dictyostelium.

1996 • 141 citations

Defective Hyphal Development and Avirulence Caused by a Deletion of the SSK1 Response Regulator Gene in Candida albicans

2000 • 140 citations

COS1 , a two-component histidine kinase that is involved in hyphal development in the opportunistic pathogen Candida albicans

1998 • 129 citations

Dimerization Is Required for the Activity of the Protein Histidine Kinase CheA That Mediates Signal Transduction in Bacterial Chemotaxis

1996 • 129 citations

Mcs4 mitotic catastrophe suppressor regulates the fission yeast cell cycle through the Wik1-Wis1-Spc1 kinase cascade.

1997 • 129 citations

A two-component histidine kinase gene that functions in Dictyostelium development.

1996 • 114 citations

Formation of a Novel Four-Helix Bundle and Molecular Recognition Sites by Dimerization of a Response Regulator Phosphotransferase

1998 • 108 citations

Phosphorelay signal transduction: the emerging family of plant response regulators

1999 • 102 citations

Signal Transduction Pathways Leading to Spore Differentiation inDictyostelium discoideum

1998 • 98 citations

SDF-2 Induction of Terminal Differentiation in Dictyostelium discoideum Is Mediated by the Membrane-Spanning Sensor Kinase DhkA

1999 • 96 citations

An adenylyl cyclase that functions during late development of Dictyostelium

1999 • 94 citations

The two-component hybrid kinase regulator CaNIKl of Candida albicans

1998 • 92 citations

Conservation of structure and function among histidine-containing phosphotransfer (HPt) domains as revealed by the crystal structure of YPD1 1 1Edited by I. A. Wilson

1999 • 88 citations

The Histidine KinasedhkCRegulates the Choice between Migrating Slugs and Terminal Differentiation inDictyostelium discoideum

1998 • 87 citations

Protein aspartate phosphatases control the output of two-component signal transduction systems

1996 • 86 citations

Intracellular Glycerol Levels Modulate the Activity of Sln1p, aSaccharomyces cerevisiae Two-component Regulator

1999 • 84 citations

The RdeA-RegA System, a Eukaryotic Phospho-relay Controlling cAMP Breakdown

1999 • 82 citations

NMR studies of the phosphotransfer domain of the histidine kinase CheA from Escherichia coli: assignments, secondary structure, general fold, and backbone dynamics

1995 • 79 citations

Isolation and characterization of multiple adenylate cyclase genes from the cyanobacterium Anabaena sp. strain PCC 7120

1997 • 79 citations

Flocculation of hyphae is associated with a deletion in the putative CaHK1 two-component histidine kinase gene from Candida albicans

1999 • 79 citations

Histidine kinases and two-component signal transduction systems

1999 • 77 citations

The ethylene signal transduction pathway in Arabidopsis: an emerging paradigm?

1996 • 77 citations

Purification of a protein histidine kinase from the yeast Saccharomyces cerevisiae. The first member of this class of protein kinases

1991 • 74 citations

Evidence that the RdeA protein is a component of a multistep phosphorelay modulating rate of development in Dictyostelium

1998 • 73 citations

Candida pathogenesis: Unravelling the threads of infection

1997 • 71 citations

A Fission Yeast Gene (prrl+) That Encodes a Response Regulator Implicated in Oxidative Stress Response

1999 • 71 citations

Taking the plunge: terminal differentiation in Dictyostelium

1999 • 65 citations

A Novel Adenylyl Cyclase Detected in Rapidly Developing Mutants of Dictyostelium

1998 • 64 citations

Association of the Cell Cycle Transcription Factor Mbp1 with the Skn7 Response Regulator in Budding Yeast

1999 • 64 citations

Differential Stabilities of Phosphorylated Response Regulator Domains Reflect Functional Roles of the Yeast Osmoregulatory SLN1 and SSK1 Proteins

1999 • 58 citations

In VivoCharacterization of the Unorthodox BvgS Two-component Sensor Protein ofBordetella pertussis

1995 • 57 citations

The Hybrid Histidine KinasedhkBRegulates Spore Germination inDictyostelium discoideum

1998 • 56 citations

Phytochrome: If It Looks and Smells Like a Histidine Kinase, Is It a Histidine Kinase?

1997 • 54 citations

Insights into eukaryotic multistep phosphorelay signal transduction revealed by the crystal structure of Ypd1p from Saccharomyces cerevisiae

1999 • 52 citations

Production and activity of spore differentiation factors (SDFs) in Dictyostelium

1998 • 50 citations

Activation of a Cyanobacterial Adenylate Cyclase, CyaC, by Autophosphorylation and a Subsequent Phosphotransfer Reaction

1999 • 44 citations

Molecular Analysis of Two Pyruvate Dehydrogenase Kinases from Maize

1998 • 43 citations

Detection of a mammalian histone H4 kinase that has yeast histidine kinase-like enzymic activity

2000 • 42 citations

The Spirulina platensis Adenylate Cyclase Gene, cyaC, Encodes a Novel Signal Transduction Protein

1997 • 42 citations

High cAMP in spores of Dictyostelium discoideum: association with spore dormancy and inhibition of germination

1999 • 40 citations

Signal transduction: Gyrating protein kinases

1999 • 35 citations

The Genome of the Nematode Caenorhabditis elegans

1993 • 32 citations

Antifungal Properties and Target Evaluation of Three Putative Bacterial Histidine Kinase Inhibitors

1999 • 32 citations

Mcs4, a Two-Component System Response Regulator Homologue, Regulates the Schizosaccharomyces pombe Cell Cycle Control

1997 • 31 citations

Nonplastid Eukaryotic Response Regulators Have a Monophyletic Origin and Evolved from Their Bacterial Precursors in Parallel with Their Cognate Sensor Kinases

1997 • 25 citations